Possible significance of blood platelet COX-1 glycation and ubiquitination in understaniding of the molecular background of 'aspirin resistance' in patients with type 2 diabetes.
2015/17/N/NZ5/02605
Keywords
Descriptors
- NZ5_1: Etiologia chorób człowieka
- NZ5_3: Patogeneza chorób człowieka
- NZ5_7: Leczenie chorób człowieka
Panel
NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution
Uniwersytet Medyczny w Łodzi
Voivodeship: łódzkie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 9 – announced on 2015-03-16
- Amount awarded
- 95 510 PLN
- Project start date
- 2016-03-15
- Project end date
- 2019-03-14
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (1)
-
Non-enzymatic modifications of prostaglandin H synthase 1 affect bifunctional enzyme activity - Implications for the sensitivity of blood platelets to acetylsalicylic acid.
- Authors:
- Hassan Kassassir, Karolina Siewiera, Marcin Talar, Emilia Stec-Martyna, Zofia Pawlowska, Cezary Watala
- Academic press:
- Chemico-Biological Interactions (year: 2016, volume: 253, pages: 78-92), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.cbi.2016.04.021 – link to the publication
Articles in post-conference publications (2)
-
Parameters of blood morphology and platelet activation undergo changes during streptozotocin-induced diabetes in rats.
- Authors:
- Karolina Siewiera, Hassan Kassassir, Tomasz Przygodzki, Dawid Polak, Nina Wolska, Marcin Talar, Cezary Watala
- Conference:
- 25th Kraków Conference on Endothelium (year: 2017, pages: 1-118), Publisher: Jagiellonian Centre for Experimental Therapeutics
- Date:
- conference 20-21 października 2017 roku
- Status:
- Published
-
Prostaglandin H synthase 1 undergoes non-enzymatic N-glycosylation in platelets fromdiabetic rats
- Authors:
- Hassan Kassassir, Karolina Siewiera, Emilia Stec-Martyna, Zofia Pawlowska, Cezary Watala
- Conference:
- 1st Italian-UK Platelet Meeting University of Bath (year: 2017, pages: 735-761), Publisher: Platelets
- Date:
- conference 7-8 września 2017 roku
- Status:
- Published