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Molecular mechanism of atherosclerosis progression in chronic kidney disease

2015/19/B/NZ2/02450

Keywords

Descriptors

  • NZ2_3: Proteomika
  • NZ2_9: Biologia systemowa
  • NZ2_11: Epidemiologia genetyczna

Panel

NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution

Instytut Chemii Bioorganicznej PAN

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Magdalena Łuczak

Number of co-investigators in the project: 7

Call

OPUS 10 – announced on 2015-09-15

Amount awarded
893 817 PLN
Project start date
2016-06-20
Project end date
2021-12-19
Project duration
66 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie STATISTICA Zestaw Medyczny. Cost: 10 000 PLN
  2. Oprogramowanie do analizy lipidomu, SimLipid. Cost: 58 000 PLN
  3. Zbiornik kriogeniczny do przechowywania materiału biologicznego.
  4. Zestaw komputerowy wraz z oprogramowaniem (Windows, Office). Cost: 5 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Proteomic profiling of leukocytes reveals dysregulation of adhesion and integrin proteins in chronic kidney disease-related atherosclerosis

    Authors:
    Joanna Tracz, Luiza Handschuh, Maciej Lalowski, Łukasz Marczak, Katarzyna Kostka-Jeziorny, Bartłomiej Perek, Maria Wanic-Kossowska, Alina Podkowińska, Andrzej Tykarski, Dorota Formanowicz, and Magdalena Luczak
    Academic press:
    Journal of Proteome Research (year: 2021, volume: 20, 6, pages: 3053–3067), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jproteome.0c00883 – link to the publication

  2. Applying Proteomics and Integrative Omics Strategies to Decipher the Chronic Kidney Disease-Related Atherosclerosis

    Authors:
    Joanna Tracz, Magdalena Luczak
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 7492), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22147492 – link to the publication

  3. iTRAQ-based proteomic analysis of plasma reveals abnormalities in lipid metabolism proteins in chronic kidney disease-related atherosclerosis

    Authors:
    Magdalena Luczak, Dorota Formanowicz, Łukasz Marczak, Joanna Suszyńska-Zajczyk, Elżbieta Pawliczak, Maria Wanic-Kossowska & Maciej Stobiecki
    Academic press:
    Scientific Reports (year: 2016, volume: 6, pages: 32511), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep32511 – link to the publication

  4. Mass spectrometry-based lipidomics reveals differential changes in the accumulated lipid classes in chronic kidney disease

    Authors:
    Lukasz Marczak, Jakub Idkowiak, Joanna Tracz, Maciej Stobiecki, Bartłomiej Perek, Katarzyna Kostka-Jeziorny, Andrzej Tykarski, Maria Wanic-Kossowska, Marcin Borowski, Marcin Osuch, Dorota Formanowicz and Magdalena Luczak
    Academic press:
    Metabolites (year: 2021, volume: 11, pages: 275), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/metabo11050275 – link to the publication

Articles in post-conference publications (8)

  1. Analysis of the CD14+ monocytes proteome in atherosclerosis related and non-related to chronic kidney disease

    Authors:
    J. Tracz
    Conference:
    World Structural and Molecular Biology Conference, Rome Italy (year: 2018, pages: 35), Publisher: Cenetri Publishing Group
    Date:
    conference November 26-28, 2018
    Status:
    Published

  2. LC-MS/MS analysis of the monocytes CD14+ proteome in atherosclerosis related and non-related to chronic kidney disease

    Authors:
    J. Tracz, K. Kostka-Jeziorny, B. Perek, A. Podkowińska, D. Formanowicz, M. Luczak
    Conference:
    BIO 2018 - 3nd Congress, Gdańsk (year: 2018, pages: Acta Bioch. Pol. Vol. 65, suppl. 2, pp. 126), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Date:
    conference 8 – 21.09.2018
    Status:
    Published

  3. Lipidomic analysis of patients suffering from cardiovascular disease related to chronic kidney disease

    Authors:
    Ł. Marczak, J. Idkowiak, J. Tracz, M. Łuczak, B. Perek, K. Kostka-Jeziorny, A. Podkowińska, M. Stobiecki
    Conference:
    6th Conference of Polish Mass Spectrometry Society, Miedzeszyn (year: 2018, pages: Materiały konferencyjne: str.67), Publisher: Instytut Chemii Organicznej PAN
    Date:
    conference 22-26.04.2018
    Status:
    Published

  4. Analysis of serum lipid fraction of patients suffering from cardiovascular disease related to chronic kidney disease

    Authors:
    Ł. Marczak, J. Idkowiak, J. Tracz, M. Łuczak, B. Perek, K. Kostka-Jeziorny, A. Podkowińska, M. Stobiecki
    Conference:
    BIO 2018 - 3nd Congress Gdańsk (year: 2018, pages: Acta Bioch. Pol. Vol. 65, suppl. 2, pp. 101), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN.
    Date:
    conference 18 – 21.09.2018
    Status:
    Published

  5. LC-MS/MS analysis of the leukocytes proteome and oxidative stress biomarkers in atherosclerosis related and non-related to chronic kidney disease

    Authors:
    J. Tracz, K. Kostka-Jeziorny, B. Perek, A. Podkowińska, D. Formanowicz, M. Luczak
    Conference:
    6th Conference of Polish Mass Spectrometry Society, Miedzeszyn (year: 2018, pages: Materiały konferencyjne: str. 51), Publisher: Instytut Chemii Organicznej
    Date:
    conference 22-26.04.2018
    Status:
    Published

  6. Proteomic analysis of monocytes in cardiovascular disease related to chronic kidney disease

    Authors:
    J. Tracz, K. Kostka-Jeziorny, B. Perek, A. Podkowińska, D. Formanowicz, M. Łuczak
    Conference:
    13th Central and Eastern European Proteomic Conference, Ustroń (year: 2019, pages: YG-6), Publisher: Institute Oncology Center Gliwice
    Date:
    conference 23-25.09.2019
    Status:
    Published

  7. Analiza proteomiczna komórek układu immunologicznego w progresji miażdżycy związanej z przewlekłą chorobą nerek

    Authors:
    J. Tracz, K. Kostka-Jeziorny, B. Perek, A. Podkowińska, D. Formanowicz, M. Łuczak
    Conference:
    BioOrg 2019 III Ogólnopolskie Sympozjum Chemii Bioorganicznej, Organicznej i Biomateriałów, Poznań, (year: 2019, pages: 181-183), Publisher: Instytut Technologii Chemicznej PP
    Date:
    conference 43806
    Status:
    Published

  8. Multi-omic insights into the pathomechanism of chronic kidney disease-related atherosclerosis

    Authors:
    J. Tracz, L. Handschuh, M. Lalowski, L. Marczak, K. Kostka-Jeziorny, B. Perek, M. Wanic-Kossowska, A. Podkowinska, A. Tykarski, D. Formanowicz, M. Luczak.
    Conference:
    28th Congress of the Polish Physiological Society (year: 2021, pages: 159), Publisher: Journal of Physiology and Pharmacology
    Date:
    conference 2021.09.15-17
    Status:
    Published

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