Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The effect of hypoxia on capability of mast cells to enhance proinflammatory activity of Th17 lymphocytes

2015/17/B/NZ6/04252

Keywords:

mast cells Th17 hypoxia

Descriptors:

  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Instytut Biologii Medycznej PAN

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jarosław Dastych 

Number of co-investigators in the project: 4

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 653 076 PLN

Project start date (Y-m-d): 2016-02-25

Project end date (Y-m-d): 2020-02-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora beztlenowa z analizatorem gazów i filtrami HEPA (90 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway
    Authors:
    Joanna Pastwińska, Aurelia Walczak-Drzewiecka, Magdalena Łukasiak, Marcin Ratajewski & Jarosław Dastych
    Academic press:
    Cell Adhesion & Migration (rok: 2020, tom: 14, strony: 106-117), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/19336918.2020.1764690 - link to the publication
  2. Hypoxia modulates human mast cell adhesion to hyaluronic acid
    Authors:
    Pastwińska J, Walczak-Drzewiecka A, Kozłowska E, Harunari E, Ratajewski M, Dastych J.
    Academic press:
    Immunologic Research (rok: 2022, tom: 70, strony: 152-160), Wydawca: HUMANA PRESS INC
    Status:
    Published
    DOI:
    10.1007/s12026-021-09228-x. - link to the publication
  3. The Art of Mast Cell Adhesion
    Authors:
    Pastwińska J, Żelechowska P, Walczak-Drzewiecka A, Brzezińska-Błaszczyk E, Dastych J.
    Academic press:
    Cells (rok: 2020, tom: 9, strony: Article Number 2664), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9122664 - link to the publication
  4. Mast cells as the strength of the inflammatory process.
    Authors:
    Pastwińska J, Agier J, Dastych J, Brzezińska-Błaszczyk E.
    Academic press:
    Polish Journal of Pathology (rok: 2017, tom: 68, strony: 187-196), Wydawca: VESALIUS UNIV MEDICAL PUBL
    Status:
    Published
    DOI:
    10.5114/pjp.2017.71526 - link to the publication

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