Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Physicochemical and structural aspects of fibrillogenesis modulated by halogeno-chalcone molecules in the presence of lipid membranes

2015/17/B/ST4/03717

Keywords:

amyloid fibrillogenesis halogen derivatives of chalcone lipid membrane VCD FTIR TEM DSC fluorescence spectrocopy

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST4_4: Theoretical and computational chemistry
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Cieślik-Boczula 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 378 900 PLN

Project start date (Y-m-d): 2016-02-01

Project end date (Y-m-d): 2019-11-30

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. liofilizator (60 000 PLN)
  2. komputer PC (3 000 PLN)
  3. pH metr.
  4. urządzenie wielofunkcyjne biurowe - czarno-biała drukarka z możliwością skanowania i kopiowania (2 000 PLN)
  5. Laptop.
  6. Vortex z nasadkami (1 900 PLN)
  7. Tool Box pracujcy w programie Matlab (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  1. Budowa i funkcje układów białkowo-lipidowych. Structure and function of protein-lipid systems.
    Authors:
    Litwińczuk-Mammadova Adriana, Cieślik-Boczula Katarzyna, Rospenk Maria
    Academic press:
    Wiadomości Chemiczne (rok: 2016, tom: 70, strony: 723-746), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Influence of resveratrol on interactions between negatively charged DPPC/DPPG membranes and positively charged poly-L-lysine.
    Authors:
    Cieślik-Boczula Katarzyna
    Academic press:
    Chemistry and Physics of Lipids (rok: 2018, tom: 214, strony: 24-34), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.chemphyslip.2018.05.004 - link to the publication
  3. Interaction of anesthetic molecules with α-helix and polyproline II extended helix of long-chain poly-L-lysine.
    Authors:
    Cieślik-Boczula Katarzyna, Rospenk Maria
    Academic press:
    Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy (rok: 2018, tom: 189, strony: 436-442), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.saa.2017.08.045 - link to the publication
  4. Alpha-helix to beta-sheet transition in long-chain poly-L-lysine: formation of alpha-helical fibrils by poly-L-lysine.
    Authors:
    Cieślik-Boczula Katarzyna
    Academic press:
    Biochimie (rok: 2017, tom: 137, strony: 106-114), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.biochi.2017.03.006 - link to the publication
  5. Badania FTIR-ATR i fluorescencyjne układów białkowo-lipidowych. FTIR-ATR and fluorescence studies of protein-lipid systems.
    Authors:
    Litwińczuk-Mammadova Adriana, Cieślik-Boczula Katarzyna, Rospenk Maria
    Academic press:
    Wiadomości Chemiczne (rok: 2017, tom: 71, strony: 109-132), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  6. Laurdan emission study of the cholesterol-like effect of long-chain alkylresorcinols on the structure of dipalmitoylphosphocholine and sphingomyelin membranes.
    Authors:
    Zawilska Patrycja, Cieślik-Boczula Katarzyna
    Academic press:
    Biophysical Chemistry (rok: 2017, tom: 221, strony: 45300), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.bpc.2016.11.004 - link to the publication
  7. Anesthetic-dependent changes in the chain-melting phase transition of DPPG liposomes studied using near-infrared spectroscopy supported by PCA.
    Authors:
    Kuć Marta, Cieślik-Boczula Katarzyna, Rospenk Maria
    Academic press:
    Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy (rok: 2017, tom: 186, strony: 37-43), Wydawca: Elsevier, Scienecedirect.com
    Status:
    Published
    DOI:
    10.1016/j.saa.2017.06.003 - link to the publication
  8. Effect of phenothiazine compounds on the secondary structure and fibrillogenesis of poly-L-lysine.
    Authors:
    Katarzyna Cieślik-Boczula
    Academic press:
    Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy (rok: 2019, tom: 216, strony: 15-24), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.saa.2019.03.011 - link to the publication
  9. Influence of phenothiazine molecules on the interactions between positively charged poly-ʟ-lysine and negatively charged DPPC/DPPG membranes.
    Authors:
    Trombik Paulina, Cieślik-Boczula Katarzyna
    Academic press:
    Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy (rok: 2020, tom: 227, strony: 117563/1-117563/11), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.saa.2019.117563 - link to the publication
  10. NIR studies of cholesterol-dependent structural modification of the model lipid bilayer doped with inhalation anesthetics.
    Authors:
    Kuć Marta, Cieślik-Boczula Katarzyna, Rospenk Maria
    Academic press:
    Journal of Molecular Structure (rok: 2018, tom: 1162, strony: 17-25), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2018.02.086 - link to the publication
  11. Resveratrol modulates fibrillogenesis in a poly L lysine peptide.
    Authors:
    Cieślik-Boczula Katarzyna, Trombik Paulina
    Academic press:
    International Journal of Biological Macromolecules (rok: 2019, tom: 125, strony: 630-641), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2018.12.100 - link to the publication
  12. The PPII-to-α-helix transition of poly-L-lysine in methanol/water solvent mixtures accompanied by fibrillar self-aggregation : an influence of fluphenazine molecules.
    Authors:
    Cieślik-Boczula Katarzyna
    Academic press:
    Biophysical Chemistry (rok: 2017, tom: 227, strony: 14-20), Wydawca: Elsevier, Sciencedirect.com
    Status:
    Published
    DOI:
    10.1016/j.bpc.2017.05.012 - link to the publication

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