Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The role of MCPIP1 protein in growth, progression and vascularisation of clear cell renal cell carcinoma.

2015/19/B/NZ5/01405

Keywords:

MCPIP1 protein tumor growth metastasis angiogenesis

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Miękus 

Number of co-investigators in the project: 7

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 788 400 PLN

Project start date (Y-m-d): 2016-06-23

Project end date (Y-m-d): 2021-06-22

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. cytometr przepływowy (160 000 PLN)
  2. komputer (5 000 PLN)
  3. lodówka (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. MCPIP1 inhibits Wnt/β-catenin signaling pathway activity and modulates epithelial-mesenchymal transition during clear cell renal cell carcinoma progression by targeting miRNAs
    Authors:
    Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Agnieszka Waligórska, Ewelina Pospiech, Jurek W Dobrucki, Janusz Rys, Jolanta Jura, Katarzyna Miekus
    Academic press:
    Oncogene (rok: 2021, tom: 50, strony: 6720-6735), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41388-021-02062-3 - link to the publication
  2. The anti-inflammatory protein MCPIP1 inhibits the development of ccRCC by maintaining high levels of tumour suppressors
    Authors:
    Judyta Gorka, Paulina Marona, Oliwia Kwapisz, Janusz Rys, Jolanta Jura, Katarzyna Miekus
    Academic press:
    European Journal of Pharmacology (rok: 2020, tom: 888, strony: 173591), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016􏱝􏰎.e􏰎phar.2020.173591 - link to the publication
  3. MCPIP1 downregulation in clear cell renal cell carcinoma promotes vascularization and metastatic progression
    Authors:
    Marona P, Górka J., Mazurek Z, Wilk W, Rys J, Majka M, Jura J, Miekus K
    Academic press:
    Cancer Research (rok: 2017, tom: Sep 15;77(18), strony: 4905-4920), Wydawca: AACR
    Status:
    Published
    DOI:
    10.1158/0008-5472 - link to the publication
  4. C-Met as a Key Factor Responsible for Sustaining Undifferentiated Phenotype and Therapy Resistance in Renal Carcinomas
    Authors:
    Paulina Marona , Judyta Górka, Jerzy Kotlinowski, Marcin Majka , Jolanta Jura, Katarzyna Miekus
    Academic press:
    Cells (rok: 2019, tom: 272, strony: 8; MDPI używa nr artykułów, zamiast nr stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8030272 - link to the publication
  1. RNase activity of MCPIP1 regulates key elements of mesenchymal phenotype of clear cell renal cell carcinoma cells
    Authors:
    Miekus, K; Marona, P ; Gorka, J; Jura, J
    Conference:
    Annual Meeting of the American-Association-for-Cancer-Research (AACR) (rok: 2018, ), Wydawca: Cancer Research
    Data:
    konferencja APR 14-18, 2018
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy