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Identification of biomarkers of individual radiochemotherapy toxicity and efficacy in patients with head and neck cancer based on a model combining clinical patient data and metabolomic blood profiling with NMR and MS.

2015/17/B/NZ5/01387

Keywords

Descriptors

  • NZ2_4: Metabolomika
  • NZ5_7: Leczenie chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

Voivodeship: śląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Krzysztof Składowski

Number of co-investigators in the project: 13

Call

OPUS 9 – announced on 2015-03-16

Amount awarded
1 071 800 PLN
Project start date
2016-01-27
Project end date
2021-01-26
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dewar na ciekły azot o pojemności 120 litrów (z systemem kontroli ciśnienia). Cost: 18 080 PLN
  2. Licencja oprogramowania SimLipid.
  3. Pakiet oprogramowania SpectrumMill..
  4. Przedłużenie licencji na oprogramowanie SIMCA-P.. Cost: 20 000 PLN
  5. Zamrażarka niskotemperaturowa (-86 stopni Celsiusa) z akcesoriami. (2 pcs). Cost: 184 000 PLN

Information in the final report

Publication in academic press/journals (11)

  1. 1H NMR based metabolomic approach to monitoring of the head and neck cancer treatment toxicity

    Authors:
    Łukasz Boguszewicz, Agata Hajduk, Jolanta Mrochem-Kwarciak, Agnieszka Skorupa, Mateusz Ciszek, Alicja Heyda, Krzysztof Składowski, Maria Sokół
    Academic press:
    Metabolomics (year: 2016, volume: 12(6), pages: 46037), Publisher: Springer US
    Status:
    Published
    DOI:
    10.1007/s11306-016-1043-4 – link to the publication

  2. Główne zmiany proteomu i metabolomu surowicy obserwowane w krwi osób poddanych radioterapii dotyczą wskaźników stanu zapalnego i odpowiedzi immunologicznej odzwierciedlających systemową toksyczność promieniowania jonizującego

    Authors:
    Karol Jelonek, Monika Pietrowska, Piotr Widłak
    Academic press:
    Onkologia i radioterapia (year: 2016, volume: 3, pages: 24-29), Publisher: Wydawnictwo SALVE / itMedical Team Sp.z o. o.
    Status:
    Published

  3. Ionizing radiation affects profile of serum metabolites: increased level of 3-hydroxybutyric acid in serum of cancer patients treated with radiotherapy

    Authors:
    Małgorzata Roś-Mazurczyk, Anna Wojakowska, Łukasz Marczak, Krzysztof Polański, Monika Pietrowska, Karol Jelonek, Iwona Domińczyk, Agata Hajduk, Tomasz Rutkowski, Krzysztof Składowski, Piotr Widłak
    Academic press:
    Acta Biochimica Polonica (year: 2016, volume: 63, pages: 46027), Publisher: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    10.18388/abp.2016_1301 – link to the publication

  4. NMR-Based Metabolomics in Investigation of the Radiation Induced Changes in Blood Serum of Head and Neck Cancer Patients and Its Correlation with the Tissue Volumes Exposed to the Particulate Doses

    Authors:
    Łukasz Boguszewicz, Agata Bieleń, Mateusz Ciszek, Jacek Wendykier, Krzysztof Szczepanik, Agnieszka Skorupa, Jolanta Mrochem-Kwarciak, Krzysztof Składowski, Maria Sokół
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22(12), pages: 6310), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126310 – link to the publication

  5. Radiotherapy-induced changes in serum lipid profile of patients with prostate or head and neck cancer

    Authors:
    Malgorzata Roś-Mazurczyk, Karol Jelonek, Monika Pietrowska, Adam Zagdański, Agnieszka Suchwałko, Tomasz Jastrząb, Joanna Polańska, Ewa Chawińska, Wojciech Majewski, Iwona Domińczyk, Tomasz Rutkowski, Leszek Miszczyk, Krzysztof Składowski, Piotr Widlak
    Academic press:
    Jacobs Journal of Radiation Oncology (year: 2016, volume: 3(2), pages: 46030), Publisher: Jacobs Publishers
    Status:
    Published

  6. Systemic effects of ionizing radiation at the proteome and metabolome levels in the blood of cancer patients treated with radiotherapy: the influence of inflammation and radiation toxicity.

    Authors:
    Karol Jelonek, Monika Pietrowska, Piotr Widłak
    Academic press:
    International Journal of Radiation Biology (year: 2017, volume: 93, pages: 683-696), Publisher: Taylor & Francis Online
    Status:
    Published
    DOI:
    10.1080/09553002.2017.1304590 – link to the publication

  7. Dose-dependence of radiotherapy-induced changes in serum levels of choline-containing phospholipids; the importance of lower doses delivered to large volumes of normal tissues

    Authors:
    Karol Jelonek, Aleksandra Krzywoń, Katarzyna Papaj, Paweł Polanowski, Krzysztof Szczepanik, Krzysztof Składowski, Piotr Widłak
    Academic press:
    Strahlentherapie und Onkologie (year: 2021, volume: 197(10), pages: 926-934), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00066-021-01802-4 – link to the publication

  8. Molecular response to induction chemotherapy and its correlation with treatment outcome in head and neck cancer patients by means of NMR-based metabolomics

    Authors:
    Łukasz Boguszewicz, Agata Bieleń, Jarosław Dawid Jarczewski, Mateusz Ciszek, Agnieszka Skorupa , Krzysztof Składowski, Maria Sokół
    Academic press:
    BMC Cancer (year: 2021, volume: 21(1), pages: 410), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12885-021-08137-4 – link to the publication

  9. Systemic Effects of Radiotherapy and Concurrent Chemo-Radiotherapy in Head and Neck Cancer Patients-Comparison of Serum Metabolome Profiles

    Authors:
    Karol Jelonek, Aleksandra Krzywoń, Patrycja Jabłońska, Ewa M. Słomińska, Ryszard T. Smoleński, Joanna Polańska, Tomasz Rutkowski, Jolanta Mrochem- Kwarciak, Krzysztof Składowski, Piotr Widłak
    Academic press:
    Metabolites (year: 2020, volume: 10(2), pages: 60-75), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/metabo100200 – link to the publication

  10. NMR-based metabolomics in real-time monitoring of treatment induced toxicity and cachexia in head and neck cancer: a method for early detection of high risk patients

    Authors:
    Łukasz Boguszewicz, Agata Bieleń, Jolanta Mrochem- Kwarciak, Agnieszka Skorupa, Mateusz Ciszek, Alicja Heyda, Andrzej Wygoda, Anna Kotylak, Krzysztof Składowski, Maria Sokół
    Academic press:
    Metabolomics (year: 2019, volume: 15, pages: 16), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11306-019-1 – link to the publication

  11. Metabolic Profiles of Whole Serum and Serum- Derived Exosomes Are Different in Head and Neck Cancer Patients Treated by Radiotherapy

    Authors:
    Anna Wojakowska, Aneta Zebrowska, Agata Skowronek, Tomasz Rutkowski, Krzysztof Polański, Piotr Widłak, Łukasz Marczak, Monika Pietrowska
    Academic press:
    Journal of Personalized Medicine (year: 2020, volume: 10(4), pages: 229-243), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/jpm10040229 – link to the publication

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