Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Searching for novel genes essential for human oligo- and azoospermia - mouse 'knockout' model

2015/17/B/NZ2/01157

Keywords:

infertility genetic causes of male infertility animal model experiments gene 'knockout'

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_5: Diagnostics in human diseases
  • NZ2_11: Genetic epidemiology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Genetyki Człowieka PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Kurpisz 

Number of co-investigators in the project: 8

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 566 440 PLN

Project start date (Y-m-d): 2016-02-18

Project end date (Y-m-d): 2020-02-16

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer stacjonarny (5 000 PLN)
  2. Spektrofotometr Qubit® 3.0 Fluorometer (8 500 PLN)
  3. Lodówko-zamrażarka.
  4. Narzędzia mikrochirurgiczne (3 000 PLN)
  5. doposażenie mikroskopu o system do dokumentacji mikroskopowej CellF (Olympus) oraz filtry fluorescencyjne (46 500 PLN)
  6. notebook.
  7. aparat do automatycznej izolacji kwasów nukleinowych (MagCore HF16) (65 000 PLN)
  8. aparat do elektroforezy (8 000 PLN)
  9. zestaw do analizy Western blot 13000 pln – doposażenie laboratorium w niezbędny zestaw do przeprowadzenia doswiadczeń (13 000 PLN)
  10. Skaner.

Information in the final report

  • Publication in academic press/journals (9)
  1. Novel Mutations Segregating with Complete Androgen Insensitivity Syndrome and their Molecular Characteristics
    Authors:
    Malcher A, Jedrzejczak P, Stokowy T, Monem S, Nowicka-Bauer K, Zimna A, Czyzyk A, Maciejewska-Jeske M, Meczekalski B, Bednarek-Rajewska K, Wozniak A, Rozwadowska N, Kurpisz M
    Academic press:
    Int J Mol Sci (rok: 2019, tom: 20, strony: pii: E5418), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20215418 - link to the publication
  2. Evaluation of seminal plasma HSPA2 protein as a biomarker of human spermatogenesis status.
    Authors:
    Karolina Nowicka-Bauer1,2, Agnieszka Malcher, Olga Włoczkowska, Marzena Kamieniczna, Marta Olszewska, Maciej K. Kurpisz
    Academic press:
    Reproductive Biology (rok: 2021, tom: -, strony: -), Wydawca: ELSEVIER
    Status:
    Submitted
    DOI:
    BRAK - link to the publication
  3. Chromosome (re)positioning in spermatozoa of fathers and sons – carriers of reciprocal chromosome translocation (RCT)
    Authors:
    Olszewska , Wiland E, Huleyuk N, Fraczek M, Midro AT, Zastavna D, Kurpisz M
    Academic press:
    BMC Med Genomics (rok: 2019, tom: 12, strony: 30), Wydawca: Springer Nature/BioMed Central Ltd
    Status:
    Published
    DOI:
    10.1186/s12920-018-0470-7 - link to the publication
  4. Variants in GCNA, X‐linked germ‐cell genome integrity gene, identified in men with primary spermatogenic failure
    Authors:
    Hardy JJ, Wyrwoll MJ, Mcfadden W, Malcher A, Rotte N, Pollock NC, Munyoki S, Veroli MV, Houston BJ, Xavier MJ, Kasak L, Punab M, Laan M, Kliesch S, Schlegel P, Jaffe T, Hwang K, Vukina J, Brieno-Enriquez MA, Orwig K, Yanowitz J, Buszczak M, Veltman JA, Oud M, Nagirnaja L, Olszewska M, O'Bryan MK, Conrad DF, Kurpisz M, Tuttelmann F, Yatsenko AN, GEIMINI Consortium
    Academic press:
    Human Genetics (rok: 2021, tom: 140, strony: 1169-1182), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00439-021-02287-y - link to the publication
  5. Familial infertility (azoospermia and cryptozoospermia) in two brothers – carriers of t(1;7) complex chromosomal rearrangement (CCR): molecular cytogenetic analysis
    Authors:
    Olszewska M, Stokowy T, Pollock N, Huleyuk N, Georgiadis A, Yatsenko S, Zastavna D, Yatsenko AN, Kurpisz M
    Academic press:
    Int J Mol Sci (rok: 2020, tom: 21, strony: 4559), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21124559 - link to the publication
  6. Analysis of sperm chromosomes in six carriers of rare and common Robertsonian translocations
    Authors:
    Olszewska M, Wiland E, Wanowska E, Huleyuk N, Chernykh VB, Zastavna D, Kurpisz M
    Academic press:
    Postepy Hig Med Dosw (rok: 2021, tom: 75, strony: 199-210), Wydawca: Sciendo (De Gruyter Poland Sp. z o.o.)
    Status:
    Published
    DOI:
    10.5604/01.3001.0014.8122 - link to the publication
  7. Human sperm proteins identified by 2-dimensional electrophoresis and mass spetrometry and their relevance to a transcriptomic analysis
    Authors:
    Nowicka-Bauer K, Ozgo M, Lepczynski A, Kamieniczna M, Malcher A, Skrzypczak W, Kurpisz M
    Academic press:
    Reproductive Biology (rok: 2018, tom: 18, strony: 151-160), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.repbio.2018.02.003 - link to the publication
  8. Sperm mitochondrial dysfunction and oxidative stress as possible reasons for isolated asthenozoospermia
    Authors:
    Nowicka-Bauer K, Lepczynski A, Ozgo M, Kamieniczna M, Fraczek M, Stanski L, Olszewska M, Malcher A, Skrzypczak W, Kurpisz MK
    Academic press:
    J Physiol Pharmacol (rok: 2018, tom: 69, strony: 403-417), Wydawca: the Polish Physiological Society
    Status:
    Published
    DOI:
    10.26402/jpp.2018.3.05 - link to the publication
  9. The effect of Robertsonian translocations on the intranuclear positioning of NORs (nucleolar organizing regions) in human sperm cells
    Authors:
    Wiland E, Olszewska M, Huleyuk N, Chernykh VB, Kurpisz M
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 2213), Wydawca: Springer Nature Publishing AG
    Status:
    Published
    DOI:
    10.1038/s41598-019-38478-x - link to the publication

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