Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Ability of CRISPR/dCas9 system and cell-penetrating proteins as the aim of prevention against coronary artery restenosis and thrombosis - in vitro studies

2015/17/D/NZ7/00809

Keywords:

endothelium vascular smooth muscle cells fibroblasts restenosis thrombosis

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Lekarski

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Maciej Gagat 

Number of co-investigators in the project: 5

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 946 600 PLN

Project start date (Y-m-d): 2016-01-27

Project end date (Y-m-d): 2019-11-26

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Automatyczny system fluorescencyjny do obserwacji przyżyciowej komórek wyposażony w inkubator CO2 typu "on stage" (344 000 PLN)
  2. Lodówka 4°C z -20°C zamrażarką (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Cell-penetrating peptides and their utility in genome function modifications (Review)
    Authors:
    Gagat M, Zielińska W, Grzanka A
    Academic press:
    International Journal of Molecular Medicine (rok: 2017, tom: 40, strony: 1615-1623), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijmm.2017.3172 - link to the publication
  2. Letter by Gagat and Grzanka Regarding Article, "Neutrophil Activation of Endothelial Cell-Expressed TRPM2 Mediates Transendothelial Neutrophil Migration and Vascular Injury"
    Authors:
    Gagat M, Grzanka D
    Academic press:
    Circulation Research (rok: 2017, tom: 121, strony: e86), Wydawca: Lippincott Williams & Wilkins
    Status:
    Published
    DOI:
    10.1161/CIRCRESAHA.117.312128 - link to the publication
  3. Letter by Gagat and Grzanka Regarding Article, "Talin-Dependent Integrin Activation Regulates VE-Cadherin Localization and Endothelial Cell Barrier Function".
    Authors:
    Gagat M, Grzanka D
    Academic press:
    Circulation Research (rok: 2019, tom: 125, strony: e11-e12), Wydawca: Lippincott Williams & Wilkins
    Status:
    Published
    DOI:
    10.1161/CIRCRESAHA.119.315450 - link to the publication
  4. Low Effectiveness of the Introduction of pmaxGFP into Primary Human Coronary Endothelial Cells Using Cell-Penetrating Peptides and Nuclear-Localization Sequences in Non-Covalent Interactions
    Authors:
    Zielińska W, Gagat M, Mikołajczyk K, Hałas-Wiśniewska M, Grzanka A
    Academic press:
    Applied Sciences (rok: 2021, tom: 11, strony: 1997), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/app11051997 - link to the publication
  5. CRISPR-based activation of endogenous expression of TPM1 inhibits inflammatory response of primary human coronary artery endothelial and smooth muscle cells induced by recombinant human TNFα
    Authors:
    Gagat M, Zielińska W, Mikołajczyk K, Zabrzyński J, Krajewski A, Klimaszewska-Wiśniewska A, Grzanka D, Grzanka A
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2021, tom: -, strony: -), Wydawca: Frontiers
    Status:
    Accepted for publication
    DOI:
    10.3389/fcell.2021.668032 - link to the publication

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