Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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MicroRNA profiling in cellular models of Huntington's disease generated using iPSC technology

2015/17/N/NZ2/01916

Keywords:

microRNA Huntington's disease iPSC stem cells deep sequencing

Descriptors:

  • NZ2_2:
  • NZ1_1:
  • NZ3_8:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Emilia Barbara Kozłowska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 149 200 PLN

Project start date (Y-m-d): 2016-03-15

Project end date (Y-m-d): 2021-03-14

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (1)
  1. MicroRNA Profiling During Neural Di erentiation of Induced Pluripotent Stem Cells
    Authors:
    "Katarzyna Kulcenty, Joanna P. Wroblewska, Marcin Rucinski, Emilia Kozlowska, Karol Jopek and Wiktoria M. Suchorska"
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 3651), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20153651 - link to the publication
  2. What, When and How to Measure—Peripheral Biomarkers in Therapy of Huntington's Disease
    Authors:
    Lukasz Przybyl, Magdalena Wozna-Wysocka, Emilia Kozlowska, Agnieszka Fiszer
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 1561), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22041561 - link to the publication
  3. Artificial miRNAs targeting CAG repeat expansion in ORFs cause rapid deadenylation and translation inhibition of mutant transcripts
    Authors:
    Adam Ciesiolka, Anna Stroynowska‑Czerwinska, Paweł Joachimiak, Agata Ciolak, Emilia Kozlowska, Michal Michalak, Magdalena Dabrowska, Marta Olejniczak, Katarzyna D. Raczynska, Dominika Zielinska, Magdalena Wozna‑Wysocka, Wlodzimierz J. Krzyzosiak, Agnieszka Fiszer
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2021, tom: 78, strony: 1577–1596), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-020-03596-7 - link to the publication
  4. Generation of new isogenic models of Huntington's disease using CRISPR-Cas9 technology
    Authors:
    Magdalena Dabrowska, Agata Ciolak, Emilia Kozlowska, Agnieszka Fiszer, Marta Olejniczak
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 1854), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21051854 - link to the publication
  5. What, When and How to Measure—Peripheral Biomarkers in Therapy of Huntington's Disease
    Authors:
    Lukasz Przybyl, Magdalena Wozna-Wysocka, Emilia Kozlowska, Agnieszka Fiszer
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 1561), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22041561 - link to the publication
  6. Generation of human iPS cell line IBCHi001-A from dentatorubral–pallidoluysian atrophy patient's fibroblasts
    Authors:
    Emilia Kozlowska, Agata Ciolak, Marta Olejniczak, Agnieszka Fiszer,
    Academic press:
    Stem Cell Research (rok: 2019, tom: 39, strony: 101512), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2019.101512 - link to the publication
  7. Generation of human iPS cell line IBCHi002-A from spinocerebellar ataxia type 3/Machado-Joseph disease patient's fibroblasts
    Authors:
    Agata Ciolak, Wlodzimierz J. Krzyzosiak, Emilia Kozlowska, Agnieszka Fiszer
    Academic press:
    Stem Cell Research (rok: 2020, tom: 45, strony: 101796), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2020.101796 - link to the publication
  8. Generation of new isogenic models of Huntington's disease using CRISPR-Cas9 technology
    Authors:
    Magdalena Dabrowska, Agata Ciolak, Emilia Kozlowska, Agnieszka Fiszer, Marta Olejniczak
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 1854), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21051854 - link to the publication
  9. Generation of human iPS cell line IBCHi002-A from spinocerebellar ataxia type 3/Machado-Joseph disease patient's fibroblasts
    Authors:
    Agata Ciolak, Wlodzimierz J. Krzyzosiak, Emilia Kozlowska, Agnieszka Fiszer
    Academic press:
    Stem Cell Research (rok: 2020, tom: 45, strony: 101796), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2020.101796 - link to the publication
  10. Artificial miRNAs targeting CAG repeat expansion in ORFs cause rapid deadenylation and translation inhibition of mutant transcripts
    Authors:
    Adam Ciesiolka, Anna Stroynowska‑Czerwinska, Paweł Joachimiak, Agata Ciolak, Emilia Kozlowska, Michal Michalak, Magdalena Dabrowska, Marta Olejniczak, Katarzyna D. Raczynska, Dominika Zielinska, Magdalena Wozna‑Wysocka, Wlodzimierz J. Krzyzosiak, Agnieszka Fiszer
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2021, tom: 78, strony: 1577–1596), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-020-03596-7 - link to the publication
  11. MicroRNA Profiling During Neural Di erentiation of Induced Pluripotent Stem Cells
    Authors:
    "Katarzyna Kulcenty, Joanna P. Wroblewska, Marcin Rucinski, Emilia Kozlowska, Karol Jopek and Wiktoria M. Suchorska"
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 3651), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20153651 - link to the publication
  12. Generation of human iPS cell line IBCHi001-A from dentatorubral–pallidoluysian atrophy patient's fibroblasts
    Authors:
    Emilia Kozlowska, Agata Ciolak, Marta Olejniczak, Agnieszka Fiszer,
    Academic press:
    Stem Cell Research (rok: 2019, tom: 39, strony: 101512), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2019.101512 - link to the publication
  1. Ribosome meets RISC at expanded CAG repeat tract-allele-selective RNAi approach for therapy of polyglutamine diseases
    Authors:
    P. Joachimiak, A. Ciesiołka, A. Łużna, E. Kozłowska, M. Michalak, W. Krzyżosiak, A. Fiszer
    Conference:
    44th FEBS Congress (rok: 2019, ), Wydawca: WILEY
    Data:
    konferencja 2019-07-06-2019-07-11
    Status:
    Published

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