Projects funded by the NCN
Allopregnanolone, as a major central factor affecting secretory activity of the hypothalamic-pituitary-adrenal axis and its stress response in pregnant sheep
2015/19/B/NZ9/03706
Keywords:
physiology of pregnancy stress response hypothalamus pituitary adrenals allopregnanolone brain-derived neurotrophic factor CRH ACTH cortisol salsolinol
Descriptors:
- NZ9_2: Animal production
- NZ4_8: Neuroendocrinology
- NZ4_6: Endocrinology
Panel:
NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation
Host institution :
Instytut Fizjologii i Żywienia Zwierząt im. Jana Kielanowskiego Polskiej Akademii Nauk
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 8
Call: OPUS 10 - announced on 2015-09-15
Amount awarded: 1 192 060 PLN
Project start date (Y-m-d): 2016-06-28
Project end date (Y-m-d): 2019-12-27
Project duration:: 42 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- System do otrzymywania ultra-czystej wody (80 000 PLN)
- System do wizualizacji żeli (25 000 PLN)
- Eppendorf ThermoStat™ C z wkładem wymiennym typu SmartBlock na 24 probówki (10 000 PLN)
- Karta sterująca do urządzenia GC-MS.
- Pompa do perfuzji push-pull (mikroiniekcyjna) CMA 402 i strzykawki 4 szt. (30 000 PLN)
- Wirówka MiniSpin® z rotorem (5 000 PLN)
- Komora laminarna do PCR z lampą UV i stołem (12 000 PLN)
- Wirówka laboratoryjna z rotorem (16 835 PLN)
- Recyrkulator UVR-M (2 200 PLN)
Information in the final report
- Publication in academic press/journals (4)
- The effect of allopregnanolone on enzymatic activity of the DNA base excision repair pathway in the sheep hippocampus and amygdala under natural and stressful conditionsAuthors:Tomasz Misztal, Paweł Kowalczyk, Patrycja Młotkowska, Elżbieta MarciniakAcademic press:International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: ID 7762), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms21207762 - link to the publication
- Allopregnanolone reduces neuroendocrine response to acute stressful stimuli in sheepAuthors:Tomasz Misztal, Patrycja Młotkowska, Elżbieta Marciniak, Anna MisztalAcademic press:Journal of Endocrinology (rok: 2020, tom: 244, strony: 201-211), Wydawca: Bioscientifica LtdStatus:PublishedDOI:10.1530/JOE-19-0376 - link to the publication
- Temporal changes in the cerebrospinal fluid allopregnanolone concentration and hypothalamic-pituitary-adrenal axis activity in sheep during pregnancy and early lactationAuthors:Tomasz Misztal, Marian R. Czauderna, Patrycja Młotkowska, Anna Misztal, Elżbieta MarciniakAcademic press:Livestock Science (rok: 2020, tom: 231, strony: Article 103871), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.livsci.2019.103871 - link to the publication
- Effects of allopregnanolone on central reproductive functions in sheep under natural and stressful conditionsAuthors:Patrycja Młotkowska, Elżbieta Marciniak, Katarzyna Roszkowicz-Ostrowska, Tomasz MisztalAcademic press:Theriogenology (rok: 2020, tom: 158, strony: 138-147), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.theriogenology.2020.09.010 - link to the publication