Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Recognition of genes associated with H3K4me3 histone protein responsible for polarization of neutrophils into suppressor cells during refractory inflammatory diseases

2015/17/B/NZ6/04251

Keywords:

neutrophils inflammation innate immunity

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_2: Clinical immunology
  • NZ3_3: Apoptosis

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Przemysław Lewkowicz 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 018 800 PLN

Project start date (Y-m-d): 2016-03-01

Project end date (Y-m-d): 2021-02-28

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do dezitegracji chromatyny - Bioruptor pico firmy DIAGENODE.
  2. aprat do elktroforezy białek wraz z zasilaczem i systemen do transferu (western blot) (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. C5a-Preactivated Neutrophils Are Critical for Autoimmune-Induced Astrocyte Dysregulation in Neuromyelitis Optica Spectrum Disorder.
    Authors:
    Piatek P, Domowicz M, Lewkowicz N, Przygodzka P, Matysiak M, Dzitko K and Lewkowicz P.
    Academic press:
    Frontiers in Immunology (rok: 2018, tom: volume 9, strony: 1694-1710), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.01694 - link to the publication
  2. H3K4me3 histone ChIPseq Analysis Reveals Molecular Mechanisms Responsible for Neutrophil dysfunction in HIV-infected individuals
    Authors:
    Paweł Piatek, Maciej Tarkowski, Magdalena Namiecinska, Agostino Riva, Marek Wieczorek, Sylwia Michlewska, Justyna Dulska, Małgorzata Domowicz, Małgorzata Kulińska-Michalska, Natalia Lewkowicz and Przemysław Lewkowicz
    Academic press:
    Frontiers in Immunology (rok: 2021, tom: VOL 12: 682094, strony: 2021 Jul 15;12:682094), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.682094 - link to the publication
  3. Changes within H3K4me3-marked histone reveal molecular background of neutrophil functional plasticity
    Authors:
    Paweł Piatek, Magdalena Namiecinska, Natalia Lewkowicz, Małgorzata Kulińska-Michalska, Zbigniew Jabłonowski, Mariola Matysiak, Justyna Dulska, Sylwia Michlewska, Marek Wieczorek, and Przemysław Lewkowicz
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: Vol.13 June 2022 Article 90631, strony: Article 906311 1-20), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.906311 - link to the publication

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