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The effects of exendin-4 on dermal fibroblast function and gene expression of proteins and microRNAs involved in the control of wound healing under diabetes mellitus: Ex vivo and in vitro studies.

2015/19/N/NZ4/03674

Keywords:

exendin-4 fibroblasts metalloproteinases CRP VEGF micrRNA diabetes

Descriptors:

  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Monika Wolak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2016-07-14

Project end date (Y-m-d): 2021-01-13

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (4)
  1. Anti-inflammatory and pro-healing impacts of exendin-4 treatment in Zucker diabetic rats: Effects on skin wound fibroblasts.
    Authors:
    Wolak Monika, Staszewska Teresa, Juszczak Marlena, Gałdyszyńska Małgorzata, Bojanowska Ewa
    Academic press:
    European Journal of Pharmacology (rok: 2019, tom: 842, strony: 262-269), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.053 - link to the publication
  1. Exendin-4 improves blood and tissue biochemical markers of inflammation and wound healing in Zucker diabetic rats
    Authors:
    Monika Wolak, Teresa Staszewska, Ewa Bojanowska
    Conference:
    Congress BIO 2018 (rok: 2018, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21 wrzesień
    Status:
    Published
  2. Migration activity of skin fibroblasts derived from Zucker diabetic rats treated with Exendin-4
    Authors:
    E.Bojanowska, T. Staszewska, M.Wolak
    Conference:
    27th Congress of the Polish Physiological Society (rok: 2017, ), Wydawca: The Polish Physiological Society
    Data:
    konferencja Białystok 21-22 Wrzesień 2017
    Status:
    Published
  3. Wpływ eksendyny-4 na metabolizm otyłych szczurów szczepu Zucker
    Authors:
    Wolak Monika, Staszewska Teresa, Bojanowska Ewa
    Conference:
    Badania i Rozwój Młodych Naukowców w Polce 2017 (rok: 2017, ), Wydawca: Młodzi Naukowcy
    Data:
    konferencja Poznań 08 Maj 2017
    Status:
    Published
  4. The EX VIVO and IN VITRO Exendin-4 effects on the metabolic activity of diabetic rat wound fibroblasts
    Authors:
    M. Wolak, T. Staszewska, E. Bojanowska
    Conference:
    27th Congress of the Polish Physiological Society (rok: 2017, ), Wydawca: The Polish Physiological Society
    Data:
    konferencja Białystok 21-22 Wrzesień 2017
    Status:
    Published

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