Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of microRNAs in regulation iron metabolism in Friedreich's ataxia

2015/19/B/NZ1/02804

Keywords:

neurological diseases Friedreich's ataxia GAA repeats iron metabolism miRNA

Descriptors:

  • NZ1_1: Molecular biology
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ3_5: Molecular neurobiology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marek Napierała 

Number of co-investigators in the project: 4

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 094 800 PLN

Project start date (Y-m-d): 2016-07-14

Project end date (Y-m-d): 2020-04-13

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Autoklaw.
  2. Termocykler Real-Time PCR.
  3. Analizator RNA, DNA i bialek (100 000 PLN)
  4. Komputer z oprogramowaniem (2 szt.) (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming
    Authors:
    Urszula Polak, Yanjie Li, Jill Sergesketter Butler, Marek Napierala
    Academic press:
    Stem Cells And Development (rok: 2016, tom: 25(23), strony: 1788–1800), Wydawca: MARY ANN LIEBERT, INC, 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
    Status:
    Published
    DOI:
    10.1089/scd.2016.0147 - link to the publication
  2. New reASOns to pursue the therapeutic potential of synthetic nucleic acids for neurological diseases
    Authors:
    Jill Sergesketter Butler, Marek Napierala
    Academic press:
    JAMA Neurology (rok: 2016, tom: 73 (10), strony: 1175-1177), Wydawca: AMER MEDICAL ASSOC, 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
    Status:
    Published
    DOI:
    10.1001/jamaneurol.2016.2571 - link to the publication
  3. Comprehensive Transcriptome Analysis Identifies FXN and BDNF as Novel Targets of miRNAs in Friedreich's Ataxia Patients
    Authors:
    Misiorek JO, Schreiber AM, Urbanek-Trzeciak MO, Jazurek-Ciesiołka M, Hauser LA, Lynch DR, Napierala JS, Napierala M
    Academic press:
    Mol Neurobiol. (rok: 2020, tom: 57, strony: 2639-2653), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-020-01899-1 - link to the publication

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