Projects funded by the NCN
Possible significance of blood platelet COX-1 glycation and ubiquitination in understaniding of the molecular background of 'aspirin resistance' in patients with type 2 diabetes.
2015/17/N/NZ5/02605
Keywords:
non-enzymatic glycation COX-1 protein ubiquitination aspirin resistance blood platelet activation diabetes
Descriptors:
- NZ5_1: Etiology of human diseases
- NZ5_3: Pathogenesis of human diseases
- NZ5_7: Human disease treatment
Panel:
NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution :
Uniwersytet Medyczny w Łodzi
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 9 - announced on 2015-03-16
Amount awarded: 95 510 PLN
Project start date (Y-m-d): 2016-03-15
Project end date (Y-m-d): 2019-03-14
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Articles in post-conference publications (2)
- Non-enzymatic modifications of prostaglandin H synthase 1 affect bifunctional enzyme activity - Implications for the sensitivity of blood platelets to acetylsalicylic acid.Authors:Hassan Kassassir, Karolina Siewiera, Marcin Talar, Emilia Stec-Martyna, Zofia Pawlowska, Cezary WatalaAcademic press:Chemico-Biological Interactions (rok: 2016, tom: 253, strony: 78-92), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.cbi.2016.04.021 - link to the publication
- Parameters of blood morphology and platelet activation undergo changes during streptozotocin-induced diabetes in rats.Authors:Karolina Siewiera, Hassan Kassassir, Tomasz Przygodzki, Dawid Polak, Nina Wolska, Marcin Talar, Cezary WatalaConference:25th Kraków Conference on Endothelium (rok: 2017, ), Wydawca: Jagiellonian Centre for Experimental TherapeuticsData:konferencja 20-21 października 2017 rokuStatus:Published
- Prostaglandin H synthase 1 undergoes non-enzymatic N-glycosylation in platelets fromdiabetic ratsAuthors:Hassan Kassassir, Karolina Siewiera, Emilia Stec-Martyna, Zofia Pawlowska, Cezary WatalaConference:1st Italian-UK Platelet Meeting University of Bath (rok: 2017, ), Wydawca: PlateletsData:konferencja 7-8 września 2017 rokuStatus:Published