Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of mitochondrial O-GlcNAc transferase isoform in glucose-dependent regulation of glycolytic activity in normal and cancer breast cells

2015/19/D/NZ3/01488

Keywords:

O-GlcNAcylation hyperglycemia oxidative phosphorylation mitochondrial mega-channels

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_2: Biochemistry

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paweł Jóźwiak 

Number of co-investigators in the project: 4

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 469 080 PLN

Project start date (Y-m-d): 2016-07-22

Project end date (Y-m-d): 2021-12-21

Project duration:: 65 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zamrażalka ultra-niskotemperaturowa (45 000 PLN)
  2. Inkubator mikrobiologiczny z wytrząsaniem.

Information in the final report

  • Publication in academic press/journals (2)
  1. Mitochondrial O-GlcNAc Transferase Interacts with and Modifies Many Proteins and Its Up-Regulation Affects Mitochondrial Function and Cellular Energy Homeostasis
    Authors:
    Paweł Jóźwiak, Piotr Ciesielski, Piotr K. Zakrzewski, Karolina Kozal, Joanna Oracz, Grażyna Budryn, Dorota Żyżelewicz, Stéphanie Flament, Anne-Sophie Vercoutter-Edouart, Fabrice Bray, Tony Lefebvre i Anna Krześlak
    Academic press:
    Cancers (rok: 2021, tom: 13, strony: 2956), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13122956 - link to the publication
  2. Increased O-GlcNAcylation by upregulation of mitochondrial 2 O-GlcNAc transferase (mOGT) inhibits the activity of respira-3 tory chain complexes and controls cellular bioenergetics.
    Authors:
    Paweł Jóźwiak , Joanna Oracz, Angela Dziedzic, Rafał Szelenberger, Dorota Żyżelewicz, Michał Bijak, Anna Krześlak
    Academic press:
    cancers (rok: 2024, tom: -, strony: -), Wydawca: MDPI
    Status:
    Submitted
    DOI:
    10.3390/xxxxx - link to the publication

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