Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Vitamin B12 and mycobacterial persistence.

2015/19/D/NZ6/03011

Keywords:

Mycobacterium smegmatis tuberculosis stringent response persistence

Descriptors:

  • NZ6_4: Bacteriology
  • NZ1_10: Microbiology
  • NZ1_1: Molecular biology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Biologii Medycznej Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Alina Minias 

Number of co-investigators in the project: 3

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 770 600 PLN

Project start date (Y-m-d): 2016-10-05

Project end date (Y-m-d): 2019-12-04

Project duration:: 38 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. cytometr przepływowy (200 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Functional Disassociation Between the Protein Domains of MSMEG_4305 of Mycolicibacterium smegmatis (Mycobacterium smegmatis) in vivo
    Authors:
    Czubat B., Minias A.*, A. Brzostek, A. Zaczek, Struś K., Zakrzewska-Czerwińska J. J. Dziadek*
    Academic press:
    Frontiers in Microbiology (rok: 2020, tom: 11, strony: 2008), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fmicb.2020.02008 - link to the publication
  2. Targeting DNA repair systems in antitubercular drug development.
    Authors:
    Minias Alina, Brzostek Anna, Dziadek Jarosław
    Academic press:
    Current Medicinal Chemistry (rok: 2019, tom: 26, strony: 1494-1505), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/0929867325666180129093546 - link to the publication
  3. Cobalamin is present in cells of non-tuberculous mycobacteria, but not in Mycobacterium tuberculosis
    Authors:
    Minias Alina, Filip Gąsior, Brzostek Anna, Jagielski Tomasz, Adam Heather, Dziadek Jarosław
    Academic press:
    EMBO Reports (rok: 2021, tom: brak, strony: brak), Wydawca: EMBO Press
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Mycobacterium tuberculosis cholesterol-dependent transcriptome remodeling: New insight into the contribution of cholesterol to tubercle bacillus pathogenesis
    Authors:
    Jakub Pawełczyk, Anna Brzostek, Alina Minias, Przemysław Płociński, Anna Rumijowska-Galewicz , Dominik Strapagiel , Jolanta Zakrzewska-Czerwińska , Jarosław Dziadek
    Academic press:
    mBio (rok: 2021, tom: brak, strony: brak), Wydawca: ASM
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Purifying selective pressure suggests functionality of vitamin B12 biosynthesis pathway in a global population of Mycobacterium tuberculosis
    Authors:
    Alina Minias, Piotr Minias, Bożena Czubat, Jarosław Dziadek
    Academic press:
    Genome Biology and Evolution (rok: 2018, tom: Volume 10, strony: 2326–2337), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    brak - link to the publication

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