Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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DExD/H-box RNA helicases in fish anti-viral immune response

2015/18/E/NZ6/00516

Keywords:

DExD/H-box RNA helicases DDX1 DDX3 DHX9 anti-viral immune response interferon common carp zebrafish SVCV

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_3: Animal immunology
  • NZ6_5: Virology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Krzysztof Rakus 

Number of co-investigators in the project: 3

Call: SONATA BIS 5 - announced on 2015-06-15

Amount awarded: 1 473 500 PLN

Project start date (Y-m-d): 2016-06-08

Project end date (Y-m-d): 2023-06-07

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator CO2 (44 000 PLN)
  2. licencja na oprogramowanie Office Professional 2016 firmy Microsoft (1 sztuka).
  3. Aparatura do mikroiniekcji: reduktor butlowy.
  4. Aparatura do mikroiniekcji (94 000 PLN)
  5. Komora laminarna klasy II (56 500 PLN)
  6. Aparatura do mikroiniekcji: Mikroskop stereoskopowy.
  7. Inkubator mikrobiologiczny.
  8. Wielodetekcyjny czytnik płytek (85 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Receptory rozpoznające wirusowe kwasy nukleinowe w odpowiedzi przeciwwirusowej ryb
    Authors:
    Krzysztof Rakus, Magdalena Chadzińska
    Academic press:
    Kosmos (rok: 2017, tom: 66, strony: 609-621), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
  2. Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior
    Authors:
    Mojzesz M., Widziolek M., Adamek M., Orzechowska U., Podlasz P., Prajsnar T.K., Pooranachandran N., Pecio A., Michalik A., Surachetpong W., Chadzinska M., Rakus K.
    Academic press:
    Frontiers in Immunology (rok: 2021, tom: 12, strony: 760882), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.760882 - link to the publication
  3. Type I interferon responses of common carp strains with different levels of resistance to koi herpesvirus disease during infection with CyHV-3 or SVCV
    Authors:
    Adamek M., Matras M., Dawson A., Piackova V., Gela D., Kocour M., Adamek J., Kaminski R., Rakus K., Bergmann S.M., Stachnik M., Reichert M., Steinhagen D.
    Academic press:
    Fish & Shellfish Immunology (rok: 2019, tom: 87, strony: 809-819), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fsi.2019.02.022 - link to the publication
  4. Evaluation of zebrafish (Danio rerio) as an animal model for the viral infections of fish
    Authors:
    Rakus K., Adamek M., Mojżesz M., Podlasz P., Chmielewska-Krzesińska M., Naumowicz K., Kasica-Jarosz N., Kłak K., Rakers S., Way K., Steinhagen D., Chadzińska M
    Academic press:
    Journal of Fish Diseases (rok: 2019, tom: 42, strony: 923-934), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jfd.12994 - link to the publication
  5. Jak infekcje i cytokiny wpływają na sen i zachowanie zwierząt?
    Authors:
    Rakus K., Chadzinska M
    Academic press:
    KOSMOS (rok: 2020, tom: 69, strony: 461-473), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
  6. Antiviral response of adult zebrafish (Danio rerio) during tilapia lake virus (TiLV) infection
    Authors:
    Rakus K., Mojzesz M., Widziolek M., Pooranachandran N., Teitge F., Surachetpong W., Chadzinska M., Steinhagen D., Adamek M.
    Academic press:
    Fish and Shellfish Immunology (rok: 2020, tom: 101, strony: 45299), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fsi.2020.03.040 - link to the publication
  7. Viral infection-induced changes in the expression profile of non-RLR DExD/H-box RNA helicases (DDX1, DDX3, DHX9, DDX21 and DHX36) in zebrafish and common carp
    Authors:
    Mojzesz M., Klak K., Wojtal P., Adamek M., Podlasz P., Chmielewska-Krzesinska M., Matras M., Reichert M., Chadzinska M., Rakus K.
    Academic press:
    Fish and Shellfish Immunology (rok: 2020, tom: 104, strony: 62-73), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fsi.2020.06.010 - link to the publication
  8. Acyclovir inhibits Cyprinid herpesvirus 3 multiplication in vitro.
    Authors:
    Troszok A., Kolek L., Szczygieł J., Wawrzeczko J., Borzym E., Reichert M., Kamińska T., Ostrowski T., Jurecka P., Adamek M., Rakus K., Irnazarow I.
    Academic press:
    Journal of Fish Diseases (rok: 2018, tom: 41, strony: 1709-1718), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jfd.12880 - link to the publication
  9. Cytosolic sensors for pathogenic viral and bacterial nucleic acids in fish
    Authors:
    Mojzesz M., Rakus K., Chadzinska M., Nakagami K., Biswas G., Sakai M., Hikima J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: E7289), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21197289 - link to the publication
  10. Type I interferon-dependent response of zebrafish larvae during tilapia lake virus (TiLV) infection
    Authors:
    Widziolek M., Janik K., Mojzesz M., Pooranachandran N., Adamek M., Pecio A., Surachetpong W., Levraud J.-P., Boudinot P., Chadzinska M., Rakus K.
    Academic press:
    Developmental and Comparative Immunology (rok: 2021, tom: 116, strony: 103936), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dci.2020.103936 - link to the publication