Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Hyaluronic acid receptor stabilin-2: determination of the crystal structure and biochemical characterization of its binding to hyaluronic acid.

2015/17/N/NZ1/00025

Keywords:

stabilin-2 hyaluronic acid X-ray crystallography NMR

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Aleksandra Twarda-Cłapa 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 50 000 PLN

Project start date (Y-m-d): 2016-02-18

Project end date (Y-m-d): 2017-02-17

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer - laptop (4 669 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. 1,4,5-Trisubstituted Imidazole-Based p53-Mdm2/MdmX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.
    Authors:
    Twarda-Clapa, A., Krzanik, S., Kubica, K., Guzik, K., Labuzek, B., Neochoritis, C. G, Khoury, K., Kowalska, K., Czub, M., Dubin, G., Dömling, A., Skalniak, L., Holak, T. A.
    Academic press:
    Journal of Medicinal Chemistry (rok: 2017, tom: 60, strony: 4234-4244), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.7b00104 - link to the publication
  2. Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2.
    Authors:
    Twarda-Clapa, A., Labuzek, B., Krzemien, D., Musielak, B., Grudnik, P., Dubin, G., Holak, T. A.
    Academic press:
    Acta Crystallographica Section D - Structural Biology (rok: 2018, tom: 74, strony: 695-701), Wydawca: International Union of Crystallography
    Status:
    Published
    DOI:
    10.1107/S2059798318007271 - link to the publication
  1. Hyaluronic acid binding to Link domain of stabilin-2 receptor
    Authors:
    A. Twarda-Clapa, G. Dubin, T. A. Holak
    Conference:
    EMBO Workshop Cell Death, Inflammation and Cancer" (rok: 2017, ), Wydawca: EMBO
    Data:
    konferencja 10-14.01.2017
    Status:
    Published

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