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Searching for genetic determinants of malignancy in follicular thyroid lesions employing genomic screening

2015/19/N/NZ5/02257

Keywords

Descriptors

  • NZ5_5: Diagnostyka chorób człowieka
  • NZ5_1: Etiologia chorób człowieka
  • NZ5_3: Patogeneza chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Martyna Joanna Borowczyk

Number of co-investigators in the project: 3

Call

PRELUDIUM 10 – announced on 2015-09-15

Amount awarded
150 000 PLN
Project start date
2016-08-16
Project end date
2019-08-15
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (4)

  1. Differences in mutational profile between follicular thyroid carcinoma and follicular thyroid adenoma identified using next generation sequencing

    Authors:
    Martyna Borowczyk, Ewelina Szczepanek-Parulska, Szymon Dębicki, Bartłomiej Budny, Frederik A. Verburg, Dorota Filipowicz, Barbara Więckowska, Małgorzata Janicka-Jedyńska, Lidia Gil, Katarzyna Ziemnicka, Marek Ruchała
    Academic press:
    International Journal of Molecular Sciences (year: 2019, volume: 20, pages: pii: E3126), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20133126 – link to the publication

  2. The genetic heterogeneity of indeterminate thyroid nodules assessed preoperatively with next generation sequencing reflects the diversity of the final histopathological diagnoses

    Authors:
    Martyna Borowczyk, Ewelina Szczepanek-Parulska, Szymon Dębicki, Bartłomiej Budny, Frederik A. Verburg, Dorota Filipowicz, Elżbieta Wrotkowska, Małgorzata Janicka-Jedyńska, Barbara Więckowska, Lidia Gil, Katarzyna Ziemnicka, Marek Ruchała
    Academic press:
    Polish Archives of Internal Medicine (year: 2019, volume: -, pages: -), Publisher: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.14979 – link to the publication

  3. High incidence of FLT3 mutations in follicular thyroid cancer – potential therapeutic target in patients with advanced disease stage

    Authors:
    Martyna Borowczyk*, Ewelina Szczepanek-Parulska*, Szymon Dębicki, Bartłomiej Budny, Małgorzata Janicka-Jedyńska, Lidia Gil, Frederik A. Verburg, Dorota Filipowicz, Elżbieta Wrotkowska, Blanka Majchrzycka, Andrzej Marszałek, Katarzyna Ziemnicka, Marek Ruchała
    Academic press:
    Therapeutic Advances in Medical Oncology (year: 2020, volume: 12, pages: 46037), Publisher: SAGE Journals
    Status:
    Published
    DOI:
    10.1177/1758835920907534 – link to the publication

  4. Evaluation of 167 Gene Expression Classifier (GEC) and ThyroSeq v2 Diagnostic Accuracy in the Preoperative Assessment of Indeterminate Thyroid Nodules: Bivariate/HROC Meta-analysis

    Authors:
    Martyna Borowczyk, Ewelina Szczepanek-Parulska, Michał Olejarz, Barbara Więckowska, Frederik A. Verburg, Szymon Dębicki, Bartłomiej Budny, Małgorzata Janicka-Jedyńska, Katarzyna Ziemnicka, Marek Ruchała
    Academic press:
    Endocrine Pathology (year: 2019, volume: 1,25069444444444, pages: 46249), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12022-018-9560-5 – link to the publication

Articles in post-conference publications (2)

  1. New markers of follicular thyroid cancer found with wide-panel next-generation sequencing

    Authors:
    Martyna Borowczyk, Ewelina Szczepanek-Parulska, Szymon Dębicki, Bartłomiej Budny, Małgorzata Janicka-Jedyńska, Elżbieta Wrotkowska, Blanka Majchrzycka, Katarzyna Ziemnicka, Marek Ruchała
    Conference:
    20th European Congress of Endocrinology (year: 2018, pages: -), Publisher: bioscientifica
    Date:
    conference 19-22.05.2018
    Status:
    Published

  2. TP53 and FLT3 may become candidate markers for detecting malignancy in follicular lesions

    Authors:
    Martyna Borowczyk, Ewelina Szczepanek-Parulska, Szymon Dębicki, Bartłomiej Budny, Frederik A Verburg, Małgorzata Janicka-Jedyńska, Barbara Więckowska, Lidia Gil, Dorota Filipowicz, Katarzyna Ziemnicka, Marek Ruchała
    Conference:
    21st European Congress of Endocrinology (year: 2019, pages: -), Publisher: bioscientifica
    Date:
    conference 18-21.05.2019
    Status:
    Published

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