Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The effect of SNAIL on microRNA transcriptome: significance for metastasis of mesenchymal tumors

2015/17/D/NZ5/02202

Keywords:

microRNAs SNAIL rhabdomyosarcoma tumor metastasis

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Klaudia Skrzypek 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 893 600 PLN

Project start date (Y-m-d): 2016-03-17

Project end date (Y-m-d): 2020-03-16

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Kolorowa drukarka laserowa (2 000 PLN)
  2. Orpogramowanie EndNote do tworzenia bibliografii (2 szt.) (3 000 PLN)
  3. Czytnik płytek (absorbancja, fluorescencja, luminescencja) z komputerem z oprogramowaniem (120 000 PLN)
  4. Laptop z oprogramowaniem (5 000 PLN)
  5. Opragramowanie GraphPad Prism do przygotowywania wykresów naukowych i statystyki (2 szt.) (4 000 PLN)
  6. Zestaw pipet (6 000 PLN)
  7. Urządzenie wielofunkcyjne.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (11)
  1. Interplay among SNAIL Transcription Factor, MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Regulation of Tumor Growth and Metastasis
    Authors:
    Klaudia Skrzypek, Marcin Majka
    Academic press:
    Cancers (rok: 2020, tom: 12(1), strony: E209), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12010209 - link to the publication
  2. Molecular mechanisms of epithelial to mesenchymal transition in tumor metastasis
    Authors:
    Artur Nieszporek, Klaudia Skrzypek, Grażyna Adamek, Marcin Majka
    Academic press:
    Acta Biochimica Polonica (rok: 2019, tom: 66(4), strony: 509-520), Wydawca: Acta Biochimica Polonica
    Status:
    Published
    DOI:
    10.18388/abp.2019_2899 - link to the publication
  3. SNAIL Promotes Metastatic Behavior of Rhabdomyosarcoma by Increasing EZRIN and AKT Expression and Regulating MicroRNA Networks
    Authors:
    Klaudia Skrzypek, Marta Kot, Paweł Konieczny, Artur Nieszporek, Anna Kusienicka, Małgorzata Lasota, Wojciech Bobela, Urszula Jankowska, Sylwia Kędracka-Krok, Marcin Majka
    Academic press:
    Cancers (rok: 2020, tom: 12(7), strony: 1870), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12071870 - link to the publication
  4. Enhancement of myogenic differentiation and inhibition of rhabdomyosarcoma progression by miR-28-3p and miR-193a-5p regulated by SNAIL
    Authors:
    Klaudia Skrzypek, Artur Nieszporek, Bogna Badyra, Małgorzata Lasota, Marcin Majka
    Academic press:
    Molecular Therapy - Nucleic Acids (rok: 2021, tom: 24, strony: 888-904), Wydawca: ScienceDirect, Elsevier
    Status:
    Published
    DOI:
    10.1016/j.omtn.2021.04.013 - link to the publication
  5. PAX7 transcription factor as an important regulator of alveolar rhabdomyosarcoma differentiation and progression
    Authors:
    Klaudia Skrzypek, Grażyna Adamek, Marta Kot, Bogna Badyra, Marcin Majka
    Academic press:
    International Journal of Molecular Sciences , Wydawca: MDPI
    Status:
    Submitted
    DOI:
    brak - link to the publication
  6. SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function
    Authors:
    Klaudia Skrzypek, Anna Kusienicka, Elzbieta Trzyna, Barbara Szewczyk, Aleksandra Ulman, Pawel Konieczny, Tomasz Adamus, Bogna Badyra, Marcin Kortylewski, Marcin Majka
    Academic press:
    Cell Death & Disease (rok: 2018, tom: 0,375, strony: 643), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41419-018-0693-8 - link to the publication
  1. Generation of TALEN and CRISPR/Cas9 nucleases targeting SNAI1 gene and microRNA
    Authors:
    Klaudia Skrzypek, Aleksandra Ulman, Barbara Szewczyk, Claudio Mussolino, Toni Cathomen, Marcin Majka
    Conference:
    Genome Editing for Gene and Cell Therapy (rok: 2016, ), Wydawca: Nature Medicine and VolkswagenStiftung
