Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Impact of surgical wound fluids from patients after intraoperative radiotherapy on the reduction of tumorigenic potential as an indirect effect of radiation

2015/19/D/NZ5/02190

Keywords:

breast cancer intraoperative radiotherapy radiation induced bystander effect

Descriptors:

  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Kulcenty 

Number of co-investigators in the project: 2

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 481 040 PLN

Project start date (Y-m-d): 2016-07-13

Project end date (Y-m-d): 2021-07-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer przenośny (laptop) (4 000 PLN)
  2. Wirówka Centrifuge 5424 R (EU-IVD), z chłodzeniem, zawiera Rotor FA-45-24-11, klawiatura, 230 V/50 – 60 Hz.
  3. Oprogramowanie do analiz cytometrycznych (FlowJo) (20 000 PLN)
  4. Zamrażarka na -80 stopni (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Biologiczne aspekty śródoperacyjnej radioterapii i roli płynów pooperacyjnych w terapii raka piersi
    Authors:
    Igor Piotrowski, Katarzyna Kulcenty, Dawid Murawa, Wiktoria Suchorska
    Academic press:
    Zeszyty Naukowe WCO, Letters in Oncology Science 2016 (rok: 2016, tom: 13(2), strony: 30-37), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Intraoperative Radiotherapy of Breast Cancer and Its Biological Effects.
    Authors:
    Piotrowski I, Kulcenty K, Wichtowski M, Murawa D, Suchorska W.
    Academic press:
    Breast Care (rok: 2017, tom: 12(2), strony: 109-113), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000454673 - link to the publication
  3. Surgical wound fluids from patients with breast cancer reveal similarities in the biological response induced by intraoperative radiation therapy and the radiation-induced bystander effect – transcriptomic approach
    Authors:
    Kulcenty K., Piotrowski I., Rucinski M., Wroblewska JP., Jopek K., Murawa D., Suchorska WM
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(3), strony: brak), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21031159 - link to the publication
  4. The composition of surgical wound fluids from breast cancer patients is affected by intraoperative radiotherapy treatment and depends on the molecular subtype of breast cancer
    Authors:
    Kulcenty K., Piotrowski I, Wroblewska JP., Wasiewicz J., Suchorska WM
    Academic press:
    Cancers (rok: 2019, tom: 12(1), strony: brak), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12010011 - link to the publication
  5. Interplay between inflammation and cancer
    Authors:
    Igor Piotrowski, Katarzyna Kulcenty, Wiktoria Suchorska
    Academic press:
    Reports of Practical Oncology and Radiotherapy (rok: 2020, tom: 25, strony: 422-427), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.rpor.2020.04.004 - link to the publication
  6. Surgical wound fluids from patients treated with intraoperative radiotherapy induce radiobiological response in breast cancer cells
    Authors:
    Piotrowski I, Kulcenty K, Murawa D, Suchorska W.
    Academic press:
    Medical Oncology (rok: 2018, tom: 36, strony: 45303), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12032-018-1243-z - link to the publication
  7. Wound fluids collected from patients after IORT treatment activates extrinsic apoptotic pathway in MCF7 breast cancer cell line
    Authors:
    Kulcenty Katarzyna, Piotrowski Igor , Zaleska Karolina, Murawa Dawid, Suchorska Wiktoria
    Academic press:
    Ginekologia Polska (rok: 2018, tom: 89/4, strony: 175-181), Wydawca: Via Medica Journals
    Status:
    Published
    DOI:
    10.5603/GP.a2018.0030 - link to the publication
  8. Wound fluids collected postoperatively from patients with breast cancer induce epithelial to mesenchymal transition but intraoperative radiotherapy impairs this effect by activating the radiation-induced bystander effect
    Authors:
    Katarzyna Kulcenty, Igor Piotrowski, Karolina Zaleska, , Mateusz Wichtowski, Joanna Wróblewska, Dawid Murawa, Wiktoria Suchorska
    Academic press:
    Scientific Reports (rok: 2019, tom: brak, strony: brak), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    brak - link to the publication

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