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The role of kidneys and haem oxygenase 1 (HO-1) in iron metabolism and haem detoxification during neonatal hyperbilirubinemia - research based on laboratory mouse model

2015/19/N/NZ4/00998

Keywords:

kidneys iron metabolism neonatal hyperbilirubinemia haem oxygenase 1

Descriptors:

  • NZ4_11: Metabolism
  • NZ1_1: Molecular biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Aleksandra Bednarz 

Number of co-investigators in the project: 2

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 147 600 PLN

Project start date (Y-m-d): 2016-09-09

Project end date (Y-m-d): 2021-03-08

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Role of the kidneys in the redistribution of heme-derived iron during neonatal hemolysis in mice
    Authors:
    Aleksandra Bednarz, Mateusz Ogórek, Olga Pierzchała, Mateusz Tomczyk, Witold Nowak, Olga Mucha, Aneta Jończy, Robert Staroń, Rafał R. Starzyński, Paweł Lipiński, Julia Śmierzchalska, Zenon Rajfur, Zbigniew Baster, Alicja Józkowicz, Małgorzata Lenartowicz
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 11102), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-47414-y - link to the publication
  2. Exacerbation of neonatal hemolysis and impaired renal iron handling in heme oxygenase 1-deficient mice
    Authors:
    Aleksandra Bednarz, Paweł Lipiński, Rafał R. Starzyński, Mateusz Tomczyk, Izabela Kraszewska, Sylwia Herman, Kacper Kowalski, Ewelina Gruca, Aneta Jończy, Rafał Mazgaj, Mateusz Szudzik, Zenon Rajfur, Zbigniew Baster, Alicja Józkowicz, Małgorzata Lenartowicz
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 7754), Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/ijms21207754 - link to the publication

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