Role of microRNAs in regulation iron metabolism in Friedreich's ataxia
2015/19/B/NZ1/02804
Keywords
Descriptors
- NZ1_1: Biologia molekularna
- NZ2_2: Genomika, transkryptomika i epigenomika
- NZ3_5: Neurobiologia molekularna
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Instytut Chemii Bioorganicznej PAN
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 4
Call
OPUS 10 – announced on 2015-09-15
- Amount awarded
- 1 094 800 PLN
- Project start date
- 2016-07-14
- Project end date
- 2020-04-13
- Project duration
- 45 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Analizator RNA, DNA i bialek. Cost: 100 000 PLN
- Autoklaw.
- Komputer z oprogramowaniem (2 pcs). Cost: 12 000 PLN
- Termocykler Real-Time PCR.
Information in the final report
Publication in academic press/journals (3)
-
New reASOns to pursue the therapeutic potential of synthetic nucleic acids for neurological diseases
- Authors:
- Jill Sergesketter Butler, Marek Napierala
- Academic press:
- JAMA Neurology (year: 2016, volume: 73 (10), pages: 1175-1177), Publisher: AMER MEDICAL ASSOC, 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
- Status:
- Published
- DOI:
- 10.1001/jamaneurol.2016.2571 – link to the publication
-
Comprehensive Transcriptome Analysis Identifies FXN and BDNF as Novel Targets of miRNAs in Friedreich's Ataxia Patients
- Authors:
- Misiorek JO, Schreiber AM, Urbanek-Trzeciak MO, Jazurek-Ciesiołka M, Hauser LA, Lynch DR, Napierala JS, Napierala M
- Academic press:
- Mol Neurobiol. (year: 2020, volume: 57, pages: 2639-2653), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12035-020-01899-1 – link to the publication
-
Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming
- Authors:
- Urszula Polak, Yanjie Li, Jill Sergesketter Butler, Marek Napierala
- Academic press:
- Stem Cells And Development (year: 2016, volume: 25(23), pages: 1788–1800), Publisher: MARY ANN LIEBERT, INC, 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
- Status:
- Published
- DOI:
- 10.1089/scd.2016.0147 – link to the publication