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Information on the principal investigator and host institution

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Protein and gene expression analysis in the course of renal cancer stem-like cells' primary resistance to sorafenib in hypoxia in three-dimensional in vitro model.

2015/17/N/NZ5/00691

Keywords:

drug resistance anti-angiogenic therapy renal cell carcinoma 3D cell cultures tyrosine kinase inhibitors stem-like cells

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ1_9: Biotechnology
  • NZ2_3: Proteomics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Wojskowy Instytut Medyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Zofia Bielecka 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 149 040 PLN

Project start date (Y-m-d): 2016-01-26

Project end date (Y-m-d): 2019-01-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (4)
  1. Hypoxic 3D in vitro culture models reveal distinct resistance processes to TKIs in renal cancer cells.
    Authors:
    Bielecka ZF, Malinowska A, Brodaczewska KK, Klemba A, Kieda C, Krasowski P, Grzesiuk E, Piwowarski J, Czarnecka AM, Szczylik C.
    Academic press:
    Cell & Bioscience (rok: 2017, tom: 0,340972222222222, strony: eCollection 2017), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13578-017-0197-8 - link to the publication
  1. Laminin and poly-D-lysine pre-coating enable effective drug testing in renal cell carcinoma
    Authors:
    Z.F.Bielecka, K.K.Brodaczewska, K.Maliszewska-Olejniczak, C.Szczylik, A.M.Czarnecka
    Conference:
    32nd Ernst Klenk Symposium in Molecular Medicine (rok: 2016, ), Wydawca: Centre for Molecular Medicine Cologne
    Data:
    konferencja 8-10/12/2016
    Status:
    Published
  2. Parametry hodowli trójwymiarowych a reakcja komórek raka nerki na inhibitory kinaz tyrozynowych (TKI) i inhibitory kinazy mTOR/cytostatyki.
    Authors:
    Z.F. Bielecka, K.K. Brodaczewska, C. Szczylik, A.M. Czarnecka
    Conference:
    IV Kongres Onkologii Polskiej (rok: 2016, ), Wydawca: NOWOTWORY. Journal of Oncology.
    Data:
    konferencja 12-15.10.2016, Łódź, Polska
    Status:
    Published
  3. Lekooporność na inhibitory kinaz tyrozynowych w modelach dwu- i trójwymiarowych in vitro raka nerkowokomórkowego.
    Authors:
    Z.F. Bielecka, A. Malinowska, P. Krasowski, S. Lewicki, K.K. Brodaczewska, C. Kieda, A.M. Czarnecka, C. Szczylik
    Conference:
    7 Konferencja "Postępy w Badaniach Biomedycznych" (rok: 2016, ), Wydawca: SKN przy Warszawskim Uniwersytecie Medycznym
    Data:
    konferencja 10-11.12.2016, Warszawa, Polska
    Status:
    Published
  4. Protein expression profiling of sorafenib-resistant human renal cancer stem-like cells in three-dimensional in vitro model
    Authors:
    Z. F. Bielecka, A. Malinowska, P. Krasowski, C. Kieda, C. Szczylik
    Conference:
    19th Euro Congress on Cancer Science and Therapy (rok: 2017, ), Wydawca: Cancer Science
    Data:
    konferencja 17-19-07-2017
    Status:
    Published

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