Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Identification of novel therapies potentiating the efficacy of immunotherapy with anti-CD20 antibodies in in vivo models.

2015/18/E/NZ6/00702

Keywords:

CD20 monoclonal antibodies in vivo models

Descriptors:

  • NZ6_2: Clinical immunology
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Winiarska 

Number of co-investigators in the project: 6

Call: SONATA BIS 5 - announced on 2015-06-15

Amount awarded: 1 996 420 PLN

Project start date (Y-m-d): 2016-04-08

Project end date (Y-m-d): 2023-04-07

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Licencja FlowJo (2 szt.) (20 000 PLN)
  2. Cytometr przeplywowy 3-laserowy z podajnikiem (350 000 PLN)
  3. HTS podajnik do płytek do cytometru Canto (83 640 PLN)
  4. Licencja Graphpad/CDR.

Information in the final report

  • Publication in academic press/journals (4)
  1. CD37 in B Cell Derived Tumors—More than Just a Docking Point for Monoclonal Antibodies
    Authors:
    Malgorzata Bobrowicz, Matylda Kubacz, Aleksander Slusarczyk and Magdalena Winiarska
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21(24), strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21249531 - link to the publication
  2. FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy
    Authors:
    Pyrzynska B, Dwojak M, Zerrouqi A, Morlino G, Zapala P, Miazek N, Zagozdzon A, Bojarczuk K, Bobrowicz M, Siernicka M, Machnicki MM, Gobessi S, Barankiewicz J, Lech-Maranda E, Efremov DG, Juszczynski P, Calado D, Golab J, Winiarska M.
    Academic press:
    OncoImmunology (rok: 2018, tom: 7, strony: 1423183-1 - 1423183-9), Wydawca: Taylor and Francis Online
    Status:
    Published
    DOI:
    10.1080/2162402X.2017.1423183 - link to the publication
  3. HDAC6 inhibition up-regulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies
    Authors:
    Bobrowicz M, Dwojak M, Pyrzynska B, Stachura J, Muchowicz A, Berthel E, Dalla Venezia N, Kozikowski M, Siernicka M, Miazek N, Zapala P, Domagala A, Bojarczuk K, Malenda A, Barankiewicz J, Graczyk-Jarzynka A, Zagozdzon A, Gabrysiak M, Diaz JJ, Karp M, Lech-Maranda E, Firczuk M, Giannopoulos K, Efremov DG, Laurenti L, Baatout D, Frenzel L, Malinowska A, Slabicki M, Zenz T, Zerrouqi A, Golab J, Winiarska M.
    Academic press:
    Blood (rok: 2017, tom: 130(14), strony: 1628-1638), Wydawca: American Society of Hematology
    Status:
    Published
    DOI:
    10.1182/blood-2016-08-736066 - link to the publication
  4. Selective inhibition of HDAC6 sensitizes cutaneous T cell lymphoma cells to PI3K inhibitors
    Authors:
    Malgorzata Bobrowicz, Aleksander Slusarczyk, Joanna Stachura, Michal Dwojak, Desislava Ignatova, Yun-Tsan Chang, Christoph Iselin, Nina Miazek-Zapala, Katsiaryna Marhelava, Emmanuella Guenova, Magdalena Winiarska
    Academic press:
    Oncology Letters (rok: 2020, tom: 20(1), strony: 533-540), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ol.2020.11587 - link to the publication

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