    Data:
    konferencja 03-04.11.2016
    Status:
    Published
  2. Novel mechanism of SNAIL transcription factor action in tumor metastasis
    Authors:
    Klaudia Skrzypek, Artur Nieszporek, Małgorzata Lasota, Paweł Konieczny, Marcin Majka
    Conference:
    TEMTIA-IX (The 9th EMT International Association Meeting) (rok: 2019, ), Wydawca: TEMTIA
    Data:
    konferencja 43780
    Status:
    Published
  3. SNAIL-dependent microRNAs are key regulators of rhabdomyosarcoma development and progression
    Authors:
    Klaudia Skrzypek, Artur Nieszporek, Grażyna Adamek, Bogna Badyra, Marcin Majka
    Conference:
    44th FEBS Congress, From Molecules to Living Systems (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 43652
    Status:
    Published
  4. SNAIL-microRNA axis is a key regulator of alveolar rhabdomyosarcoma progression
    Authors:
    Klaudia Skrzypek, Marcin Majka
    Conference:
    10th Anniversary International Conference of Contemporary Oncology (rok: 2018, ), Wydawca: Contemporary Oncology, TERMEDIA Publishing House
    Data:
    konferencja 21-23.03.2018
    Status:
    Published
  5. SNAIL1 as a key player in a biology of rhabdomyosarcoma
    Authors:
    Marcin Majka
    Conference:
    44th FEBS Congress, From Molecules to Living Systems (rok: 2019, ), Wydawca: FEBS Open Bio
    Data:
    konferencja 43652
    Status:
    Published
  6. The role of SNAIL-dependent microRNAs in alveolar rhabdomyosarcoma
    Authors:
    Artur Nieszporek, Klaudia Skrzypek, Marcin Majka
    Conference:
    4th International Conference of Cell Biology (rok: 2018, ), Wydawca: The Student Association of Cell Biology of the Jagiellonian University
    Data:
    konferencja 11-12.05.2018
    Status:
    Published
  7. Interplay between SNAIL transcription factor, microRNA and small nucleolar RNA in regulation of tumor progression
    Authors:
    Klaudia Skrzypek, Marcin Majka
    Conference:
    Noncoding RNAs: Form, Function, Physiology (rok: 2018, ), Wydawca: Keystone Symposia on Molecular and Cellular Biology
    Data:
    konferencja 25.02-01.03.2018
    Status:
    Published
  8. Novel mechanism of metastasis regulated by SNAIL transcription factor in mesenchymal tumors
    Authors:
    Klaudia Skrzypek, Artur Nieszporek, Anna Kusienicka, Małgorzata Lasota, Paweł Konieczny, Marcin Majka
    Conference:
    11th International Conference of Contemporary Oncology (rok: 2019, ), Wydawca: Contemporary Oncology, TERMEDIA Publishing House
    Data:
    konferencja 43537
    Status:
    Published
  9. Genome editing in tumor and iPS cells for the study of SNAI1 role in human diseases
    Authors:
    Klaudia Skrzypek, Aleksandra Ulman, Bogna Badyra, Maciej Sułkowski, Marcin Majka
    Conference:
    6th Central European Congress of Life Sciences Eurobiotech (rok: 2017, ), Wydawca: Targi w Krakowie
    Data:
    konferencja 11-14.09.2017
    Status:
    Published
  10. SNAIL-microRNA axis regulates rhabdomyosarcoma development
    Authors:
    Klaudia Skrzypek, Anna Kusienicka, Elżbieta Trzyna, Marcin Majka
    Conference:
    Progress in Developmental Biology (rok: 2017, ), Wydawca: The Committee of Developmental Biology of the Polish Academy of Arts and Sciences
    Data:
    konferencja 26.05.2017
    Status:
    Published
  11. The effect of SNAIL transcription factor on microRNA and small RNA expression profile in rhabdomyosarcoma
    Authors:
    Klaudia Skrzypek, Marcin Majka
    Conference:
    Eukaryotic RNA turnover (rok: 2017, ), Wydawca: EMBO reports, EMBOpress and University of Oxford
    Data:
    konferencja 10-13.07.2017
    Status:
    Published

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