Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Phosphorylation dynamics of STAT1, STAT3 and STAT5 proteins in breast cancer cell lines - systematic experimental and theoretical analysis

2015/17/B/NZ2/03692

Keywords:

JAK-STAT signalling pathway signalling aberrations in cancer modelling of signalling pathways statistical inference model selection

Descriptors:

  • NZ2_9: Systems biology
  • NZ2_10: Biological systems analysis, modelling and simulation

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Podstawowych Problemów Techniki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Komorowski 

Number of co-investigators in the project: 5

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 066 352 PLN

Project start date (Y-m-d): 2016-03-15

Project end date (Y-m-d): 2020-03-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Obliczeniowa stacja robocza.
  2. Obliczeniowa stacja robocza (10 000 PLN)
  3. Robot pipetujacy z akcesoriami (90 000 PLN)
  4. Laminar (30 000 PLN)
  5. Laptop (2 szt.) (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Information-theoretic analysis of multivariate single-cell signaling responses
    Authors:
    Tomasz Jetka,Karol Nienałtowski,Tomasz Winarski,Sławomir Błoński,Michał Komorowski
    Academic press:
    PLOS Computational Biology (rok: 2019, tom: 1, strony: 45314), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1007132 - link to the publication
  2. The Limited Information Capacity of Cross-Reactive Sensors Drives the Evolutionary Expansion of Signaling
    Authors:
    Michał Komorowski, Dan S Tawfik
    Academic press:
    Cell systems (rok: 2019, tom: 8, strony: 76-85), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.cels.2018.12.006 - link to the publication
  3. An information-theoretic framework for deciphering pleiotropic and noisy biochemical signaling
    Authors:
    Tomasz Jetka, Karol Nienałtowski, Sarah Filippi, Michael PH Stumpf, Michał Komorowski
    Academic press:
    Nature communications (rok: 2018, tom: 9, strony: 4591), Wydawca: Nature Springer
    Status:
    Published
    DOI:
    10.1038/s41467-018-07085-1 - link to the publication
  4. Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling
    Authors:
    Ulrike Billing, Tomasz Jetka, Lukas Nortmann, Nicole Wundrack, Michal Komorowski, Steffen Waldherr, Fred Schaper, Anna Dittrich
    Academic press:
    Communications biology (rok: 2019, tom: 2, strony: 27), Wydawca: Nature Springer
    Status:
    Published
    DOI:
    10.1038/s42003-018-0259-4 - link to the publication

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