Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Identification of genes and epigenetic events involved in human Th17 differentiation.

2015/18/E/NZ5/00733

Keywords:

Th17 lymphocytes epigenetics regulation of expression autoimmune disease

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_5: Diagnostics in human diseases
  • NZ2_6: Immunogenetics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Biologii Medycznej PAN

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Ratajewski 

Number of co-investigators in the project: 3

Call: SONATA BIS 5 - announced on 2015-06-15

Amount awarded: 1 105 400 PLN

Project start date (Y-m-d): 2016-05-13

Project end date (Y-m-d): 2021-05-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. 96 Real-Time PCR System (130 000 PLN)
  2. Wirówka laboratoryjna z chłodzeniem (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Functional Analysis of the rs774872314, rs116171003, rs200231898 and rs201107751 Polymorphisms in the Human RORγT Gene Promoter Region.
    Authors:
    Ratajewski M, Słomka M, Karaś K, Sobalska-Kwapis M, Korycka-Machała M, Sałkowska A, Dziadek J, Strapagiel D, Dastych J.
    Academic press:
    Genes (Basel) (rok: 2017, tom: 8(4), strony: E126), Wydawca: MDPI Open Access Journals
    Status:
    Published
    DOI:
    10.3390/genes8040126 - link to the publication
  2. Differentiation stage-specific effect of histone deacetylase inhibitors on the expression of RORγT in human lymphocytes.
    Authors:
    Sałkowska A, Karaś K, Walczak-Drzewiecka A, Dastych J, Ratajewski M.
    Academic press:
    Journal of Leukocyte Biology (rok: 2017, tom: 102(6), strony: 1487-1495), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1189/jlb.6A0617-217R - link to the publication
  3. Identification of Novel Molecular Markers of Human Th17 Cells.
    Authors:
    Sałkowska A, Karaś K, Karwaciak I, Walczak-Drzewiecka A, Krawczyk M, Sobalska-Kwapis M, Dastych J, Ratajewski M.
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1611), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9071611 - link to the publication
  4. SARS-CoV-2 Proteins Induce IFNG in Th1 Lymphocytes Generated from CD4+ Cells from Healthy, Unexposed Polish Donors
    Authors:
    Sałkowska A, Karwaciak I, Karaś K, Dastych J, Ratajewski M.
    Academic press:
    Vaccines (rok: 2020, tom: 8, strony: 673), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/vaccines8040673 - link to the publication
  5. Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages-Potential Implications for Cytokine Storm Syndrome
    Authors:
    Karwaciak I, Sałkowska A, Karaś K, Dastych J, Ratajewski M.
    Academic press:
    Vaccines (Basel). 2021 Jan 15;9(1):54. (rok: 2021, tom: 9(1), strony: 54), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/vaccines9010054 - link to the publication

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