Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Quantitative model for predicting CYP inhibition parameters for novel arylpiperazine derivatives.

2015/17/N/NZ7/04110

Keywords:

QSAR molecular modeling arylpiperazines CYP interactions

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ1_2: Biochemistry

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Szymon Ulenberg 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 149 800 PLN

Project start date (Y-m-d): 2016-03-16

Project end date (Y-m-d): 2019-09-15

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. 3 letnia licencja oprogramowania Accelrys Discovery Studio. (16 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. In Vitro approach for identification of a leading cytochrome P450 isoenzyme responsible for biotransformation of novel arylpiperazine drug candidates and their inhibition potency towards CYP3A4.
    Authors:
    Szymon Ulenberg, Mariusz Belka, Paweł Georgiev, Marek Król, Franciszek Herold, Tomasz Bączek
    Academic press:
    Acta Poloniae Pharmacautica Drug Research (rok: 2020, tom: 7, strony: ), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  2. Molecular docking supplements an in vitro determination of the leading CYP isoform
    Authors:
    Szymon Ulenberg, Joanna Zielińska, Mariusz Belka, Marek Król, Franciszek Herold, Tomasz Bączek
    Academic press:
    Combinatorial Chemistry & High Throughput Screening (rok: 2019, tom: 22, strony: 370-378), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1386207322666190705143322 - link to the publication

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