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The role of epigenetic changes and p53 in visceral adipose tissue in the pathogenesis of type 2 diabetes mellitus

2015/17/B/NZ7/03019

Keywords

Descriptors

  • NZ7_12: Prewencja chorób człowieka

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Medyczny w Łodzi, Katedra Biochemii Medycznej

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Janusz Zbigniew Szemraj

Number of co-investigators in the project: 8

Call

OPUS 9 – announced on 2015-03-16

Amount awarded
798 600 PLN
Project start date
2016-03-09
Project end date
2020-03-08
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (7)

  1. Is p53 Involved in Tissue-Specific Insulin Resistance Formation?

    Authors:
    Justyna Strycharz, Jozef Drzewoski, Janusz Szemraj, Agnieszka Sliwinska
    Academic press:
    Oxidative Medicine and Cellular Longevity (year: 2017, volume: -, pages: -), Publisher: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2017/9270549 – link to the publication

  2. Visceral Adipose Tissue of Prediabetic and Diabetic Females Shares a Set of Similarly Upregulated microRNAs Functionally Annotated to Inflammation, Oxidative Stress and Insulin Signaling.

    Authors:
    52.Strycharz J, Wróblewski A, Zieleniak A, Świderska E, Matyjas T, Rucińska M, Pomorski L, Czarny P, Szemraj J, Drzewoski J, Śliwińska A.
    Academic press:
    Antioxidants (Basel) (year: 2021, volume: 10, pages: 101), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox10010101 – link to the publication

  3. Chronic and Transient Hyperglycemia Induces Changes in the Expression Patterns of IL6 and ADIPOQ Genes and Their Associated Epigenetic Modifications in Differentiating Human Visceral Adipocytes

    Authors:
    Wróblewski, A.; Strycharz, J.; Świderska, E.; Balcerczyk, A.; Szemraj, J.; Drzewoski, J.; Śliwińska, A.
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 6964), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22136964 – link to the publication

  4. Hyperglycemia Changes Expression of Key Adipogenesis Markers (C/EBPα and PPARᵞ)and Morphology of Differentiating Human Visceral Adipocytes.

    Authors:
    Świderska E, Podolska M, Strycharz J, Szwed M, Abramczyk H, Brożek-Płuska B, Wróblewski A, Szemraj J, Majsterek I, Drzewoski J, Śliwińska A.
    Academic press:
    Nutrients (year: 2019, volume: 11, pages: 46039), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/nu11081835 – link to the publication

  5. MicroRNAs and metabolic disorders - where are we heading?

    Authors:
    Sliwinska A, Kasinska MA, Drzewoski J.
    Academic press:
    Archives of Medical Science (year: 2017, volume: 13, pages: 885-896), Publisher: Termedia
    Status:
    Published
    DOI:
    10.5114/aoms.2017.65229 – link to the publication

  6. Hyperglycemia Affects miRNAs Expression Pattern during Adipogenesis of Human Visceral Adipocytes-Is Memorization Involved?

    Authors:
    Strycharz J, Świderska E, Wróblewski A, Podolska M, Czarny P, Szemraj J, Balcerczyk A, Drzewoski J, Kasznicki J, Śliwińska A.
    Academic press:
    Nutrients (year: 2018, volume: 10, pages: 46041), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/nu10111774 – link to the publication

  7. Chronic and Intermittent Hyperglycemia Modulates Expression of Key Molecules of PI3K/AKT Pathway in Differentiating Human Visceral Adipocytes

    Authors:
    Świderska E, Strycharz J, Wróblewski A, Czarny P, Szemraj J, Drzewoski J, Śliwińska A.
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 7712), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22147712 – link to the publication

Articles in post-conference publications (8)

  1. HIPERGLIKEMIA ZABURZA EKSPRESJĘ miR-140-5p, miR-151a-5p I miR-193b-3p – CZĄSTECZEK O ZASADNICZYM ZNACZENIU DLA RÓŻNICOWANIA WISCERALNYCH KOMÓREK TŁUSZCZOWYCH

    Authors:
    Adam Wróblewski, Justyna Strycharz, Ewa Świderska, Marta Podolska, Piotr Czarny, Janusz Szemraj, Józef Drzewoski, Agnieszka Śliwińska
    Conference:
    XXZjazd Naukowy Polskiego Towarzystwa Diabetologicznego (year: 2019, pages: 12), Publisher: Via Medica
    Date:
    conference 16-18 maja
    Status:
    Published

