Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The evaluation of cathelicidin preventive and therapeutic properties against pulmonary fibrosis. In vivo and molecular studies in the mice model of hypersensitivity pneumonitis (HP)

2015/19/D/NZ7/02952

Keywords:

pulmonary fibrosis hypersensitivity pneumonitis cathelicidin LL-37 Pantoea agglomerans

Descriptors:

  • NZ7_2: Environment and health risks
  • NZ7_12: Prevention of human diseases
  • NZ7_15: Toxicology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Wsi im. Witolda Chodźki

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Lemieszek 

Number of co-investigators in the project: 7

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 939 800 PLN

Project start date (Y-m-d): 2016-07-11

Project end date (Y-m-d): 2020-04-10

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Homogenizator FastPrep-24 5G (45 000 PLN)
  2. Wieża Inhalacyjna z Pletyzmografem (368 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (1)
  1. Beneficial impact of cathelicidin on hypersensitivity pneumonitis treatment – in vivo studies
    Authors:
    Marta Kinga Lemieszek, Katarzyna Sawa-Wejksza, Marcin Golec, Jacek Dutkiewicz, Jacek Zwoliński, Janusz Milanowski
    Academic press:
    PLOS One (rok: 2021, tom: 16, strony: e0251237), Wydawca: PUBLIC LIBRARY SCIENCE, 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
    Status:
    Published
    DOI:
    10.1371/journal.pone.0251237 - link to the publication
  2. Pantoea agglomerans chronic exposure induces epithelial-mesenchymal transition in human lung epithelial cells and mice lungs
    Authors:
    Marta Kinga Lemieszek, Wojciech Rzeski, Marcin Golec, Barbara Mackiewicz, Jacek Zwoliński, Jacek Dutkiewicz, Janusz Milanowski
    Academic press:
    Ecotoxicology and Environmental Safety (rok: 2020, tom: 194, strony: 110416), Wydawca: ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
    Status:
    Published
    DOI:
    10.1016/j.ecoenv.2020.110416 - link to the publication
  3. Cathelicidin treatment silences epithelial-mesenchymal transition involved in pulmonary fibrosis in a murine model of hypersensitivity pneumonitis
    Authors:
    Marta Kinga Lemieszek, Marcin Golec, Jacek Zwoliński, Jacek Dutkiewicz, Janusz Milanowski
    Academic press:
    Pharmacological Reports , Wydawca: SPRINGER HEIDELBERG, TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Cathelicidin treatment reduces negative changes in the expression of genes involved in pulmonary fibrosis in mice model of hypersensitivity pneumonitis
    Authors:
    Marta Kinga Lemieszek, Marcin Golec, Jacek Dutkiewicz, Jacek Zwoliński, Janusz Milanowski
    Conference:
    The Annual Congress of the European Academy of Allergy and Clinical Immunology (rok: 2019, ), Wydawca: WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
    Data:
    konferencja 01-05 czerwiec
    Status:
    Published

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