Allopregnanolone, as a major central factor affecting secretory activity of the hypothalamic-pituitary-adrenal axis and its stress response in pregnant sheep
2015/19/B/NZ9/03706
Keywords
Descriptors
- NZ9_2: Naukowe podstawy zootechniki
- NZ4_8: Neuroendokrynologia
- NZ4_6: Endokrynologia
Panel
NZ9 – Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation
Host institution
Instytut Fizjologii i Żywienia Zwierząt im. Jana Kielanowskiego PAN
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 8
Call
OPUS 10 – announced on 2015-09-15
- Amount awarded
- 1 192 060 PLN
- Project start date
- 2016-06-28
- Project end date
- 2019-12-27
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Eppendorf ThermoStat™ C z wkładem wymiennym typu SmartBlock na 24 probówki. Cost: 10 000 PLN
- Karta sterująca do urządzenia GC-MS.
- Komora laminarna do PCR z lampą UV i stołem. Cost: 12 000 PLN
- Pompa do perfuzji push-pull (mikroiniekcyjna) CMA 402 i strzykawki 4 szt.. Cost: 30 000 PLN
- Recyrkulator UVR-M. Cost: 2 200 PLN
- System do otrzymywania ultra-czystej wody. Cost: 80 000 PLN
- System do wizualizacji żeli. Cost: 25 000 PLN
- Wirówka MiniSpin® z rotorem. Cost: 5 000 PLN
- Wirówka laboratoryjna z rotorem. Cost: 16 835 PLN
Information in the final report
Publication in academic press/journals (4)
-
Allopregnanolone reduces neuroendocrine response to acute stressful stimuli in sheep
- Authors:
- Tomasz Misztal, Patrycja Młotkowska, Elżbieta Marciniak, Anna Misztal
- Academic press:
- Journal of Endocrinology (year: 2020, volume: 244, pages: 201-211), Publisher: Bioscientifica Ltd
- Status:
- Published
- DOI:
- 10.1530/JOE-19-0376 – link to the publication
-
Temporal changes in the cerebrospinal fluid allopregnanolone concentration and hypothalamic-pituitary-adrenal axis activity in sheep during pregnancy and early lactation
- Authors:
- Tomasz Misztal, Marian R. Czauderna, Patrycja Młotkowska, Anna Misztal, Elżbieta Marciniak
- Academic press:
- Livestock Science (year: 2020, volume: 231, pages: Article 103871), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.livsci.2019.103871 – link to the publication
-
The effect of allopregnanolone on enzymatic activity of the DNA base excision repair pathway in the sheep hippocampus and amygdala under natural and stressful conditions
- Authors:
- Tomasz Misztal, Paweł Kowalczyk, Patrycja Młotkowska, Elżbieta Marciniak
- Academic press:
- International Journal of Molecular Sciences (year: 2020, volume: 21, pages: ID 7762), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms21207762 – link to the publication
-
Effects of allopregnanolone on central reproductive functions in sheep under natural and stressful conditions
- Authors:
- Patrycja Młotkowska, Elżbieta Marciniak, Katarzyna Roszkowicz-Ostrowska, Tomasz Misztal
- Academic press:
- Theriogenology (year: 2020, volume: 158, pages: 138-147), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.theriogenology.2020.09.010 – link to the publication