Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Blastomere Biopsy and the onset of Metabolic Syndrome: a risk assessment trial in the mouse model

2015/19/D/NZ4/03696

Keywords:

Blastomere Biopsy Metabolic Syndrome Mouse Model

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ4_11: Metabolism
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Federica Zacchini 

Number of co-investigators in the project: 3

Call: SONATA 10 - announced on 2015-09-15

Amount awarded: 867 804 PLN

Project start date (Y-m-d): 2016-07-21

Project end date (Y-m-d): 2020-07-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. dysk przenośny.
  2. Płyta grzejna.
  3. stereomikroskop.
  4. Klatka metaboliczna dla Mysz (4 szt.) (22 000 PLN)
  5. Inkubator CO2 wraz z reduktorami.
  6. Klatka metaboliczna dla Mysz.
  7. Komputer stacjonarny (6 000 PLN)
  8. Multichannel Pipet.
  9. Obiektyw do mikroskopu odwroconego.
  10. Waga.
  11. mikrokuźnia.
  12. System monitorowania glukozy (5 400 PLN)
  13. Laptop lenovo.
  14. Multichannel Pipet (6 000 PLN)
  15. System do analizy ciśnienie krwi (35 000 PLN)
  16. stolik grzewczy do mikroskopu odwroconego.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
    Authors:
    Ramya Potabattula, Federica Zacchini, Grazyna Ewa Ptak , Marcus Dittrich , Tobias Müller , Nady El Hajj, Thomas Hahn , Charis Drummer, Rüdiger Behr, Andrea Lucas-Hahn, Heiner Niemann, Martin Schorsch , Thomas Haaf
    Academic press:
    Aging Cell (rok: 2020, tom: -, strony: e13181), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/acel.13181 - link to the publication
  2. Developmental peculiarities in placentae of ovine uniparental conceptuses
    Authors:
    Arena Roberta, Zacchini Federica, Toschi Paola, Palazzese Luca, Czernik Marta, Ptak Grazyna Ewa
    Academic press:
    Plos One (rok: 2017, tom: 12 (11), strony: e0188278), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0188278 - link to the publication
  3. Embryo Biopsy and development: the known and unknown
    Authors:
    Zacchini Federica, Arena Roberta, Adam Abramik, Ptak Grazyna Ewa
    Academic press:
    Reproduction (rok: 2017, tom: 154 (5), strony: R143-R148), Wydawca: Bioscientifica
    Status:
    Published
    DOI:
    10.1530/REP-17-0431 - link to the publication
  4. Assessing the epigenetic risks of assisted reproductive technologies: a way forward.
    Authors:
    Zacchini F, Sampino S, Stankiewicz AM, Haaf T, Ptak GE.
    Academic press:
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (rok: 2019, tom: -, strony: 217-222), Wydawca: 63
    Status:
    Published
    DOI:
    10.1387/ijdb.180402gp. - link to the publication
  5. Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation
    Authors:
    Federica Zacchini, Maria Florencia Heber, Roberta Arena, Natalia Radczuk , Urszula Jankowska, Grażyna Ewa Ptak
    Academic press:
    Theriogenology (rok: 2021, tom: 171, strony: 119-129), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.theriogenology.2021.05.022. - link to the publication
  1. Genome-wide methylation profile of placentae and fetal tissues developed following Assisted Reproductive Technologies
    Authors:
    Zacchini F, Stankiewicz AM, Bernhardt L, Haaf T, Ptak GE
    Conference:
    The 5th Winter Workshop of the Society for Biology of Reproduction (rok: 2019, ), Wydawca: TBR
    Data:
    konferencja 13-15 Febrauary
    Status:
    Published
  2. Blastomere Biopsy as factor of risk for impaired fetal development in mouse model
    Authors:
    Zacchini F, Arena R, Abramik A, Ptak GE
    Conference:
    VIII Zjeździe Towarzystwa Biologii Rozrodu (rok: 2017, ), Wydawca: Towarzystwa Biologii Rozrodu
    Data:
    konferencja od 7/09 do 09/09
    Status:
    Published
  3. Blastomere Biopsy as factor of risk for the onset of metabolic disorders in adult mice
    Authors:
    Zacchini F, Gurgul A, Semik E, Pawlina K, Szmatoła T, Bugno-Poniewierska M, Ptak GE
    Conference:
    Fourth World Congress of Reproductive Biology (WCRB2017) (rok: 2017, ), Wydawca: WCRB
    Data:
    konferencja 27/09-29/09
    Status:
    Published
  4. Post-natal growth and fertility offspring developed following embryonic diapause
    Authors:
    Zacchini F, Fic K, Polanski Z, Ptak GE
    Conference:
    Third International Symposium on Embryonic Diapause (rok: 2019, ), Wydawca: Third International Symposium on Embryonic Diapause
    Data:
    konferencja 2-6 June
    Status:
    Published

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