Projects funded by the NCN
Influence of the hinge region of mouse IgG3 antibodies on their unique features and functions.
2015/17/N/NZ1/00039
Keywords:
mouse IgG3 immunoglobulin G monoclonal antibodies isotype,
Descriptors:
- NZ1_9: Biotechnology
- NZ1_2: Biochemistry
- NZ6_1: Adaptive and innate immunity
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution :
Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 9 - announced on 2015-03-16
Amount awarded: 149 320 PLN
Project start date (Y-m-d): 2016-02-01
Project end date (Y-m-d): 2019-01-31
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Zestaw do elektroforezy DNA i białek z zasilaczem (10 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- CH2 Domain of Mouse IgG3 Governs Antibody Oligomerization, Increases Functional Affinity to Multivalent Antigens and Enhances Hemagglutination.Authors:Tomasz Klaus, Joanna BeretaAcademic press:Frontiers in Immunology (rok: 2018, tom: 9, strony: 1096), Wydawca: Holtzbrinck Publishing GroupStatus:PublishedDOI:10.3389/fimmu.2018.01096 - link to the publication
- Mouse IgG3 binding to macrophage-like cells is prevented by deglycosylation of the antibody or by Accutase treatment of the cellsAuthors:Alicja Karabasz, Monika Bzowska, Joanna Bereta, Maria Czarnek, Maja Sochalska, Tomasz KlausAcademic press:Scientific Reports (rok: 2020, tom: nd, strony: nd), Wydawca: Springer NatureStatus:SubmittedDOI: