Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Characterization of the TIM23 pathway of protein import into mitochondria in mammalian cells.

2015/19/B/NZ3/03272

Keywords:

mitochondria protein transport TIM23 translocases,

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Wasilewski 

Number of co-investigators in the project: 3

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 198 600 PLN

Project start date (Y-m-d): 2016-06-27

Project end date (Y-m-d): 2019-07-26

Project duration:: 37 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputery (2 szt.) (16 500 PLN)
  2. Miernik pH (6 000 PLN)
  3. Ekran do odczytu radioaktywości (12 400 PLN)
  4. Pompa próżniowa (6 500 PLN)
  5. Zamrażarka -20°C (3 000 PLN)
  6. zestawy do elektrotransferu (8 103 PLN)
  7. Zestaw do elektroforezy białek (2 600 PLN)
  8. Dodatkowe wyposażenie fluorescencyjne do mikroskopu świetlnego (23 500 PLN)
  9. Komora laminarna (50 500 PLN)
  10. mieszadła elektromagnetyczne (1 885 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. COA6 Facilitates Cytochrome c Oxidase Biogenesis as Thiolreductase for Copper Metallochaperones in Mitochondria
    Authors:
    Pacheu-Grau D., Wasilewski M., Oeljeklaus S., Silvia Gibhardt Ch, Aich A., Chudenkova M., Dennerlein S., Deckers M., Bogeski I., Warscheid B., Chacinska A., Rehling R.
    Academic press:
    Journal of Molecular Biology (rok: 2020, tom: 432 (7), strony: 2067-2079), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jmb.2020.01.036 - link to the publication
  2. Inhibition of proteasome rescues a pathogenic variant of respiratory chain assembly factor COA7
    Authors:
    Mohanraj K., Wasilewski M., Benincá C., Cysewski D., Poznanski J., Sakowska P., Bugajska Z., Deckers M., Dennerlein S., Fernandez-Vizarra E., Rehling P., Dadlez M., Zeviani M., Chacinska A.
    Academic press:
    EMBO Molecular Medicine (rok: 2019, tom: 11(5), strony: e9561), Wydawca: EMBO Press
    Status:
    Published
    DOI:
    10.15252/emmm.201809561. - link to the publication
  3. Protein trafficking at the crossroads to mitochondria.
    Authors:
    Wasilewski M, Chojnacka K, Chacinska A
    Academic press:
    Biochimica et biophysica acta - Molecular Cell Research (rok: 2017, tom: 1864, strony: 125-137), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.019 - link to the publication
  4. Mitochondrial Oxidative Stress Induces Rapid Intermembrane Space/Matrix Translocation of Apurinic/Apyrimidinic Endonuclease 1 Protein through TIM23 Complex.
    Authors:
    Barchiesi A., Bazzani V., Tolotto V., Elancheliyan P., Wasilewski M., Chacinska A., Vascotto C.
    Academic press:
    Journal of Molecular Biology (rok: 2020, tom: 432(24), strony: 166713), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jmb.2020.11.012 - link to the publication
  5. Mitochondrial protein biogenesis in the synapse is supported by local translation
    Authors:
    Kuzniewska B., Cysewski D., Wasilewski M., Sakowska P., Milek J., Kulinski TM., Winiarski M., Kozielewicz P., Knapska E., Dadlez M., Chacinska A., Dziembowski A., Dziembowska M.
    Academic press:
    EMBO Reports (rok: 2020, tom: 21(8), strony: e48882), Wydawca: EMBO Press
    Status:
    Published
    DOI:
    10.15252/embr.201948882 - link to the publication

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