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Dissecting pathomechanisms of idiopathic form of Parkinson's Disease using induced pluripotent stem cells technology

2015/17/B/NZ5/00294

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ5_1: Etiologia chorób człowieka
  • NZ5_7: Leczenie chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Marcin Marek Majka

Number of co-investigators in the project: 6

Call

OPUS 9 – announced on 2015-03-16

Amount awarded
1 515 600 PLN
Project start date
2016-02-16
Project end date
2020-05-15
Project duration
51 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Cyfrowy mikroskop odwrócony.
  2. Inkubator. Cost: 40 000 PLN
  3. Komora filtracyjna CR-670 z mikroskopem stereoskopowym Z-140. Cost: 25 000 PLN
  4. Mikroskop odwrócony. Cost: 30 000 PLN
  5. Nablatowa komora laminarna.
  6. Płatkarka do lodu. Cost: 15 000 PLN
  7. Rotarod. Cost: 65 000 PLN
  8. Stolik zmotoryzowany do mikroskopu. Cost: 45 000 PLN
  9. Urzadzenie sterujace pracą zmotoryzowanych modułów. Cost: 25 000 PLN
  10. Zmotoryzowany fluorescencyjny mikroskop prosty.
  11. Zmotoryzowany rewolwerowy zmieniacz filtrów. Cost: 25 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. Use of 3D Organoids as a Model to Study Idiopathic Form of Parkinson's Disease

    Authors:
    Paula Chlebanowska , Anna Tejchman, Maciej Sułkowski, Klaudia Skrzypek, Marcin Majka
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 694), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21030694 – link to the publication

  2. Highly Effective Protocol for Differentiation of Induced Pluripotent Stem Cells (iPS) into Melanin-Producing Cells

    Authors:
    Maciej Sułkowski, Marta Kot, Bogna Badyra, Anna Paluszkiewicz, Przemysław M. Płonka, Michał Sarna, Dominika Michalczyk-Wetula, Fabio A. Zucca,Luigi Zecca, Marcin Majka
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 12787), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222312787 – link to the publication

  3. Introduction of Exogenous HSV-TK Suicide Gene Increases Safety of Keratinocyte-Derived Induced Pluripotent Stem Cells by Providing Genetic Emergency Exit Switch

    Authors:
    Maciej Sułkowski, Paweł Konieczny, Paula Chlebanowska and Marcin Majka
    Academic press:
    International Journal o f Molecular Sciences (year: 2018, volume: 19, pages: 197), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19010197 – link to the publication

  4. Carbon fibers as a new type of scaffold for 3D organoid modeling to study midbrain-associated neurodegenerative diseases

    Authors:
    Anna Tejchman, Agnieszka Znój, Paula Clebanowska, Aneta Frączek-Szczypta and Marcin Majka
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 5959), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21175959 – link to the publication

  5. Origin of the induced pluripotent stem cells affects their differentiation into dopaminergic neurons

    Authors:
    Paula Chlebanowska, Maciej Sułkowski, Klaudia Skrzypek, Anna Tejchman and Marcin Majka
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 5705), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21165705 – link to the publication

Articles in post-conference publications (2)

  1. Targeting key signaling factors as a way to control microglial activation and induction of neuroinflammation

    Authors:
    Bogna Badyra, Anna Tejchman, Marcin Majka
    Conference:
    44th FEBS Congress, From Molecules to Living Systems (year: 2019, pages: 88-89), Publisher: FEBS OPEN BIO
    Date:
    conference 43652
    Status:
    Published

  2. Comparing neuronal differentiation of human induced pluripotent stem (iPS) cells from different tissue of single donor

    Authors:
    Paula Chlebanowska, Maciej Sulkowski, Anna Tejchman, Marcin Majka
    Conference:
    44th FEBS Congress, From Molecules to Living Systems (year: 2019, pages: 186-187), Publisher: FEBS OPEN BIO
    Date:
    conference 43652
    Status:
    Published

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