  2. Hyperglycemia induces expression changes of miR-26a-5p and its target, IL6 gene, during the differentiation of visceral adipocytes

    Authors:
    Adam Wróblewski , Justyna Strycharz , Ewa Świderska , Janusz Szemraj , Józef Drzewoski, Agnieszka Śliwińska
    Conference:
    International Young Scientists Conference on Molecular and Cell Biology 2021 (year: 2021, pages: 106), Publisher: International Institute of Molecular and Cell Biology in Warsaw
    Date:
    conference 5-6 lutego
    Status:
    Published

  3. Diabetes and prediabetes similarly affect expression of miR-708-5p, miR-10a-5p and miR-99a-5p

    Authors:
    Adam Wróblewski, Justyna Strycharz, Ewa Świderska, Andrzej Zieleniak, Tomasz Matyjas, Monika Rucińska, Paweł Kumoniewski, Lech Pomorski, Katarzyna Białek, Janusz Szemraj, Józef Drzewoski, Agnieszka śliwińska
    Conference:
    From molecules to living systems. The 44th FEBS Congress (year: 2019, pages: -), Publisher: FEBS, PTBioch
    Date:
    conference 6-11 July
    Status:
    Published

  4. hiperglikemia zmienia profil ekspresji microRNA podczas adipogenezy wisceralnej

    Authors:
    Justyna, Strycharz, Ewa Świderska, Adam Wróblewski, Marta Podolska, Marzena Szwed, Piotr Czarny, Janusz Szemraj, Józef Drzewoski, Jacek Kasznicki, Agnieszka Sliwińska
    Conference:
    XX Zjazd Naukowy Polskiego Towarzystwa Diabetologicznego (year: 2019, pages: 13), Publisher: Via Medica
    Date:
    conference 16-18 maja
    Status:
    Published

  5. Przejściowa i chroniczna hiperglikemia zmienia profil globalnej metylacji DNA oraz acetylacji i trimetylacji histonu H3 w wisceralnych adipocytach

    Authors:
    Agnieszka Śliwińska, Aneta Balcerczyk, Ewa Świderska, Justyna Strycharz, Martyna Wojtala, Janusz Szemraj, Jacek Kasznicki, Józef Drzewoski
    Conference:
    XX Zjazd Naukowy Polskiego Towarzystwa Diabetologicznego (year: 2019, pages: 11), Publisher: Via Medica
    Date:
    conference 16-18 maja
    Status:
    Published

  6. Wpływ hiperglikemii na ekspresję miR-214, miR-20a, miR-21 oraz miR-26b w wisceralnych dojrzałych i niedojrzałych adipocytach

    Authors:
    Justyna Strycharz, Janusz Szemraj, Józef Drzewoski
    Conference:
    VI Konferencja Biologii Molekularnej (year: 2017, pages: 39), Publisher: Wydawnictwo Uniwersytetu Łódzkiego
    Date:
    conference 6.04-8.04
    Status:
    Published

  7. Wpływ hiperglikemii na poziom modulację ekspresji transportera glukozy GLUT4 w czasie różnicowania in vitro wisceralnych ludzkich adipocytów: potencjalna rola cząsteczek miRNA

    Authors:
    Ewa Świderska, Justyna Strycharz, Adam Wróblewski, Marta Podolska, Marzena Szwed, Janusz Szemraj, Józef Drzewoski, Agnieszka Śliwińska
    Conference:
    XX Zjazd Naukowy Polskiego Towarzystwa Diabetologicznego (year: 2019, pages: 12), Publisher: Via Medica
    Date:
    conference 16-19 maja
    Status:
    Published

  8. Hyperglycaemia changes the miRNA expression pattern during differentiation and maturation of human visceral adipocytes

    Authors:
    J. Strycharz, E. Swiderska, A. Wroblewski, M. Podolska, J. Drzewoski, J. Szemraj, A. Sliwinska;
    Conference:
    54th Annual Meeting of the European Association for the Study of Diabetes (year: 2018, pages: 334), Publisher: Springer
    Date:
    conference 1-5. 10.
    Status:
    Published

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