Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Biochemical reconstitution of key steps of mitochondrial iron-sulfur cluster (FeS) biogenesis

2015/19/B/NZ1/00237

Keywords:

mitochondria iron sulfur clusters yeast Hsp70 J-domain proteins

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Rafał Dutkiewicz 

Number of co-investigators in the project: 4

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 083 200 PLN

Project start date (Y-m-d): 2016-06-27

Project end date (Y-m-d): 2020-06-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Łaźnia wodna z wytrząsaniem.
  2. aparatura do pomiaru oddziaływania pomiędzy makrocząsteczkami BLItz.
  3. spektrometr dichroizmu kołowego z osprzętem (500 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Molecular chaperones involved in mitochondrial iron–sulfur protein biogenesis
    Authors:
    Rafal Dutkiewicz, Malgorzata Nowak
    Academic press:
    J Biol Inorg Chem (rok: 2017, tom: 1, strony: 45302), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00775-017-1504-x - link to the publication
  2. Biochemical Convergence of Mitochondrial Hsp70 System Specialized in Iron-Sulfur Cluster Biogenesis.
    Authors:
    Malgorzata Kleczewska, Aneta Grabinska, Marcin Jelen, Milena Stolarska, Brenda Schilke, Elizabeth A. Craig, Jaroslaw Marszalek, Rafal Dutkiewicz
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21093326 - link to the publication
  3. Fe–S Cluster Hsp70 Chaperones: The ATPase Cycle and Protein Interactions
    Authors:
    Rafal Dutkiewicz, Malgorzata Nowak, Elizabeth A. Craig, Jaroslaw Marszalek
    Academic press:
    Methods in Enzymology, (rok: 2017, tom: 595, strony: 161-184), Wydawca: ELSEVIER ACADEMIC PRESS INC
    Status:
    Published
    DOI:
    10.1016/bs.mie.2017.07.004 - link to the publication
  4. During FeS-cluster biogenesis ferredoxin and frataxin use overlapping binding sites on yeast cysteine desulfurase Nfs1
    Authors:
    Marta A. Uzarska, Igor Grochowina, Joanna Soldek, Marcin Jelen, Brenda Schilke, Jaroslaw Marszalek, Elizabeth A. Craig, Rafal Dutkiewicz
    Academic press:
    Journal of Biological Chemistry , Wydawca: Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology
    Status:
    Accepted for publication
    DOI:
    10.1016/ - link to the publication
  5. Iron insertion at the assembly site of the ISCU scaffold protein is a conserved process initiating Fe-S cluster biosynthesis
    Authors:
    Batoul Srour, Sylvain Gervason, Beata Monfort, Djabir Larkem, Nadine Trabelsi, Gautier Landrot, Andrea Zitolo, Emiliano Fonda, Emilien Etienne, Guillaume Gerbaud, Christina Sophia Müller, Maren Hellen Hoock, Jonathan Oltmanns, Jesse B. Gordon, Vishal Yadav, Malgorzata Kleczewska, Marcin Jelen, Michel Toledano, Rafal Dutkiewicz, David P. Goldberg, Volker Schünemann, Bruno Guigliarelli, Bénédicte Burlat, Christina Sizun, Benoit D'Autréaux
    Academic press:
    Journal of the American Chemical Society , Wydawca: ACS Publications
    Status:
    Submitted
    DOI:
    brak - link to the publication

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