Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Interference of fenofibrate with the invasive potential of prostate cancer cells modulated by chemotherapeutics

2015/17/B/NZ3/01040

Keywords:

prostate cancer chemotherapy fenofibrate Cx43 infammation stem cells

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jarosław Czyż 

Number of co-investigators in the project: 8

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 749 800 PLN

Project start date (Y-m-d): 2016-02-18

Project end date (Y-m-d): 2020-02-17

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zestaw do immunoblottingu (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (2)
  1. Fenofibrate Interferes with the Diapedesis of Lung Adenocarcinoma Cells through the Interference with Cx43/EGF-Dependent Intercellular Signaling
    Authors:
    Piwowarczyk K, Kwiecień E, Sośniak J, Zimoląg E, Guzik E, Sroka J, Madeja Z, Czyż J.
    Academic press:
    Cancers (rok: 2018, tom: 10(10), strony: pii:E363), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers10100363 - link to the publication
  2. Fenofibrate Augments the Sensitivity of Drug-Resistant Prostate Cancer Cells to Docetaxel
    Authors:
    Luty M, Piwowarczyk K, Łabędź-Masłowska A, Wróbel T, Szczygieł M, Catapano J, Drabik G, Ryszawy D, Kędracka-Krok S, Madeja Z, Siedlar M, Elas M, Czyż J.
    Academic press:
    Cancers (rok: 2019, tom: 11(1), strony: pii: E77), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11010077 - link to the publication
  3. Therapeutic potential of monoterpene α-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro.
    Authors:
    Pudełek M, Catapano J, Kochanowski P, Mrowiec K, Janik-Olchawa N, Czyż J, Ryszawy D
    Academic press:
    Fitoterapia (rok: 2019, tom: 134, strony: 172-181), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fitote.2019.02.020 - link to the publication
  4. CD44 + cells determine fenofibrate-induced microevolution of drug-resistance in prostate cancer cell populations
    Authors:
    Wróbel T, Luty M, Catapano J, Karnas E, Szczygieł M, Piwowarczyk K, Ryszawy D, Drabik G, Zuba-Surma E, Siedlar M, Madeja Z, Elas M, Czyż J1
    Academic press:
    Stem Cells (rok: 2020, tom: 38(12), strony: 1544-1556), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/stem.3281. - link to the publication
  5. Connexin-dependent intercellular stress signaling in tissue homeostasis and tumor development
    Authors:
    Czyż J, Piwowarczyk K, Paw M, Luty M, Wróbel T, Catapano J, Madeja Z, Ryszawy D
    Academic press:
    Acta Biochimica Polonica (rok: 2017, tom: 64(3), strony: 377-389), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2017_1592 - link to the publication
  6. Connexin43high prostate cancer cells induce endothelial connexin43 up-regulation through the activation of intercellular ERK1/2-dependent signaling axis
    Authors:
    Piwowarczyk K, Paw M, Ryszawy D, Rutkowska-Zapała M, Madeja Z, Siedlar M, Czyż J
    Academic press:
    European Journal of Cell Biology (rok: 2017, tom: ND, strony: ND), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejcb.2017.03.012 - link to the publication
  7. High bisphenol A concentrations augment the invasiveness of tumor cells through Snail-1/Cx43/ERRγ-dependent epithelial-mesenchymal transition
    Authors:
    Ryszawy D, Pudełek M, Kochanowski P, Janik-Olchawa N, Bogusz J, Rąpała M, Koczurkiewicz P, Mikołajczyk J, Borek I, Kędracka-Krok S, Karnas E, Zuba-Surma E, Madeja Z, Czyż J.
    Academic press:
    Toxicol In Vitro (rok: 2020, tom: 62, strony: 104676), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2019.104676 - link to the publication
  8. Invasive Cx43high sub-line of human prostate DU145 cells displays increased nanomechanical deformability
    Authors:
    Piwowarczyk K, Sarna M, Ryszawy D, Czyż J
    Academic press:
    Acta Biochimica Polonica (rok: 2017, tom: 64(3), strony: 445-449), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2017_1593 - link to the publication
  1. Fenofibrate augments the sensitivity of drugresistant human prostate cancer DU145 cells to docetaxel
    Authors:
    M. Luty, K. Szpak, T. Wrobel, D. Ryszawy, Z. Madeja, J. Czyz
    Conference:
    42nd FEBS Congress (rok: 2017, ), Wydawca: FEBS
    Data:
    konferencja September 10-14, 2017
    Status:
    Published
  2. Fenofibrate attenuates pro-tumorigenic potential of cancer stem cell-like cells in drugresistant prostate cancer cell populations
    Authors:
    T. Wrobel, E. Karnas, J. Catapano, M. Luty, D. Ryszawy, J. Czyz
    Conference:
    42nd FEBS Congress (rok: 2017, ), Wydawca: FEBS
    Data:
    konferencja Septemeber 10-14, 2017
    Status:
    Published

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