Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular mechanism of tumorigenic transformation of adrenocortical stem/progenitor cells.

2015/17/B/NZ5/00636

Keywords:

Adrenal gland GATA-4 LHCGR LH tumor stem cells mouse

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_1: Etiology of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Nafis Rahman 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 416 450 PLN

Project start date (Y-m-d): 2016-02-03

Project end date (Y-m-d): 2020-02-02

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Jednostka do znieczulania wziewnego U-410 ze strzykawką, przewodami doprowadzajacymi i pompą powietrzną. (25 500 PLN)
  2. Platforma do wizualizacji i dokumentacji żeli agarozowych, polakrylamidowych i membran PVD ChemiDoc™ MP System Bio-rad (120 000 PLN)
  3. Regał na 72 klatki 1285L z klatkami dla myszy i akcesoriami (butelki, kapsle, łaczniki regałów, tabliczka opisowa) wraz z jednostką wyciągowo-nawiewczą z ekranem dotykowym - 220/240V 50/60Hz, wyposażoną we wtyczkę Schuko (111 350 PLN)
  4. 2 komputery przenośny wraz z oprogramowaniem MS Office.
  5. Termocykler nexus gradient Eppendorf do reakcji PCR (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. GnRH antagonist treatment of malignant adrenocortical tumors
    Authors:
    Milena Doroszko, Marcin Chrusciel, Joanna Stelmaszewska, Tomasz Slezak, Slawomir Anisimowicz, Ursula Plöckinger, Marcus Quinkler, Marco Bonomi, Slawomir Wolczynski, Ilpo Huhtaniemi, Jorma Toppari, Nafis A Rahman
    Academic press:
    Endocrine-Related Cancer (rok: 2019, tom: 1,08402777777778, strony: 103–117), Wydawca: BioScientifica
    Status:
    Published
    DOI:
    10.1530/ERC-17-0399 - link to the publication
  2. Mouse models of adrenal tumors responsive to gonadotropin- releasing hormone and gonadotropins
    Authors:
    Kamila Pulawska, Milena Doroszko, Marcin Chrusciel, Donata Ponikwicka-Tyszko, Slawomir Wolczynski, Jorma Toppari, Ilpo Huhtaniemi, Nafis A. Rahman
    Academic press:
    Current Opinion in Endocrine and Metabolic Research (rok: 2019, tom: 8, strony: 189-194), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.coemr.2019.08.014 - link to the publication
  3. Novel genes involved in pathophysiology of gonadotropin-dependent adrenal tumors in mice
    Authors:
    Doroszko M, Chrusciel M, Belling K, Vuorenoja S, Dalgaard M, Leffers H, Nielsen HB, Huhtaniemi I, Toppari J, Rahman NA
    Academic press:
    Mol Cell Endocrinol. (rok: 2017, tom: 444:9-18, strony: 45553), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.mce.2017.01.036 - link to the publication
  4. Luteinizing Hormone and GATA4 Action in the Adrenocortical Tumorigenesis of Gonadectomized Female Mice
    Authors:
    Doroszko M.a · Chrusciel M.a · Stelmaszewska J.b · Slezak T.c · Rivero-Muller A.d,e · Padzik A.d · Anisimowicz S.f · Wolczynski S.b · Huhtaniemi I.a,g · Toppari J.a,h · Rahman N.A.
    Academic press:
    Cell Physiol Biochem (rok: 2017, tom: 43(3);1064-1076, strony: 1064-1076), Wydawca: KARGER
    Status:
    Published
    DOI:
    10.1159/000481718 - link to the publication