Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Characterization of anticancer activity of new synthetic alpha-methylene-delta lactones in cancer cell lines.

2015/17/D/NZ3/02226

Keywords:

α-methylene-δ-laktones apoptosis proliferation oxidative stress anticancer agents NF-kB activity combination chemotherapy

Descriptors:

  • NZ3_3: Apoptosis
  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Gach-Janczak 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 440 580 PLN

Project start date (Y-m-d): 2016-02-22

Project end date (Y-m-d): 2021-02-21

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Szybkoobrotowa wirówka laboratoryjna z chłodzeniem i zestawem rotorów przystosowanych do wirowania probówek o pojemności od 0,2/1,5/2,2 do 100 ml (typu PCR, Eppendorf, Falcon) (54 000 PLN)
  2. Zestaw 4 nastawnych, autoklawowalnych pipet (0.5–10 μL, 10–100 μL, 100–1,000 μL, 500–5000 μL) (4 500 PLN)
  3. Wytrząsarka typu vortex (1 500 PLN)
  4. Laptop (3 900 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. A new hybrid δ-lactone induces apoptosis and potentiates anticancer activity of taxol in HL-60 human leukemia cells.
    Authors:
    Katarzyna Gach-Janczak, Joanna Drogosz-Stachowicz, Angelika Długosz-Pokorska, Rafał Jakubowski, Tomasz Janecki, Jacek Szymański, Anna Janecka
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 1479), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25071479 - link to the publication
  2. Evaluation of anticancer properties of a new α-methylene-δ-lactone DL-249 on two cancer cell lines
    Authors:
    Dorota K. Pomorska, Katarzyna Gach-Janczak, Rafał Jakubowski, Tomasz Janecki, Jacek Szymański, Anna Janecka
    Academic press:
    Open Life Sciences (dawniej Central European Journal of Biology) (rok: 2017, tom: 12, strony: 178-189), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Anticancer activity of a new α-methylene-δ-lactone DL-247 in selected cancer cell lines
    Authors:
    Katarzyna Gach-Janczak, Angelika Długosz-Pokorska, Joanna. Drogosz, Rafał Jakubowski, Jacek Szymański, Tomasz Janecki, Anna Janecka
    Conference:
    11th Joint Meeting on Medicinal Chemistry 2019 (rok: 2019, ), Wydawca: European Federation for Medicinal Chemistry
    Data:
    konferencja 27-06-30.07
    Status:
    Published

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