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Blastomere Biopsy and the onset of Metabolic Syndrome: a risk assessment trial in the mouse model

2015/19/D/NZ4/03696

Keywords

Descriptors

  • NZ5_1: Etiologia chorób człowieka
  • NZ4_11: Metabolizm
  • NZ2_2: Genomika, transkryptomika i epigenomika

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Federica Zacchini

Number of co-investigators in the project: 3

Call

SONATA 10 – announced on 2015-09-15

Amount awarded
867 804 PLN
Project start date
2016-07-21
Project end date
2020-07-20
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Klatka metaboliczna dla Mysz (4 pcs). Cost: 22 000 PLN
  2. Inkubator CO2 wraz z reduktorami.
  3. Klatka metaboliczna dla Mysz.
  4. Komputer stacjonarny. Cost: 6 000 PLN
  5. Laptop lenovo.
  6. Multichannel Pipet.
  7. Multichannel Pipet. Cost: 6 000 PLN
  8. Obiektyw do mikroskopu odwroconego.
  9. Płyta grzejna.
  10. System do analizy ciśnienie krwi. Cost: 35 000 PLN
  11. System monitorowania glukozy. Cost: 5 400 PLN
  12. Waga.
  13. dysk przenośny.
  14. mikrokuźnia.
  15. stereomikroskop.
  16. stolik grzewczy do mikroskopu odwroconego.

Information in the final report

Publication in academic press/journals (5)

  1. Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation

    Authors:
    Federica Zacchini, Maria Florencia Heber, Roberta Arena, Natalia Radczuk , Urszula Jankowska, Grażyna Ewa Ptak
    Academic press:
    Theriogenology (year: 2021, volume: 171, pages: 119-129), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.theriogenology.2021.05.022. – link to the publication

  2. Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline

    Authors:
    Ramya Potabattula, Federica Zacchini, Grazyna Ewa Ptak , Marcus Dittrich , Tobias Müller , Nady El Hajj, Thomas Hahn , Charis Drummer, Rüdiger Behr, Andrea Lucas-Hahn, Heiner Niemann, Martin Schorsch , Thomas Haaf
    Academic press:
    Aging Cell (year: 2020, volume: -, pages: e13181), Publisher: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/acel.13181 – link to the publication

  3. Embryo Biopsy and development: the known and unknown

    Authors:
    Zacchini Federica, Arena Roberta, Adam Abramik, Ptak Grazyna Ewa
    Academic press:
    Reproduction (year: 2017, volume: 154 (5), pages: R143-R148), Publisher: Bioscientifica
    Status:
    Published
    DOI:
    10.1530/REP-17-0431 – link to the publication

  4. Assessing the epigenetic risks of assisted reproductive technologies: a way forward.

    Authors:
    Zacchini F, Sampino S, Stankiewicz AM, Haaf T, Ptak GE.
    Academic press:
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (year: 2019, volume: -, pages: 217-222), Publisher: 63
    Status:
    Published
    DOI:
    10.1387/ijdb.180402gp. – link to the publication

  5. Developmental peculiarities in placentae of ovine uniparental conceptuses

    Authors:
    Arena Roberta, Zacchini Federica, Toschi Paola, Palazzese Luca, Czernik Marta, Ptak Grazyna Ewa
    Academic press:
    Plos One (year: 2017, volume: 12 (11), pages: e0188278), Publisher: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0188278 – link to the publication

Articles in post-conference publications (4)

  1. Blastomere Biopsy as factor of risk for impaired fetal development in mouse model

    Authors:
    Zacchini F, Arena R, Abramik A, Ptak GE
    Conference:
    VIII Zjeździe Towarzystwa Biologii Rozrodu (year: 2017, pages: 120), Publisher: Towarzystwa Biologii Rozrodu
    Date:
    conference od 7/09 do 09/09
    Status:
    Published

  2. Blastomere Biopsy as factor of risk for the onset of metabolic disorders in adult mice

    Authors:
    Zacchini F, Gurgul A, Semik E, Pawlina K, Szmatoła T, Bugno-Poniewierska M, Ptak GE
    Conference:
    Fourth World Congress of Reproductive Biology (WCRB2017) (year: 2017, pages: P6-72), Publisher: WCRB
    Date:
    conference 27/09-29/09
    Status:
    Published

  3. Genome-wide methylation profile of placentae and fetal tissues developed following Assisted Reproductive Technologies

    Authors:
    Zacchini F, Stankiewicz AM, Bernhardt L, Haaf T, Ptak GE
    Conference:
    The 5th Winter Workshop of the Society for Biology of Reproduction (year: 2019, pages: 103), Publisher: TBR
    Date:
    conference 13-15 Febrauary
    Status:
    Published

  4. Post-natal growth and fertility offspring developed following embryonic diapause

    Authors:
    Zacchini F, Fic K, Polanski Z, Ptak GE
    Conference:
    Third International Symposium on Embryonic Diapause (year: 2019, pages: 51), Publisher: Third International Symposium on Embryonic Diapause
    Date:
    conference 2-6 June
    Status:
    Published

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