Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Analysis of DNA methylation pattern in spermatozoa of infertile men with oligozoospermia

2015/17/D/NZ5/03442

Keywords:

sperm DNA methylation pattern male infertility oligozoospermia chromosomes/chromatin in sperm

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ5_5: Diagnostics in human diseases
  • NZ2_5: Cell genetics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Genetyki Człowieka PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Olszewska 

Number of co-investigators in the project: 5

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 639 640 PLN

Project start date (Y-m-d): 2016-02-03

Project end date (Y-m-d): 2020-08-02

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer stacjonarny z drukarką (7 000 PLN)
  2. aparat do elektroforezy (6 000 PLN)
  3. zestaw pipet (3 000 PLN)
  4. mikroskop fluorescencyjny (220 000 PLN)
  5. mikrowirówka stołowa na probówki do 2 ml (2 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Chromosome (re)positioning in spermatozoa of fathers and sons – carriers of reciprocal chromosome translocation (RCT)
    Authors:
    Olszewska M, Wiland E, Huleyuk N, Fraczek M, Midro AT, Zastavna D, Kurpisz M
    Academic press:
    BMC Med Genomics (rok: 2019, tom: 12, strony: 30), Wydawca: Springer Nature/BioMed Central Ltd
    Status:
    Published
    DOI:
    10.1186/s12920-018-0470-7 - link to the publication
  2. Global 5mC and 5hmC DNA levels in human sperm subpopulations with differentially protaminated chromatin in normo- and oligoasthenozoospermic males
    Authors:
    Marta Olszewska, Oliwia Kordyl, Marzena Kamieniczna, Monika Fraczek, Piotr Jedrzejczak, Maciej Kurpisz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 4516), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23094516 - link to the publication
  3. How much, if anything, do we know about sperm chromosomes of Robertsonian translocation carriers?
    Authors:
    Wiland E, Olszewska M, Woźniak T, Kurpisz M
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2020, tom: 77, strony: 4765-4785), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00018-020-03560-5 - link to the publication
  4. Analysis of sperm chromosomes in six carriers of rare and common Robertsonian translocations
    Authors:
    Olszewska M, Wiland E, Wanowska E, Huleyuk N, Chernykh VB, Zastavna D, Kurpisz M
    Academic press:
    Post Hig Med Dosw (rok: 2021, tom: -, strony: -), Wydawca: Index Copernicus International, Warszawa
    Status:
    Published
    DOI:
    10.5604/01.3001.0014.8122 - link to the publication
  5. The effect of Robertsonian translocations on the intranuclear positioning of NORs (nucleolar organizing regions) in human sperm cells
    Authors:
    Wiland E, Olszewska M, Huleyuk N, Chernykh VB, Kurpisz M
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 2213), Wydawca: Springer Nature Publishing AG
    Status:
    Published
    DOI:
    10.1038/s41598-019-38478-x - link to the publication

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