Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanism of atherosclerosis progression in chronic kidney disease

2015/19/B/NZ2/02450

Keywords:

chronic kidney disease atherosclerosis mass spectrometry cytokines

Descriptors:

  • NZ2_3: Proteomics
  • NZ2_9: Systems biology
  • NZ2_11: Genetic epidemiology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Łuczak 

Number of co-investigators in the project: 7

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 893 817 PLN

Project start date (Y-m-d): 2016-06-20

Project end date (Y-m-d): 2021-12-19

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie do analizy lipidomu, SimLipid (58 000 PLN)
  2. Zbiornik kriogeniczny do przechowywania materiału biologicznego.
  3. Oprogramowanie STATISTICA Zestaw Medyczny (10 000 PLN)
  4. Zestaw komputerowy wraz z oprogramowaniem (Windows, Office) (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (8)
  1. Proteomic profiling of leukocytes reveals dysregulation of adhesion and integrin proteins in chronic kidney disease-related atherosclerosis
    Authors:
    Joanna Tracz, Luiza Handschuh, Maciej Lalowski, Łukasz Marczak, Katarzyna Kostka-Jeziorny, Bartłomiej Perek, Maria Wanic-Kossowska, Alina Podkowińska, Andrzej Tykarski, Dorota Formanowicz, and Magdalena Luczak
    Academic press:
    Journal of Proteome Research (rok: 2021, tom: 20, 6, strony: 3053–3067), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jproteome.0c00883 - link to the publication
  2. Applying Proteomics and Integrative "Omics" Strategies to Decipher the Chronic Kidney Disease-Related Atherosclerosis
    Authors:
    Joanna Tracz, Magdalena Luczak
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 7492), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22147492 - link to the publication
  3. Mass spectrometry-based lipidomics reveals differential changes in the accumulated lipid classes in chronic kidney disease
    Authors:
    Lukasz Marczak, Jakub Idkowiak, Joanna Tracz, Maciej Stobiecki, Bartłomiej Perek, Katarzyna Kostka-Jeziorny, Andrzej Tykarski, Maria Wanic-Kossowska, Marcin Borowski, Marcin Osuch, Dorota Formanowicz and Magdalena Luczak
    Academic press:
    Metabolites (rok: 2021, tom: 11, strony: 275), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/metabo11050275 - link to the publication
  4. iTRAQ-based proteomic analysis of plasma reveals abnormalities in lipid metabolism proteins in chronic kidney disease-related atherosclerosis
    Authors:
    Magdalena Luczak, Dorota Formanowicz, Łukasz Marczak, Joanna Suszyńska-Zajczyk, Elżbieta Pawliczak, Maria Wanic-Kossowska & Maciej Stobiecki
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: 32511), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep32511 - link to the publication
  1. Analysis of serum lipid fraction of patients suffering from cardiovascular disease related to chronic kidney disease
    Authors:
    Ł. Marczak, J. Idkowiak, J. Tracz, M. Łuczak, B. Perek, K. Kostka-Jeziorny, A. Podkowińska, M. Stobiecki
    Conference:
    BIO 2018 - 3nd Congress Gdańsk (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN.
    Data:
    konferencja 18 – 21.09.2018
    Status:
    Published
  2. Analysis of the CD14+ monocytes proteome in atherosclerosis related and non-related to chronic kidney disease
    Authors:
    J. Tracz
    Conference:
    World Structural and Molecular Biology Conference, Rome Italy (rok: 2018, ), Wydawca: Cenetri Publishing Group
    Data:
    konferencja November 26-28, 2018
    Status:
    Published
  3. LC-MS/MS analysis of the monocytes CD14+ proteome in atherosclerosis related and non-related to chronic kidney disease
    Authors:
    J. Tracz, K. Kostka-Jeziorny, B. Perek, A. Podkowińska, D. Formanowicz, M. Luczak
    Conference:
    BIO 2018 - 3nd Congress, Gdańsk (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 8 – 21.09.2018
    Status:
    Published
  4. Lipidomic analysis of patients suffering from cardiovascular disease related to chronic kidney disease
    Authors:
    Ł. Marczak, J. Idkowiak, J. Tracz, M. Łuczak, B. Perek, K. Kostka-Jeziorny, A. Podkowińska, M. Stobiecki
    Conference:
    6th Conference of Polish Mass Spectrometry Society, Miedzeszyn (rok: 2018, ), Wydawca: Instytut Chemii Organicznej PAN
    Data:
    konferencja 22-26.04.2018
    Status:
    Published
  5. LC-MS/MS analysis of the leukocytes proteome and oxidative stress biomarkers in atherosclerosis related and non-related to chronic kidney disease
    Authors:
    J. Tracz, K. Kostka-Jeziorny, B. Perek, A. Podkowińska, D. Formanowicz, M. Luczak
    Conference:
    6th Conference of Polish Mass Spectrometry Society, Miedzeszyn (rok: 2018, ), Wydawca: Instytut Chemii Organicznej
    Data:
    konferencja 22-26.04.2018
    Status:
    Published
  6. Multi-omic insights into the pathomechanism of chronic kidney disease-related atherosclerosis
    Authors:
    J. Tracz, L. Handschuh, M. Lalowski, L. Marczak, K. Kostka-Jeziorny, B. Perek, M. Wanic-Kossowska, A. Podkowinska, A. Tykarski, D. Formanowicz, M. Luczak.
    Conference:
    28th Congress of the Polish Physiological Society (rok: 2021, ), Wydawca: Journal of Physiology and Pharmacology
    Data:
    konferencja 2021.09.15-17
    Status:
    Published
  7. Proteomic analysis of monocytes in cardiovascular disease related to chronic kidney disease
    Authors:
    J. Tracz, K. Kostka-Jeziorny, B. Perek, A. Podkowińska, D. Formanowicz, M. Łuczak
    Conference:
    13th Central and Eastern European Proteomic Conference, Ustroń (rok: 2019, ), Wydawca: Institute Oncology Center Gliwice
    Data:
    konferencja 23-25.09.2019
    Status:
    Published
  8. Analiza proteomiczna komórek układu immunologicznego w progresji miażdżycy związanej z przewlekłą chorobą nerek
    Authors:
    J. Tracz, K. Kostka-Jeziorny, B. Perek, A. Podkowińska, D. Formanowicz, M. Łuczak
    Conference:
    BioOrg 2019 III Ogólnopolskie Sympozjum Chemii Bioorganicznej, Organicznej i Biomateriałów, Poznań, (rok: 2019, ), Wydawca: Instytut Technologii Chemicznej PP
    Data:
    konferencja 43806
    Status:
    Published