Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The effect of knockout and overexpression of CD73 on aortic valve dysfunction and mechanism of this pathology.

2015/19/N/NZ1/03435

Keywords:

Valvular pathologies Aortic stenosis Lipid and carbohydrate metabolism disorders CD73 ecto-5'-nucleotidase Adenosine

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ4_11: Metabolism
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paulina Mierzejewska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 10 - announced on 2015-09-15

Amount awarded: 149 900 PLN

Project start date (Y-m-d): 2016-09-28

Project end date (Y-m-d): 2019-09-27

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zamrażarka niskotemperaturowa.
  2. Aparatura do Western Blot z pełnym wyposażeniem (21 500 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Impaired L-arginine metabolism marks endothelial dysfunction in CD73-deficient mice
    Authors:
    Mierzejewska P, Zabielska MA, Kutryb-Zajac B, Tomczyk M, Koszalka P, Smolenski RT, Slominska EM
    Academic press:
    Molecular and Cellular Biochemistry (rok: 2019, tom: 458, strony: 133-142), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11010-019-03537-4 - link to the publication
  2. Deletion of CD73 in mice leads to aortic valve dysfunction.
    Authors:
    Zukowska P, Kutryb-Zajac B, Jasztal A, Toczek M, Zabielska M, Borkowski T, Khalpey Z, Smolenski RT, Slominska EM
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (rok: 2017, tom: 1863, Issue 6, strony: 1464-1472), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2017.02.008. - link to the publication

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