Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Physicochemical and structural aspects of fibrillogenesis modulated by halogeno-chalcone molecules in the presence of lipid membranes

2015/17/B/ST4/03717

Keywords:

amyloid fibrillogenesis halogen derivatives of chalcone lipid membrane VCD FTIR TEM DSC fluorescence spectrocopy

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_4: Theoretical and computational chemistry
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Cieślik-Boczula 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 378 900 PLN

Project start date (Y-m-d): 2016-02-01

Project end date (Y-m-d): 2019-11-30

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. liofilizator (60 000 PLN)
  2. Laptop.
  3. komputer PC (3 000 PLN)
  4. pH metr.
  5. Tool Box pracujcy w programie Matlab (3 000 PLN)
  6. Vortex z nasadkami (1 900 PLN)
  7. urządzenie wielofunkcyjne biurowe - czarno-biała drukarka z możliwością skanowania i kopiowania (2 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  1. Budowa i funkcje układów białkowo-lipidowych. Structure and function of protein-lipid systems.
    Authors:
    Litwińczuk-Mammadova Adriana, Cieślik-Boczula Katarzyna, Rospenk Maria
    Academic press:
    Wiadomości Chemiczne (rok: 2016, tom: 70, strony: 723-746), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  2. The PPII-to-α-helix transition of poly-L-lysine in methanol/water solvent mixtures accompanied by fibrillar self-aggregation : an influence of fluphenazine molecules.
    Authors:
    Cieślik-Boczula Katarzyna
    Academic press:
    Biophysical Chemistry (rok: 2017, tom: 227, strony: 14-20), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.bpc.2017.05.012 - link to the publication
  3. Anesthetic-dependent changes in the chain-melting phase transition of DPPG liposomes studied using near-infrared spectroscopy supported by PCA.
    Authors:
    Kuć Marta, Cieślik-Boczula Katarzyna, Rospenk Maria
    Academic press:
    Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy (rok: 2017, tom: 186, strony: 37-43), Wydawca: Elsevier, Scienecedirect.com
    Status:
    Published
    DOI:
    10.1016/j.saa.2017.06.003 - link to the publication
  4. Alpha-helix to beta-sheet transition in long-chain poly-L-lysine: formation of alpha-helical fibrils by poly-L-lysine.
    Authors:
    Cieślik-Boczula Katarzyna
    Academic press:
    Biochimie (rok: 2017, tom: 137, strony: 106-114), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.biochi.2017.03.006 - link to the publication
  5. Badania FTIR-ATR i fluorescencyjne układów białkowo-lipidowych. FTIR-ATR and fluorescence studies of protein-lipid systems.
    Authors:
    Litwińczuk-Mammadova Adriana, Cieślik-Boczula Katarzyna, Rospenk Maria
    Academic press:
    Wiadomości Chemiczne (rok: 2017, tom: 71, strony: 109-132), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  6. Influence of phenothiazine molecules on the interactions between positively charged poly-ʟ-lysine and negatively charged DPPC/DPPG membranes.
    Authors:
    Trombik Paulina, Cieślik-Boczula Katarzyna
    Academic press:
    Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy (rok: 2020, tom: 227, strony: 117563/1-117563/11), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.saa.2019.117563 - link to the publication
  7. Influence of resveratrol on interactions between negatively charged DPPC/DPPG membranes and positively charged poly-L-lysine.
    Authors:
    Cieślik-Boczula Katarzyna
    Academic press:
    Chemistry and Physics of Lipids (rok: 2018, tom: 214, strony: 24-34), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.chemphyslip.2018.05.004 - link to the publication
  8. Laurdan emission study of the cholesterol-like effect of long-chain alkylresorcinols on the structure of dipalmitoylphosphocholine and sphingomyelin membranes.
    Authors:
    Zawilska Patrycja, Cieślik-Boczula Katarzyna
    Academic press:
    Biophysical Chemistry (rok: 2017, tom: 221, strony: 45300), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.bpc.2016.11.004 - link to the publication
  9. Effect of phenothiazine compounds on the secondary structure and fibrillogenesis of poly-L-lysine.
    Authors:
    Katarzyna Cieślik-Boczula
    Academic press:
    Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy (rok: 2019, tom: 216, strony: 15-24), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.saa.2019.03.011 - link to the publication
  10. Interaction of anesthetic molecules with α-helix and polyproline II extended helix of long-chain poly-L-lysine.
    Authors:
    Cieślik-Boczula Katarzyna, Rospenk Maria
    Academic press:
    Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy (rok: 2018, tom: 189, strony: 436-442), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.saa.2017.08.045 - link to the publication
  11. NIR studies of cholesterol-dependent structural modification of the model lipid bilayer doped with inhalation anesthetics.
    Authors:
    Kuć Marta, Cieślik-Boczula Katarzyna, Rospenk Maria
    Academic press:
    Journal of Molecular Structure (rok: 2018, tom: 1162, strony: 17-25), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2018.02.086 - link to the publication
  12. Resveratrol modulates fibrillogenesis in a poly L lysine peptide.
    Authors:
    Cieślik-Boczula Katarzyna, Trombik Paulina
    Academic press:
    International Journal of Biological Macromolecules (rok: 2019, tom: 125, strony: 630-641), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2018.12.100 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy