Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Biochemical reconstitution of key steps of mitochondrial iron-sulfur cluster (FeS) biogenesis

2015/19/B/NZ1/00237

Keywords:

mitochondria iron sulfur clusters yeast Hsp70 J-domain proteins

Descriptors:

  • NZ1_1:
  • NZ1_2:
  • NZ1_4:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Rafał Dominik Dutkiewicz 

Number of co-investigators in the project: 4

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 083 200 PLN

Project start date (Y-m-d): 2016-06-27

Project end date (Y-m-d): 2020-06-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Łaźnia wodna z wytrząsaniem.
  2. aparatura do pomiaru oddziaływania pomiędzy makrocząsteczkami BLItz.
  3. spektrometr dichroizmu kołowego z osprzętem (500 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Fe–S Cluster Hsp70 Chaperones: The ATPase Cycle and Protein Interactions
    Authors:
    Rafal Dutkiewicz, Malgorzata Nowak, Elizabeth A. Craig, Jaroslaw Marszalek
    Academic press:
    Methods in Enzymology, (rok: 2017, tom: 595, strony: 161-184), Wydawca: ELSEVIER ACADEMIC PRESS INC
    Status:
    Published
    DOI:
    10.1016/bs.mie.2017.07.004 - link to the publication
  2. Molecular chaperones involved in mitochondrial iron–sulfur protein biogenesis
    Authors:
    Rafal Dutkiewicz, Malgorzata Nowak
    Academic press:
    J Biol Inorg Chem (rok: 2017, tom: 1, strony: 45668), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00775-017-1504-x - link to the publication
  3. Biochemical Convergence of Mitochondrial Hsp70 System Specialized in Iron-Sulfur Cluster Biogenesis.
    Authors:
    Malgorzata Kleczewska, Aneta Grabinska, Marcin Jelen, Milena Stolarska, Brenda Schilke, Elizabeth A. Craig, Jaroslaw Marszalek, Rafal Dutkiewicz
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 45671), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21093326 - link to the publication
  4. Biochemical Convergence of Mitochondrial Hsp70 System Specialized in Iron-Sulfur Cluster Biogenesis.
    Authors:
    Malgorzata Kleczewska, Aneta Grabinska, Marcin Jelen, Milena Stolarska, Brenda Schilke, Elizabeth A. Craig, Jaroslaw Marszalek, Rafal Dutkiewicz
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 45671), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21093326 - link to the publication
  5. During FeS-cluster biogenesis ferredoxin and frataxin use overlapping binding sites on yeast cysteine desulfurase Nfs1
    Authors:
    Marta A. Uzarska, Igor Grochowina, Joanna Soldek, Marcin Jelen, Brenda Schilke, Jaroslaw Marszalek, Elizabeth A. Craig, Rafal Dutkiewicz
    Status:
    Accepted for publication

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