Projects funded by the NCN

Information on the principal investigator and host institution

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Keywords

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An effect of lipid metabolism changes on the function of skeletal and heart muscles and neurodegeneration process in mouse model of Huntington's disease

2015/17/N/NZ4/02841

Keywords:

Huntington's disease lipids metabolism myophaties cardiomiophaty neurodegeneration

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ4_11: Metabolism
  • NZ4_9: Systems neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Marta Tomczyk 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 145 200 PLN

Project start date (Y-m-d): 2016-03-24

Project end date (Y-m-d): 2020-03-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Sprzęt komputerowy Dell Latitude.
  2. Aparatura do pomiaru siły mięśniowej (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Huntingtin protein maintains balanced energetics in mouse cardiomyocytes
    Authors:
    Marta Tomczyk , Talita Glaser , Henning Ulrich , Ewa M. Slominska, Ryszard T. Smolenski
    Academic press:
    Nucleosides Nucleotides Nucleic Acids (rok: 2020, tom: 16, strony: 45299), Wydawca: Taylor and Francis Online
    Status:
    Published
    DOI:
    10.1080/15257770.2020.1815769. - link to the publication
  2. Changes in cardiac nucleotide metabolism in Huntington's disease.
    Authors:
    Toczek M, Kutryb-Zajac B, Zukowska P, Slominska EM, Isalan M, Mielcarek M, Smolenski RT.
    Academic press:
    Nucleosides Nucleotides Nucleic Acids (rok: 2016, tom: vol. 35 , 10/12, strony: 707-712), Wydawca: Taylor and Francis Online
    Status:
    Published
    DOI:
    10.1080/15257770.2016.1154969 - link to the publication
  3. An impaired metabolism of nucleotides underpins a novel mechanism of cardiac remodeling leading to Huntington's disease related cardiomyopathy
    Authors:
    Toczek M, Zielonka D, Zukowska P, Marcinkowski JT, Slominska E, Isalan M, Smolenski RT, Mielcarek M.
    Academic press:
    Biochimica et Biophysica Acta (rok: 2016, tom: vol. 1862,11, strony: s. 21472157), Wydawca: Science Direct
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2016.08.019 - link to the publication

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