The effect of knockout and overexpression of CD73 on aortic valve dysfunction and mechanism of this pathology.
2015/19/N/NZ1/03435
Keywords
Descriptors
- NZ4_4: Patofizjologia ogólna
- NZ4_11: Metabolizm
- NZ1_2: Biochemia
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Gdański Uniwersytet Medyczny, Wydział Lekarski
Voivodeship: pomorskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 10 – announced on 2015-09-15
- Amount awarded
- 149 900 PLN
- Project start date
- 2016-09-28
- Project end date
- 2019-09-27
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Aparatura do Western Blot z pełnym wyposażeniem. Cost: 21 500 PLN
- Zamrażarka niskotemperaturowa.
Information in the final report
Publication in academic press/journals (2)
-
Impaired L-arginine metabolism marks endothelial dysfunction in CD73-deficient mice
- Authors:
- Mierzejewska P, Zabielska MA, Kutryb-Zajac B, Tomczyk M, Koszalka P, Smolenski RT, Slominska EM
- Academic press:
- Molecular and Cellular Biochemistry (year: 2019, volume: 458, pages: 133-142), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s11010-019-03537-4 – link to the publication
-
Deletion of CD73 in mice leads to aortic valve dysfunction.
- Authors:
- Zukowska P, Kutryb-Zajac B, Jasztal A, Toczek M, Zabielska M, Borkowski T, Khalpey Z, Smolenski RT, Slominska EM
- Academic press:
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (year: 2017, volume: 1863, Issue 6, pages: 1464-1472), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bbadis.2017.02.008. – link to the publication