Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Searching for genetic determinants of malignancy in follicular thyroid lesions employing genomic screening

2015/19/N/NZ5/02257

Keywords:

follicular thyroid cancer follicular thyroid adenoma next-generation sequencing molecular inversion probe genome-based high throughput sreening

Descriptors:

  • NZ5_5: Diagnostics in human diseases
  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Martyna Borowczyk 

Number of co-investigators in the project: 3

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2016-08-16

Project end date (Y-m-d): 2019-08-15

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. High incidence of FLT3 mutations in follicular thyroid cancer – potential therapeutic target in patients with advanced disease stage
    Authors:
    Martyna Borowczyk*, Ewelina Szczepanek-Parulska*, Szymon Dębicki, Bartłomiej Budny, Małgorzata Janicka-Jedyńska, Lidia Gil, Frederik A. Verburg, Dorota Filipowicz, Elżbieta Wrotkowska, Blanka Majchrzycka, Andrzej Marszałek, Katarzyna Ziemnicka, Marek Ruchała
    Academic press:
    Therapeutic Advances in Medical Oncology (rok: 2020, tom: 12, strony: 45306), Wydawca: SAGE Journals
    Status:
    Published
    DOI:
    10.1177/1758835920907534 - link to the publication
  2. The genetic heterogeneity of indeterminate thyroid nodules assessed preoperatively with next generation sequencing reflects the diversity of the final histopathological diagnoses
    Authors:
    Martyna Borowczyk, Ewelina Szczepanek-Parulska, Szymon Dębicki, Bartłomiej Budny, Frederik A. Verburg, Dorota Filipowicz, Elżbieta Wrotkowska, Małgorzata Janicka-Jedyńska, Barbara Więckowska, Lidia Gil, Katarzyna Ziemnicka, Marek Ruchała
    Academic press:
    Polish Archives of Internal Medicine (rok: 2019, tom: -, strony: -), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.14979 - link to the publication
  3. Differences in mutational profile between follicular thyroid carcinoma and follicular thyroid adenoma identified using next generation sequencing
    Authors:
    Martyna Borowczyk, Ewelina Szczepanek-Parulska, Szymon Dębicki, Bartłomiej Budny, Frederik A. Verburg, Dorota Filipowicz, Barbara Więckowska, Małgorzata Janicka-Jedyńska, Lidia Gil, Katarzyna Ziemnicka, Marek Ruchała
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: pii: E3126), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20133126 - link to the publication
  4. Evaluation of 167 Gene Expression Classifier (GEC) and ThyroSeq v2 Diagnostic Accuracy in the Preoperative Assessment of Indeterminate Thyroid Nodules: Bivariate/HROC Meta-analysis
    Authors:
    Martyna Borowczyk, Ewelina Szczepanek-Parulska, Michał Olejarz, Barbara Więckowska, Frederik A. Verburg, Szymon Dębicki, Bartłomiej Budny, Małgorzata Janicka-Jedyńska, Katarzyna Ziemnicka, Marek Ruchała
    Academic press:
    Endocrine Pathology (rok: 2019, tom: 1,25069444444444, strony: 45519), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12022-018-9560-5 - link to the publication
  1. New markers of follicular thyroid cancer found with wide-panel next-generation sequencing
    Authors:
    Martyna Borowczyk, Ewelina Szczepanek-Parulska, Szymon Dębicki, Bartłomiej Budny, Małgorzata Janicka-Jedyńska, Elżbieta Wrotkowska, Blanka Majchrzycka, Katarzyna Ziemnicka, Marek Ruchała
    Conference:
    20th European Congress of Endocrinology (rok: 2018, ), Wydawca: bioscientifica
    Data:
    konferencja 19-22.05.2018
    Status:
    Published
  2. TP53 and FLT3 may become candidate markers for detecting malignancy in follicular lesions
    Authors:
    Martyna Borowczyk, Ewelina Szczepanek-Parulska, Szymon Dębicki, Bartłomiej Budny, Frederik A Verburg, Małgorzata Janicka-Jedyńska, Barbara Więckowska, Lidia Gil, Dorota Filipowicz, Katarzyna Ziemnicka, Marek Ruchała
    Conference:
    21st European Congress of Endocrinology (rok: 2019, ), Wydawca: bioscientifica
    Data:
    konferencja 18-21.05.2019
    Status:
    Published

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