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Effect of alpha-1 antitrypsin on neutrophil phenotypes: new regulatory mechanisms of chronic inflammation in the respiratory tract.

2015/17/B/NZ5/01370

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ5_9: Inne zagadnienia pokrewne

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Instytut Gruźlicy i Chorób Płuc

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Sabina Marija Janciauskiene-Wallmark

Number of co-investigators in the project: 4

Call

OPUS 9 – announced on 2015-03-16

Amount awarded
1 202 325 PLN
Project start date
2016-03-23
Project end date
2022-03-22
Project duration
72 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (7)

  1. Does urinary peptide content differ between COPD patients with and without inherited alpha-1 antitrypsin deficiency?

    Authors:
    A.Carleo, J. Chorostowska-Wynimko,T. Koeck, H.Mischak, M. Czajkowska-Malinowska, A.Rozy, T. Welte, S. Janciauskiene
    Academic press:
    International Journal of COPD (year: 2017, volume: nie dotyczy, pages: 829–837), Publisher: Dove Press
    Status:
    Published
    DOI:
    10.2147/COPD.S125240 – link to the publication

  2. The Beneficial Effects of Antioxidants in Health And Diseases.

    Authors:
    S.Janciauskiene
    Academic press:
    Chronic obstructive pulmonary diseases (year: 2020, volume: 7(3), pages: 182-202), Publisher: COPD Foundation
    Status:
    Published
    DOI:
    10.15326/jcopdf.7.3.2019.0152 – link to the publication

  3. The Delivery of α1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore.

    Authors:
    Srinu Tumpara, Beatriz Martinez-Delgado, Gema Gomez-Mariano, Bin Liu, David S. DeLuca, Elena Korenbaum, Danny Jonigk, Frank Jugert, Florian M. Wurm, Maria J. Wurm, Tobias Welte and Sabina Janciauskiene
    Academic press:
    Frontiers in Pharmacology (year: 2020, volume: 11, pages: artykuł 983), Publisher: Frontiers Media S.A
    Status:
    Published
    DOI:
    10.3389/fphar.2020.00983 – link to the publication

  4. Plasma Acute Phase Proteins as Predictors of Chronic Lung Allograft Dysfunction in Lung Transplant Recipients

    Authors:
    Sabina Janciauskiene,Pierre-Joseph Royer,Jan Fuge,Sabine Wrenger,Joanna Chorostowska- Wynimko,Christine Falk,Tobias Welte,Martine Reynaud-Gaubert,Antoine Roux,Adrien Tissot,Antoine Magnan
    Academic press:
    Journal of Inflammation Research (year: 2020, volume: 13, pages: 1021-1028), Publisher: Dovepress
    Status:
    Published
    DOI:
    10.2147/JIR.S272662 – link to the publication

  5. Alpha1-antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance

    Authors:
    S. Janciauskiene, S. Tumpara, M.Wiese, S. Wrenger, V. Vijayan, F. Gueler, R. Chen, K. Madyaningrana, R. Mahadeva, T. Welte, S. Immenschuh, J.Chorostowska-Wynimko
    Academic press:
    JOURNAL OF LEUKOCYTE BIOLOGY (year: 2017, volume: 102, pages: 1127-1141), Publisher: Wiley on behalf of the Society for Leukocyte Biology (United States)
    Status:
    Published
    DOI:
    10.1189/jlb.3A0317-124R – link to the publication

  6. The Multifaceted Effects of Alpha1-Antitrypsin on Neutrophil Functions.

    Authors:
    Sabina Janciauskiene, Sabine Wrenger, Stephan Immenschuh, Beata Olejnicka, Timm Greulich, Tobias Welte and Joanna Chorostowska-Wynimko
    Academic press:
    Frontiers in Pharmacology (year: 2018, volume: 9/Artykuł 341, pages: 46035), Publisher: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fphar.2018.00341/full – link to the publication

  7. Post-Translational Modifications of Circulating Alpha-1-Antitrypsin Protein

    Authors:
    Urszula Lechowicz, Stefan Rudzinski, Aleksandra Jezela-Stanek, Sabina Janciauskiene, Joanna Chorostowska-Wynimko
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 2, pages: 46040), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239187 – link to the publication

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