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Design, synthesis, X-ray structural studies and biological evaluation of novel chalcone derivatives - potential antimitotic agents

2015/17/B/ST4/03701

Keywords:

chalcones organic synthesis structure electron density distribution microtubules

Descriptors:

  • ST4_4: Theoretical and computational chemistry
  • ST5_16:
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Kubicki 

Number of co-investigators in the project: 7

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 887 400 PLN

Project start date (Y-m-d): 2016-03-03

Project end date (Y-m-d): 2020-09-02

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Termostat blokowy grzeiqco/chlodz4cy ThermoStat c basic.
  2. Agregat chłodniczy z pompą obiegową i elektronicznym regulatorem temperatury (12 000 PLN)
  3. BIOVIA Discovery Studio (25 000 PLN)
  4. Komputer o specyficznej konfiguracji (8 000 PLN)
  5. Wyparka z systemem próżniowym (34 000 PLN)
  6. Termostat blokowy grzejąco /chłodzący ThermoStat C.
  7. Zestaw do syntezy równoległej (37 000 PLN)
  8. Laptop (2 szt.) (7 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (2)
  1. Two new polymorphic forms of combretastatin A-4, an antitumour agent
    Authors:
    Anita M. Grzeskiewicz, Tomasz Stefanski, Zbigniew Dutkiewicz, Daria Busko and Maciej Kubicki
    Academic press:
    Acta Crystallographica part C (rok: 2020, tom: 76, strony: 958-964), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1107/S205322962001236X - link to the publication
  2. Weak intermolecular interactions in a series of biologically active 4 -methylthio-trans -stilbenes
    Authors:
    Anita M. Grześkiewicz, Tomasz Stefański, Zbigniew Dutkiewicz and Maciej Kubicki
    Academic press:
    Acta Crystallographica part C (rok: 2022, tom: 78, strony: 107-115), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1107/S2053229622000420 - link to the publication
  3. Solvent influence on the crystal packing of 6-aminothiocytosine
    Authors:
    Anita M. Grzeskiewicz, Agata Ostrowska and Maciej Kubicki
    Academic press:
    Acta Crystallographica part C (rok: 2020, tom: 76, strony: 250-257), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1107/S2053229620001692 - link to the publication
  4. Weak Intermolecular Interactions in a Series of Bioactive Oxazoles
    Authors:
    Anita M. Grześkiewicz , Tomasz Stefański and Maciej Kubicki
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 3024 (1-12)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26103024 - link to the publication
  5. Role of Staple Molecules in the Formation of S···S Contact in Thioamides: Experimental Charge Density and Theoretical Studies
    Authors:
    Agata Owczarzak, Z. Dutkiewicz, R. Kurczab, W. Pietrus, M. Kubicki, A. M. Grzeskiewicz
    Academic press:
    Crystal Growth & Design (rok: 2019, tom: 19, strony: 7324-7335), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.cgd.9b01204 - link to the publication
  6. Charge density distribution in the crystals of N-nbutyltetrachlorophthalimide. Atoms-in-molecules analysis of different types of halogen interactions
    Authors:
    Agata Owczarzak, Grzegorz Dutkiewicz, Maciej Kubicki
    Academic press:
    CrystEngComm (rok: 2019, tom: 21, strony: 7048-7056), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/c9ce01120j - link to the publication
  7. THE SYNTHESIS OF NOVEL THIODERIVATIVE CHALCONES AND THEIR INFLUENCE ON NF-κB, STAT3 AND Nrf2 SIGNALING PATHWAYS IN COLORECTAL CANCER CELLS
    Authors:
    Katarzyna Papierska, Violetta Krajka-Kuźniak, Tomasz Stefański, Maciej Kubicki
    Academic press:
    Sci.Rep. , Wydawca: Naturę group
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Design, synthesis and crystal structure of novel chalcone derivatives as potential microtubule targeting agents
    Authors:
    T.Stefański, R. Kurczab, Z. Dutkiewicz, A. Korzański, A. Gielara-Korzańska, M. Kubicki
    Conference:
    VIII Konwersatorium Chemii Medycznej (rok: 2016, ), Wydawca: UM Lublin
    Data:
    konferencja 15-17.09.2016
    Status:
    Published
  2. Design, synthesis, X-ray studies and biological evaluation of novel chalcone derivatives - potential microtubule targeting agents
    Authors:
    T. Stefański, R. Kurczab, A. Korzański, K. Skonieczka, B. Grolik, E. Kania, B. Bojko, Z. Dutkiewicz, A. Gielara-Korzańska, R. Mikstacka, A. Hogendorf, M. Kubicki
    Conference:
    10th Joint Meeting on Medicinal Chemistry (rok: 2017, ), Wydawca: Croatian Chemical Society
    Data:
    konferencja 25-28.06
    Status:
    Published

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