Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The impact of the integrin alpha-2 beta-1 on collagen metabolism regulation in atrial fibroblasts.

2015/17/B/NZ5/01382

Keywords:

integrin collagen atrial human fibroblasts mechanical stress

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jacek Drobnik 

Number of co-investigators in the project: 5

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 898 800 PLN

Project start date (Y-m-d): 2016-02-16

Project end date (Y-m-d): 2020-10-15

Project duration:: 56 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Termocykler Real Time PCR; Light Cycler 96; Roche Diagnostics Polska sp. z o.o. (136 000 PLN)
  2. ADAM-MC - automatyczny licznik komórek wraz z zestawem startowym na 400 oznaczeń (38 500 PLN)
  3. Spektrofotometr NanoDrop 2000 EU; Thermo Scientific Inc. (46 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. The Stiffness of Cardiac Fibroblast Substrates Exerts a Regulatory Influence on Collagen Metabolism via α2β1 Integrin, FAK and Src Kinases.
    Authors:
    Gałdyszyńska M, Radwańska P, Szymański J, Drobnik J.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10123506. - link to the publication
  2. The stiffness-controlled release of interleukin-6 by cardiac fibroblasts is dependent on integrin α2β1
    Authors:
    Małgorzata Gałdyszyńska, Justyna Bobrowska, Małgorzata Lekka, Paulina Radwańska, Lucyna Piera, Jacek Szymański, Jacek Drobnik
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2020, tom: nie dotyczy, strony: 45301), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1111/jcmm.15974 - link to the publication
  3. Stiff substrates inhibit collagen accumulation via integrin α2β1, FAK and Src kinases in human atrial fibroblast and myofibroblast cultures derived from patients with aortal stenosis.
    Authors:
    Gałdyszyńska M., Zwoliński R., Piera L., Szymański J., Jaszewski R., Drobnik J.
    Academic press:
    Biomedicine & Pharmacotherapy   (rok: 2023, tom: 159, strony: 114289), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2023.114289 - link to the publication
  1. RELEASE OF INTERLEUKIN-6 IS DEPENDENT ON a2b1 INTEGRIN
    Authors:
    M. GALDYSZYNSKA, P. RADWANSKA , J. DROBNIK
    Conference:
    XXVIII Congress of the Polish Physiological Society (rok: 2021, ), Wydawca: Polish Physiological Society
    Data:
    konferencja 2021.09.15-17
    Status:
    Published
  2. Collagen metabolism within a cardiac fibroblasts culture is dependent on physical properties of the cell environment
    Authors:
    Małgorzata Gałdyszyńska, Jacek Drobnik
    Conference:
    Matrix Biology Europe (rok: 2018, ), Wydawca: WILEY
    Data:
    konferencja 2018-07-21 - 2018-07-24
    Status:
    Published
  3. Regulacyjny wpływ twardości podłoża oraz integryny α2β1, kinazy Src i FAK na akumulację kolagenu w hodowlach miofibroblastów z przedsionków serca
    Authors:
    Małgorzata Galdyszyńska, Radosław Zwoliński, Lucyna Piera, Jacek Szymański, Ryszard Jaszewski, Jacek Drobnik
    Conference:
    XXVI Sympozjum Sekcji Kardiologii Eksperymentalnej Polskiego Towarzystwa Kardiologicznego (rok: 2022, ), Wydawca: Polish Academy of Sciences Krakow Branch, Jagiellonian University Medical College
    Data:
    konferencja 27-29 październik 2022
    Status:
    Published
  4. Stiff substrate inhibits collagen accumulation via integrin α2β1, FAK and Src kinases in human cardiac fibroblasts derived from patients with aortal stenosis
    Authors:
    Małgorzata Gałdyszyńska, Radosław Zwoliński, Lucyna Piera, Jacek Szymański, Ryszard Jaszewski, Jacek Drobnik
    Conference:
    Matrix Biology Europe (rok: 2022, ), Wydawca: Societa Italiano per lo Studio del Connecttivo
    Data:
    konferencja 28-30 wrzesień 2022
    Status:
    Published

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