Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Osteoprotegerin - ally or enemy of blood vessels calcification in the experimental model of chronic kidney disease in rat?

2015/19/N/NZ5/00265

Keywords:

osteoprotegerin RANKL TRAIL vascular calcification chronic kidney disease

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Beata Sieklucka 

Number of co-investigators in the project: 3

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2016-08-16

Project end date (Y-m-d): 2020-08-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (3)
  1. RANKL/OPG system regulation by endogenous PTH and PTH1R/ATF4 axis in bone: Implications for bone accrual and strength in growing rats with mild uremia
    Authors:
    Znorko B, Pawlak D, Oksztulska-Kolanek E, Domaniewski T, Pryczynicz A, Roszczenko A, Rogalska J, Lipowicz P, Doroszko M, Brzoska MM, Pawlak K.
    Academic press:
    Cytokine (rok: 2018, tom: 106, strony: 19-28), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cyto.2018.03.002 - link to the publication
  1. THE ROLE OF OPG/RANKL/TRAIL AXIS IN VASCULAR CALCIFICATION IN AN ADENINE-INDUCED RAT MODEL OF CHRONIC KIDNEY DISEASE
    Authors:
    B. SIEKLUCKA, T. Domaniewski, M. Galazyn-Sidorczuk, A. Pryczynicz, K. Guzinska-Ustymowicz, K. Pawlak
    Conference:
    ISN WCN 2019 (rok: 2019, ), Wydawca: Kidney International Reports, Volume 4, Issue 7, S275 - S276
    Data:
    konferencja 43567
    Status:
    Published
  2. WZROST STĘŻENIA ENDOGENNEGO PTH ORAZ AKTYWACJA ANABOLICZNEJ ŚCIEŻKI SYGNAŁOWEJ PTH1R/ATF4 KORZYSTNIE WPŁYWA NA WŁAŚCIWOŚCI GEOMETRYCZNE KOŚCI UDOWEJ W MODELU PRZEWLEKŁEJ CHOROBY NEREK U MŁODYCH SZCZURÓW
    Authors:
    Beata Sieklucka, Tomasz Domaniewski, Ewa Oksztulska-Kolanek, Alicja Roszczenko, Paweł Lipowicz, Magdalena Jakuc, Dariusz Pawlak, Krystyna Pawlak
    Conference:
    SZKOŁA CHEMII MEDYCZNEJ (rok: 2019, ), Wydawca: UNIWERSYTET MEDYCZNY IM. PIASTÓW ŚLĄSKICH WE WROCŁAWIU
    Data:
    konferencja 43733
    Status:
    Published
  3. Correlations between OPG/RANKL/RANK axis, vitamin D status, PTH and vascular calcification in an adenine-induced model of chronic kidney disease.
    Authors:
    Sieklucka Beata, Domaniewski Tomasz, Ziemińska Marta, Gałażyn-Sidorczuk Małgorzata, Pawlak Anna, Pawlak Dariusz, Pawlak Dariusz.
    Conference:
    57th ERA-EDTA Congress (rok: 2020, ), Wydawca: Nephrology Dialysis Transplantation
    Data:
    konferencja 6-9.06.2020
    Status:
    Published