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Evaluation of the CRNDE gene expression and the impact of its newly discovered protein product on selected aspects of tumorigenesis. An attempt to define its role in proliferation, the function associated with a centrosomal localisation and identification of its protein partners.

2015/17/N/NZ5/01392

Keywords:

CRNDEP prolifreation tumorigenesis centrsome cell cycle cytostatics molecular marker

Descriptors:

  • NZ3_2: Cell physiology
  • NZ1_1: Molecular biology
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie Państwowy Instytut Badawczy

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Anna Balcerak 

Number of co-investigators in the project: 3

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2016-04-01

Project end date (Y-m-d): 2020-03-31

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Multi-faceted analysis showing CRNDE gene, transcripts and the lately confirmed micropeptide as key players in ovarian carcinogenesis
    Authors:
    Anna Balcerak, Laura A. Szafron, Tymon Rubel, Bianka Swiderska, Arkadiusz Bonna, Roksana Iwanicka-Nowicka, Jolanta Kupryjanczyk, Lukasz M. Szafron
    Academic press:
    Science Advances (rok: 2023, ), Wydawca: Science
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. HAX1 impact on collective cell migration, cell adhesion, and cell shape is linked to the regulation of actomyosin contractility
    Authors:
    Balcerak A, Trebinska-Stryjewska A, Wakula M, Chmielarczyk M, Smietanka U, Rubel T, Konopinski R, Macech-Klicka E, Zub R, Grzybowska EA
    Academic press:
    Molecular Biology of the Cell (rok: 2019, tom: 30, strony: 3013-3074), Wydawca: American Society of Cell Biology
    Status:
    Published
    DOI:
    10.1091/mbc.E19-05-0304 - link to the publication
  3. RNA-protein interactions: disorder, moonlighting and junk contribute to eukaryotic complexity
    Authors:
    Balcerak A, Trebinska-Stryjewska A, Konopinski R, Wakula M, Grzybowska EA.
    Academic press:
    Open Biology (rok: 2019, tom: 9, strony: 45304), Wydawca: Royal Society
    Status:
    Published
    DOI:
    10.1098/rsob.190096 - link to the publication
  1. CRNDE is involved in the cell cycle , progression, proliferation rate and microtubular cytoskeleton regulation
    Authors:
    Balcerak, M. Kulińczak, L. Buksa, D. Cysewski, T. Rubel, E. A. Grzybowska, A. Dansonka-Mieszkowska, J. Kupryjańczyk, Ł. Szafron
    Conference:
    ASCB/EMBO 2018 meeting, (rok: 2018, ), Wydawca: Molecular Biology of the Cell
    Data:
    konferencja 8-12.12.2018
    Status:
    Published
  2. The CRNDEP localization and interactions suggest its role in RNA metabolism, response to stress and cellular component organization
    Authors:
    A. Balcerak, D. Cysewski, T. Rubel, E. Grzybowska, A. Dansonka-Mieszkowska, L. Szafron
    Conference:
    FEBS Congress 2018 (rok: 2018, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 7-12.07.2018
    Status:
    Published

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