Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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DExD/H-box RNA helicases in fish anti-viral immune response

2015/18/E/NZ6/00516

Keywords:

DExD/H-box RNA helicases DDX1 DDX3 DHX9 anti-viral immune response interferon common carp zebrafish SVCV

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_3: Animal immunology
  • NZ6_5: Virology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Krzysztof Rakus 

Number of co-investigators in the project: 3

Call: SONATA BIS 5 - announced on 2015-06-15

Amount awarded: 1 473 500 PLN

Project start date (Y-m-d): 2016-06-08

Project end date (Y-m-d): 2023-06-07

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator CO2 (44 000 PLN)
  2. Komora laminarna klasy II (56 500 PLN)
  3. Wielodetekcyjny czytnik płytek (85 000 PLN)
  4. Inkubator mikrobiologiczny.
  5. licencja na oprogramowanie Office Professional 2016 firmy Microsoft (1 sztuka).
  6. Aparatura do mikroiniekcji: Mikroskop stereoskopowy.
  7. Aparatura do mikroiniekcji (94 000 PLN)
  8. Aparatura do mikroiniekcji: reduktor butlowy.

Information in the final report

  • Publication in academic press/journals (10)
  1. Acyclovir inhibits Cyprinid herpesvirus 3 multiplication in vitro.
    Authors:
    Troszok A., Kolek L., Szczygieł J., Wawrzeczko J., Borzym E., Reichert M., Kamińska T., Ostrowski T., Jurecka P., Adamek M., Rakus K., Irnazarow I.
    Academic press:
    Journal of Fish Diseases (rok: 2018, tom: 41, strony: 1709-1718), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jfd.12880 - link to the publication
  2. Jak infekcje i cytokiny wpływają na sen i zachowanie zwierząt?
    Authors:
    Rakus K., Chadzinska M
    Academic press:
    KOSMOS (rok: 2020, tom: 69, strony: 461-473), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
  3. Type I interferon responses of common carp strains with different levels of resistance to koi herpesvirus disease during infection with CyHV-3 or SVCV
    Authors:
    Adamek M., Matras M., Dawson A., Piackova V., Gela D., Kocour M., Adamek J., Kaminski R., Rakus K., Bergmann S.M., Stachnik M., Reichert M., Steinhagen D.
    Academic press:
    Fish & Shellfish Immunology (rok: 2019, tom: 87, strony: 809-819), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fsi.2019.02.022 - link to the publication
  4. Cytosolic sensors for pathogenic viral and bacterial nucleic acids in fish
    Authors:
    Mojzesz M., Rakus K., Chadzinska M., Nakagami K., Biswas G., Sakai M., Hikima J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: E7289), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21197289 - link to the publication
  5. Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior
    Authors:
    Mojzesz M., Widziolek M., Adamek M., Orzechowska U., Podlasz P., Prajsnar T.K., Pooranachandran N., Pecio A., Michalik A., Surachetpong W., Chadzinska M., Rakus K.
    Academic press:
    Frontiers in Immunology (rok: 2021, tom: 12, strony: 760882), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.760882 - link to the publication
  6. Antiviral response of adult zebrafish (Danio rerio) during tilapia lake virus (TiLV) infection
    Authors:
    Rakus K., Mojzesz M., Widziolek M., Pooranachandran N., Teitge F., Surachetpong W., Chadzinska M., Steinhagen D., Adamek M.
    Academic press:
    Fish and Shellfish Immunology (rok: 2020, tom: 101, strony: 45299), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fsi.2020.03.040 - link to the publication
  7. Receptory rozpoznające wirusowe kwasy nukleinowe w odpowiedzi przeciwwirusowej ryb
    Authors:
    Krzysztof Rakus, Magdalena Chadzińska
    Academic press:
    Kosmos (rok: 2017, tom: 66, strony: 609-621), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
  8. Viral infection-induced changes in the expression profile of non-RLR DExD/H-box RNA helicases (DDX1, DDX3, DHX9, DDX21 and DHX36) in zebrafish and common carp
    Authors:
    Mojzesz M., Klak K., Wojtal P., Adamek M., Podlasz P., Chmielewska-Krzesinska M., Matras M., Reichert M., Chadzinska M., Rakus K.
    Academic press:
    Fish and Shellfish Immunology (rok: 2020, tom: 104, strony: 62-73), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fsi.2020.06.010 - link to the publication
  9. Evaluation of zebrafish (Danio rerio) as an animal model for the viral infections of fish
    Authors:
    Rakus K., Adamek M., Mojżesz M., Podlasz P., Chmielewska-Krzesińska M., Naumowicz K., Kasica-Jarosz N., Kłak K., Rakers S., Way K., Steinhagen D., Chadzińska M
    Academic press:
    Journal of Fish Diseases (rok: 2019, tom: 42, strony: 923-934), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jfd.12994 - link to the publication
  10. Type I interferon-dependent response of zebrafish larvae during tilapia lake virus (TiLV) infection
    Authors:
    Widziolek M., Janik K., Mojzesz M., Pooranachandran N., Adamek M., Pecio A., Surachetpong W., Levraud J.-P., Boudinot P., Chadzinska M., Rakus K.
    Academic press:
    Developmental and Comparative Immunology (rok: 2021, tom: 116, strony: 103936), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dci.2020.103936 - link to the publication