Identification of genes and epigenetic events involved in human Th17 differentia

Identification of genes and epigenetic events involved in human Th17 differentiation.

2015/18/E/NZ5/00733

Keywords

Descriptors

NZ2_2: Genomika, transkryptomika i epigenomika
NZ5_5: Diagnostyka chorób człowieka
NZ2_6: Immunogenetyka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Instytut Biologii Medycznej PAN

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Marcin Marek Ratajewski

Number of co-investigators in the project: 3

Call

SONATA BIS 5 – announced on 2015-06-15

Amount awarded: 1 105 400 PLN
Project start date: 2016-05-13
Project end date: 2021-05-12
Project duration: 60 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

96 Real-Time PCR System. Cost: 130 000 PLN
Wirówka laboratoryjna z chłodzeniem. Cost: 25 000 PLN

Information in the final report

Publication in academic press/journals (5)

Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages-Potential Implications for Cytokine Storm Syndrome

Authors:
Karwaciak I, Sałkowska A, Karaś K, Dastych J, Ratajewski M.

Academic press:
Vaccines (Basel). 2021 Jan 15;9(1):54. (year: 2021, volume: 9(1), pages: 54), Publisher: MDPI

Status:
Published

DOI:
10.3390/vaccines9010054 – link to the publication
SARS-CoV-2 Proteins Induce IFNG in Th1 Lymphocytes Generated from CD4+ Cells from Healthy, Unexposed Polish Donors

Authors:
Sałkowska A, Karwaciak I, Karaś K, Dastych J, Ratajewski M.

Academic press:
Vaccines (year: 2020, volume: 8, pages: 673), Publisher: MDPI

Status:
Published

DOI:
10.3390/vaccines8040673 – link to the publication
Differentiation stage-specific effect of histone deacetylase inhibitors on the expression of RORγT in human lymphocytes.

Authors:
Sałkowska A, Karaś K, Walczak-Drzewiecka A, Dastych J, Ratajewski M.

Academic press:
Journal of Leukocyte Biology (year: 2017, volume: 102(6), pages: 1487-1495), Publisher: Wiley Online Library

Status:
Published

DOI:
10.1189/jlb.6A0617-217R – link to the publication
Functional Analysis of the rs774872314, rs116171003, rs200231898 and rs201107751 Polymorphisms in the Human RORγT Gene Promoter Region.

Authors:
Ratajewski M, Słomka M, Karaś K, Sobalska-Kwapis M, Korycka-Machała M, Sałkowska A, Dziadek J, Strapagiel D, Dastych J.

Academic press:
Genes (Basel) (year: 2017, volume: 8(4), pages: E126), Publisher: MDPI Open Access Journals

Status:
Published

DOI:
10.3390/genes8040126 – link to the publication
Identification of Novel Molecular Markers of Human Th17 Cells.

Authors:
Sałkowska A, Karaś K, Karwaciak I, Walczak-Drzewiecka A, Krawczyk M, Sobalska-Kwapis M, Dastych J, Ratajewski M.

Academic press:
Cells (year: 2020, volume: 9, pages: 1611), Publisher: MDPI

Status:
Published

DOI:
10.3390/cells9071611 – link to the publication

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