Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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In vitro and in vivo preclinical studies of NaA nanozeolite functionalized with antibodies anti-PSMA and labeled with radium radioizotope for targeted prostate cancer therapy.

2015/19/B/NZ7/02166

Keywords:

functionalized nanozeolites NaA radium radionuclide PSMA receptor toxicity/radiotoxicity pharmacokinetics biodistribution

Descriptors:

  • NZ1_1: Molecular biology
  • NZ7_15: Toxicology
  • ST4_16: Ionic liquids

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Chemii i Techniki Jądrowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Anna Lankoff 

Number of co-investigators in the project: 12

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 804 400 PLN

Project start date (Y-m-d): 2016-09-08

Project end date (Y-m-d): 2021-03-07

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. zbiornik na ciekły azot do transportu próbek (15 000 PLN)
  2. inkubator CO2 do hodowli komórkowych in vitro (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Design and evaluation of novel 223Ra-labeled and anti-PSMA targeted NaA nanozeolite for prostate cancer therapy.
    Authors:
    Malwina Czerwińska, Giulio Fracasso, Marek Pruszyński, Aleksander Bilewicz, Marcin Kruszewski, Anna Lankoff
    Academic press:
    Materials (rok: 2020, tom: 13, strony: 3875), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma13173875 - link to the publication
  2. Design and evaluation 223Ra-labeled and anti-PSMA targeted NaA nanozeolites for prostate cancer therapy-Part II. Toxicity, pharmacokinetics and biodistribution
    Authors:
    Anna Lankoff, Malwina Czerwińska, Rafał Walczak, Urszula Karczmarczyk, Kamil Tomczyk, Kamil Brzóska, Giulio Fracasso, Piotr Garnuszek,Renata Mikołajczak, Marcin Kruszewski
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 5702), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22115702 - link to the publication
  3. Targeted Radionuclide Therapy of Prostate Cancer-From Basic Research to Clinical Perspectives
    Authors:
    Malwina Czerwińska, Aleksander Bilewicz, Marcin Kruszewski, Aneta Wegierek-Ciuk, Anna Lankoff
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 1743), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25071743 - link to the publication

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