Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Selective inhibition of NMDAR activity during epileptogenesis as a therapeutic approach to cure epilepsy

2015/19/D/NZ7/02402

Keywords:

NMDAR epileptogenesis temporal lobe epilepsy mossy fibers

Descriptors:

  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Adam Gorlewicz 

Number of co-investigators in the project: 2

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 763 000 PLN

Project start date (Y-m-d): 2016-07-20

Project end date (Y-m-d): 2021-07-19

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora międzyfazowa (8 000 PLN)
  2. Wyciągarka do pipet (32 000 PLN)
  3. Stół antywibracyjny (20 000 PLN)
  4. Urządzenie z wibrującym ostrzem (Wibratom) (62 000 PLN)
  5. Digitalizer do rejestracji sygnału elektrofizjologicznego.
  6. Pompa perystaltyczna.
  7. Laser (9 000 PLN)
  8. Pompa infuzyjna (11 000 PLN)
  9. Stacja robocza do rejestracji i analizy EEG wraz z oprogramowaniem, monitorem i oprzyrządowaniem (15 000 PLN)
  10. Zestaw dwóch mikromanipulatorów do patch clamp'a wraz z kontrolerem przesuwu.
  11. Komputerowa stacja do rejestracji i analizy sygnału elektrofizjologicznego i obrazu, wraz z oprogramowaniem i urządzeniami peryferycznymi.
  12. Platforma wraz z komorą zanurzeniową do patch clampa.

Information in the final report

  • Publication in academic press/journals (3)
  1. Colocalization Colormap -an ImageJ Plugin for the Quantification and Visualization of Colocalized Signals
    Authors:
    Adam Gorlewicz, Katarzyna Krawczyk, Andrzej A Szczepankiewicz, Pawel Trzaskoma, Christophe Mulle, Grzegorz M Wilczynski
    Academic press:
    Neuroinformatics (rok: 2020, tom: 18, strony: 661–664), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12021-020-09465-9 - link to the publication
  2. The deletion of GluK2 alters cholinergic control of neuronal excitability
    Authors:
    Adam Gorlewicz, Stefano Zucca, Gael Barthet, Peggy Vincent, Marilena Griguoli, Noëlle Grosjean, Grzegorz Wilczynski, Christophe Mulle
    Academic press:
    Cerebral Cortex (rok: 2021, ), Wydawca: Oxford University Press
    Status:
    Published
  3. Epileptiform GluN2B–driven excitation in hippocampus as a therapeutic target against temporal lobe epilepsy
    Authors:
    Adam Gorlewicz, Barbara Pijet, Krstina Orlova, Leszek Kaczmarek, Ewelina Knapska
    Academic press:
    bioRxive (rok: 2021, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Cold Spring Harbor
    Status:
    Published
    DOI:
    10.1101/2021.06.30.450508 - link to the publication