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Changes in the functioning of mitochondria as a potential factor promoting the procoagulant activity of blood platelets in diabetes

2015/17/N/NZ5/02603

Keywords:

blood platelets blood platelet activation mitochondria bioenergetics diabetes

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Karolina Siewiera 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 99 600 PLN

Project start date (Y-m-d): 2016-03-15

Project end date (Y-m-d): 2019-03-14

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (5)
  1. Sample Preparation as a Critical Aspect of Blood Platelet Mitochondrial Respiration Measurements-The Impact of Platelet Activation on Mitochondrial Respiration.
    Authors:
    Siewiera, K.; Labieniec-Watala, M.; Wolska, N.; Kassassir, H.; Watala, C.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: n/a (wydanie online)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22179332 - link to the publication
  2. Potential Role of Mitochondria as Modulators of Blood Platelet Activation and Reactivity in Diabetes. Effect of Metformin on Blood Platelet Bioenergetics and Platelet Activation
    Authors:
    Siewiera, K.; Labieniec-Watala, M.; Kassassir, H.; Wolska, N.; Watala, C.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: nieznany, strony: n/a (wydanie online)), Wydawca: MDPI
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Parameters of blood morphology and platelet activation undergo changes during streptozotocin-induced diabetes in rats.
    Authors:
    Karolina Siewiera, Hassan Kassassir, Tomasz Przygodzki, Dawid Polak, Nina Wolska, Marcin Talar, Cezary Watala
    Conference:
    25th Kraków Conference on Endothelium (rok: 2017, ), Wydawca: Jagiellonian Centre for Experimental Therapeutics
    Data:
    konferencja 20-21 października 2017 roku
    Status:
    Published
  2. Altered blood platelet reactivity is not related to elevated mitochondrial respiration in rat model of streptozotocin-induced diabetes
    Authors:
    Karolina Siewiera, Magdalena Labieniec-Watala, Hassan Kassassir, Dawid Polak, Nina Wolska, Cezary Watala
    Conference:
    1st Italian-UK Platelet Meeting University of Bath (rok: 2017, ), Wydawca: Platelets
    Data:
    konferencja 7-8 września 2017 roku
    Status:
    Published
  3. Changes in blood platelet and brain mitochondrial respiration during short and longlasting STZ-induced diabetes
    Authors:
    Siewiera K, Labieniec-Watala M, Karolczak K,Wolska N, Polak D, Kassassir H, Watala C
    Conference:
    12th Conference on Mitochondrial Physiology The role of mitochondria in lifestyle and metabolic syndrome (rok: 2017, ), Wydawca: Mitochondrial Physiology Society (2017-11-15) MitoGlobal
    Data:
    konferencja 15-18 listopada 2017
    Status:
    Published
    DOI:
    link to the publication
  4. The effect of metformin on blood platelet bioenergetics and platelet function.
    Authors:
    Siewiera K, Hertel J, Labieniec-Watala M, Kassassir H, Watala C
    Conference:
    Mitochondrial fitness mapping: Conference, Working Groups and MC meeting - COST Action MITOEAGLE (rok: 2017, ), Wydawca: Bioblast, MITOEAGLE
    Data:
    konferencja 21-23 marzec 2017
    Status:
    Published
    DOI:
    link to the publication
  5. Blood platelets as bioenergetic markers of brain damage in STZ-diabetes
    Authors:
    Siewiera K, Labieniec-Watala M, Wolska N, Polak D, Kassassir H, Watala C
    Conference:
    10th MiPschool 2017 (rok: 2017, ), Wydawca: Bioblast, MITOEAGLE
    Data:
    konferencja 23-30 lipca 2017
    Status:
    Published
    DOI:
    link to the publication

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