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Selective inhibition of NMDAR activity during epileptogenesis as a therapeutic approach to cure epilepsy

2015/19/D/NZ7/02402

Keywords

Descriptors

  • NZ7_12: Prewencja chorób człowieka

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Adam Gorlewicz

Number of co-investigators in the project: 2

Call

SONATA 10 – announced on 2015-09-15

Amount awarded
763 000 PLN
Project start date
2016-07-20
Project end date
2021-07-19
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Digitalizer do rejestracji sygnału elektrofizjologicznego.
  2. Komora międzyfazowa. Cost: 8 000 PLN
  3. Komputerowa stacja do rejestracji i analizy sygnału elektrofizjologicznego i obrazu, wraz z oprogramowaniem i urządzeniami peryferycznymi.
  4. Laser. Cost: 9 000 PLN
  5. Platforma wraz z komorą zanurzeniową do patch clampa.
  6. Pompa infuzyjna. Cost: 11 000 PLN
  7. Pompa perystaltyczna.
  8. Stacja robocza do rejestracji i analizy EEG wraz z oprogramowaniem, monitorem i oprzyrządowaniem. Cost: 15 000 PLN
  9. Stół antywibracyjny. Cost: 20 000 PLN
  10. Urządzenie z wibrującym ostrzem (Wibratom). Cost: 62 000 PLN
  11. Wyciągarka do pipet. Cost: 32 000 PLN
  12. Zestaw dwóch mikromanipulatorów do patch clamp'a wraz z kontrolerem przesuwu.

Information in the final report

Publication in academic press/journals (3)

  1. Epileptiform GluN2B–driven excitation in hippocampus as a therapeutic target against temporal lobe epilepsy

    Authors:
    Adam Gorlewicz, Barbara Pijet, Krstina Orlova, Leszek Kaczmarek, Ewelina Knapska
    Academic press:
    bioRxive (year: 2021, volume: nie dotyczy, pages: nie dotyczy), Publisher: Cold Spring Harbor
    Status:
    Published
    DOI:
    10.1101/2021.06.30.450508 – link to the publication

  2. The deletion of GluK2 alters cholinergic control of neuronal excitability

    Authors:
    Adam Gorlewicz, Stefano Zucca, Gael Barthet, Peggy Vincent, Marilena Griguoli, Noëlle Grosjean, Grzegorz Wilczynski, Christophe Mulle
    Academic press:
    Cerebral Cortex (year: 2021, volume: 0, pages: 46038), Publisher: Oxford University Press
    Status:
    Published

  3. Colocalization Colormap -an ImageJ Plugin for the Quantification and Visualization of Colocalized Signals

    Authors:
    Adam Gorlewicz, Katarzyna Krawczyk, Andrzej A Szczepankiewicz, Pawel Trzaskoma, Christophe Mulle, Grzegorz M Wilczynski
    Academic press:
    Neuroinformatics (year: 2020, volume: 18, pages: 661–664), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12021-020-09465-9 – link to the publication

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Graphic design and implementation: Jakub Piotrowski