Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanisms of HIF switch in human endothelium.

2015/18/E/NZ3/00687

Keywords:

HIF-1 HIF-2 HIF-3 micro-RNA angiogenesis

Descriptors:

  • NZ1_2: Biochemistry
  • NZ3_1: Cell biology
  • NZ1_1: Molecular biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Rafał Bartoszewski 

Number of co-investigators in the project: 5

Call: SONATA BIS 5 - announced on 2015-06-15

Amount awarded: 1 676 901 PLN

Project start date (Y-m-d): 2016-05-24

Project end date (Y-m-d): 2023-01-23

Project duration:: 80 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora typu glow box do badań (izolacji) komórek w warunkach hipoksji (możliwość jednoczesnej hodowli i pracy z komórkami) (135 693 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  1. EPAS1 resistance to miRNA-based regulation contributes to prolonged expression of HIF-2 during hypoxia in human endothelial cells
    Authors:
    Maciej Jaśkiewicz1*, Adrianna Moszyńska2, Magdalena Gebert3, James F. Collawn4 and Rafał Bartoszewski5*
    Academic press:
    Gene (rok: 2023, tom: 868, strony: 147376), Wydawca: elsevier
    Status:
    Published
    DOI:
    10.1016/j.gene.2023.147376 - link to the publication
  2. IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells
    Authors:
    Adrianna Moszyńska, James F. Collawn, Rafał Bartoszewski
    Academic press:
    Biomolecules (rok: 2020, tom: 10(6), strony: 895), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10060895 - link to the publication
  3. Primary Endothelial-specific Regulation of Hypoxia-inducible Factor (HIF)-1 and HIF-2 and their Target Gene Expression Profiles During Hypoxia
    Authors:
    Rafal Bartoszewski, Adrianna Moszyńska, Marcin Serocki, Aleksandra Cabaj, Andreas Polten, Renata Ochocka, Louis Dell'Italia, Sylwia Bartoszewska, Jarosław Króliczewski; Michał Dąbrowski and James F. Collawn
    Academic press:
    FASEB J (rok: 2019, tom: 33, strony: 7929-7941), Wydawca: FASEB
    Status:
    Published
    DOI:
    10.1096/fj.201802650RR - link to the publication
  4. miR-200b downregulates CFTR during hypoxia in human lung epithelial cells
    Authors:
    Sylwia Bartoszewska, Wojciech Kamysz, Bogdan Jakiela, Marek Sanak, Jarosław Króliczewski, Zsuzsa Bebok, Rafal Bartoszewski, James F Collawn
    Academic press:
    CMBL (rok: 2017, tom: 0,932638888888889, strony: 45305), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s11658-017-0054-0 - link to the publication
  5. The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
    Authors:
    Maciej Jaśkiewicz, Adrianna Moszyńska, Jarosław Króliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzyńska, Magda Gebert, Michał Dąbrowski, James F Collawn, Rafal Bartoszewski
    Academic press:
    Cellular & Molecular Biology Letters (rok: 2022, tom: 27, strony: 109), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s11658-022-00408-7 - link to the publication
  6. miR-200b downregulates Kruppel Like Factor 2 (KLF2) during acute hypoxia in human endothelial cells
    Authors:
    Rafal Bartoszewski MarcinSerocki AnnaJanaszak-Jasiecka SylwiaBartoszewska KingaKochan-Jamrozy ArkadiuszPiotrowski JarosławKróliczewski James F.Collawn
    Academic press:
    European Journal of Cell Biology (rok: 2017, tom: 96 (8), strony: 758-766), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.001 - link to the publication
  7. miRNAs regulate the HIF switch during hypoxia: a novel therapeutic target
    Authors:
    Marcin Serocki Sylwia Bartoszewska Anna Janaszak-Jasiecka Renata J. Ochocka James F. Collawn Rafał Bartoszewski
    Academic press:
    Angiogenesis (rok: 2018, tom: 21, strony: 183-202), Wydawca: Springer Netherlands
    Status:
    Published
    DOI:
    10.1007/s10456-018-9600-2 - link to the publication
  8. Hypoxia-inducible factor (HIF)-3a2 serves as an endothelial cell fate executor during chronic hypoxia
    Authors:
    Maciej Jaskiewicz, Adrianna Moszynska, Marcin Serocki, Jaroslaw Króliczewski, Sylwia Bartoszewska, James F Collawn, Rafal Bartoszewski
    Academic press:
    EXCLI journal (rok: 2022, tom: 21, strony: 454), Wydawca: EXCLI journal
    Status:
    Published
    DOI:
    10.17179/excli2021-4622 - link to the publication
  9. Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia
    Authors:
    Sylwia Bartoszewska, James Collawn
    Academic press:
    CMBL (rok: 2020, tom: 25, strony: 45311), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s11658-020-00212-1 - link to the publication
  10. The hypoxia-induced changes in miRNA-mRNA in RNA-induced silencing complexes and HIF-2 induced miRNAs in human endothelial cells
    Authors:
    Adrianna Moszyńska, Maciej Jaśkiewicz, Marcin Serocki, Aleksandra Cabaj, David K Crossman, Sylwia Bartoszewska, Magdalena Gebert, Michał Dąbrowski, James F Collawn, Rafal Bartoszewski
    Academic press:
    FASEB J (rok: 2022, tom: 36, strony: 7), Wydawca: Willey
    Status:
    Published
    DOI:
    10.1096/fj.202101987R - link to the publication
  11. Functional and HRE motifs count analysis of induction of selected hypoxia-responsive genes by HIF-1 and HIF-2 in human umbilical endothelial cells
    Authors:
    Aleksandra Cabaj, Adrianna Moszyńska, Agata Charzyńska, Rafał Bartoszewski, Michał Dąbrowski
    Academic press:
    Cellular signalling (rok: 2022, tom: 90, strony: 110209), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.cellsig.2021.110209 - link to the publication

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