Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Analysis of mechanisms of drug resistance to trastuzumab in HER2 overexpressing breast cancer based on gene expression changes in selected cell lines.

2015/17/N/NZ2/01932

Keywords:

drug resistance trastuzumab gene expression breast cancer microarrays

Descriptors:

  • NZ2_10:
  • NZ2_2:
  • NZ2_9:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Anna Maria Rusek 

Number of co-investigators in the project: 3

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 99 963 PLN

Project start date (Y-m-d): 2016-02-26

Project end date (Y-m-d): 2019-02-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Book publications / chapters in book publications (1)
  1. Unveiling the molecular mechanism of trastuzumab resistance in SKBR3 and BT474 cell lines for HER2 positive breast cancer
    Authors:
    Kokot A, Gadakh S, Saha I, Gajda E, Łaźniewski M, Rakshit S, Sengupta K, Mollah AF, Denkiewicz M, Górczak K, Claesen J, Burzykowski T, Plewczynski D.
    Academic press:
    Current Issues in Molecular Biology (rok: 2024, tom: 46(3), strony: 2713-2740), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cimb46030171 - link to the publication
  2. One protein to rule them all: The role of CCCTC-binding factor in shaping human genome in health and disease.
    Authors:
    Lazniewski M, Dawson WK, Rusek AM, Plewczynski D
    Academic press:
    Seminars in Cell and Developmental Biology (rok: 2019, tom: 90, strony: 114-127), Wydawca: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
    Status:
    Published
    DOI:
    10.1016/j.semcdb.2018.08.003 - link to the publication
  3. Intermingling of chromosome territories.
    Authors:
    Szczepińska T, Rusek AM, Plewczynski D
    Academic press:
    Genes, Chromosomes and Cancer (rok: 2019, tom: 58(7), strony: 500-506), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1002/gcc.22736. - link to the publication
  1. ANALYSIS OF MECHANISMS OF DRUG RESISTANCE TO TRASTUZUMAB IN HER2 OVEREXPRESSING BREAST CANCER BASED ON GENE AND MICRORNA EXPRESSION CHANGES IN SELECTED CELL LINES
    Authors:
    Anna Rusek
    Book:
    ANALYSIS OF MECHANISMS OF DRUG RESISTANCE TO TRASTUZUMAB IN HER2 OVEREXPRESSING BREAST CANCER BASED ON GENE AND MICRORNA EXPRESSION CHANGES IN SELECTED CELL LINES (rok: 2022, tom: ISBN: 978-83-963859-9-4, strony: 1-213), Wydawca: UMB w Białystoku
    Status:
    Published