Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New tools and applications of NMR spectroscopy beyond resolution limitation

2015/18/A/ST4/00270

Keywords:

NMR spectroscopy intrinsically disordered proteins large proteins folding-unfolding cross-corelated relaxation

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_13: Solid-state chemistry, surface physicochemistry
  • NZ1_3: Biophysics

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wiktor Koźmiński 

Number of co-investigators in the project: 11

Call: MAESTRO 7 - announced on 2015-06-15

Amount awarded: 3 252 000 PLN

Project start date (Y-m-d): 2016-05-13

Project end date (Y-m-d): 2023-05-12

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer stacjonarny. (5 szt.) (30 000 PLN)
  2. Chromatograf.
  3. Waga precyzyjna.
  4. Serwer obliczeniowy. (30 000 PLN)
  5. Zestaw do spektroskopii NMR pod wysokim ciśnieniem (330 000 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  1. 1H, 13C and 15N backbone resonance assignment of BRCA1 fragment 219–504
    Authors:
    Michał Górka, Szymon Żerko, Robert Konrat, Wiktor Koźmiński, Dennis Kurzbach
    Academic press:
    Biomolecular NMR Assignments (rok: 2020, tom: 14, strony: 289–293), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12104-020-09963-6 - link to the publication
  2. Coupled MD simulations and NMR reveal that the intrinsically disordered domain of the breast-cancer susceptibility 1 protein (BRCA1) binds head-on to DNA double-strand ends
    Authors:
    Kateryna Che, Thomas Kress, Michał Górka, Szymon Żerko, Wiktor Kozminski, Dennis Kurzbach
    Academic press:
    Journal of Magnetic Resonance Open (rok: 2022, tom: 45639, strony: 45297), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jmro.2022.100069 - link to the publication
  3. The Two Isoforms of Lyn Display Different Intramolecular Fuzzy Complexes with the SH3 Domain
    Authors:
    João M. C. Teixeira, Héctor Fuentes, Stase Bielskute, Margarida Gairi, Szymon Żerko, Wiktor Koźmiński and Miquel Pons
    Academic press:
    Molecules (rok: 2018, tom: 23, strony: 2731-2741), Wydawca: MDPI AG, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/molecules23112731 - link to the publication
  4. High-dimensional NMR methods for intrinsically disordered proteins studies
    Authors:
    Katarzyna Grudziąż, Anna Zawadzka-Kazimierczuk, Wiktor Koźmiński
    Academic press:
    Methods (rok: 2019, tom: 148, strony: 81-87), Wydawca: elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymeth.2018.04.031 - link to the publication
  5. Mechanism of Atg9 recruitment by Atg11 in the cytoplasm-to-vacuole targeting pathway
    Authors:
    Nicolas Coudevylle, Bartłomiej Banaś , Verena Baumann, Martina Schuschnig, Anna Zawadzka-Kazimierczuk, Wiktor Koźmiński, Sascha Martens
    Academic press:
    Journal of Biological Chemistry (rok: 2022, tom: 298, strony: 101573), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jbc.2022.101573 - link to the publication
  6. Hyperphosphorylation of Human Osteopontin and Its Impact on Structural Dynamics and Molecular Recognition
    Authors:
    B. Mateos, J. Holzinger, C. Conrad-Billroth, G. Platzer, S. Żerko, M. Sealey-Cardona, D. Anrather, W. Koźmiński, R. Konrat
    Academic press:
    Biochemistry (rok: 2021, tom: 60, strony: 1347−1355), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.biochem.1c00050 - link to the publication
  7. Order from disorder in the sarcomere: FATZ forms a fuzzy but tight complex and phase-separated condensates with α-actinin
    Authors:
    A. Sponga, J.L. Arolas, T.C. Schwarz, Cy M. Jeffries, A. Rodriguez Chamorro, J. Kostan, A. Ghisleni, F. Drepper, A. Polyansky, E. De Almeida Ribeiro, M. Pedron, A. Zawadzka-Kazimierczuk, G. Mlynek, T. Peterbauer, P. Doto, C. Schreiner, E. Holler, B. Mateos, L. Geist, G. Faulkner, W. Koźmiński, D. I. Svergun, B. Warscheid, B. Zagrović, M. Gautel, R. Konrat, K. Djinović-Carugo
    Academic press:
    Science Advances (rok: 2021, tom: 7, strony: 1), Wydawca: American Association for the Advancement of Science.
    Status:
    Published
    DOI:
    10.1126/sciadv.abg7653 - link to the publication
  8. Reconstruction of non-uniformly sampled five-dimensional NMR spectra by signal separation algorithm
    Authors:
    Krzysztof Kosiński, Jan Stanek, Michał J. Górka, Szymon Żerko, Wiktor Koźmiński
    Academic press:
    Journal of Biomolecular NMR (rok: 2017, tom: 68, strony: 129–138), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10858-017-0095-8 - link to the publication
  9. Structural analysis of 25-hydroxycholesterol stereoisomers differing in configuration in position 17 and 20, by three-dimensional NMR spectra
    Authors:
    MariaMisiak, WiktorKoźmiński, JacekWójcik, Rafał R.Siciński, Jerzy Wicha
    Academic press:
    Steroids (rok: 2019, tom: 143, strony: 49-52), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.steroids.2018.12.005 - link to the publication
  10. Structure and dynamics of Helicobacter pylori nickel-chaperone HypA: an integrated approach using NMR spectroscopy, functional assays and computational tools
    Authors:
    Chris A. E. M. Spronk, Szymon Żerko, Michał Górka, Wiktor Koźmiński, Benjamin Bardiaux, Barbara Zambelli, Francesco Musiani, Mario Piccioli, Priyanka Basak, Faith C. Blum, Ryan C. Johnson, Heidi Hu, D. Scott Merrell, Michael Maroney, Stefano Ciurli
    Academic press:
    Journal of Biological Inorganic Chemistry (rok: 2018, tom: 23, strony: 1309–1330), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00775-018-1616-y - link to the publication
  11. Structure, dynamics, and function of SrnR, a transcription factor for nickel-dependent gene expression
    Authors:
    L. Mazzei, F. Musiani, S. Żerko, W. Koźmiński, M. Cianci, Y. Beniamino, S. Ciurli, B. Zambelli
    Academic press:
    Metallomics (rok: 2021, tom: 13, strony: 1), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/mtomcs/mfab069 - link to the publication

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