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The effect of SNAIL on microRNA transcriptome: significance for metastasis of mesenchymal tumors

2015/17/D/NZ5/02202

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Klaudia Skrzypek

Number of co-investigators in the project: 3

Call

SONATA 9 – announced on 2015-03-16

Amount awarded
893 600 PLN
Project start date
2016-03-17
Project end date
2020-03-16
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Czytnik płytek (absorbancja, fluorescencja, luminescencja) z komputerem z oprogramowaniem. Cost: 120 000 PLN
  2. Kolorowa drukarka laserowa. Cost: 2 000 PLN
  3. Laptop z oprogramowaniem. Cost: 5 000 PLN
  4. Opragramowanie GraphPad Prism do przygotowywania wykresów naukowych i statystyki (2 pcs). Cost: 4 000 PLN
  5. Orpogramowanie EndNote do tworzenia bibliografii (2 pcs). Cost: 3 000 PLN
  6. Urządzenie wielofunkcyjne.
  7. Zestaw pipet. Cost: 6 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. SNAIL is a key regulator of alveolar rhabdomyosarcoma tumor growth and differentiation through repression of MYF5 and MYOD function

    Authors:
    Klaudia Skrzypek, Anna Kusienicka, Elzbieta Trzyna, Barbara Szewczyk, Aleksandra Ulman, Pawel Konieczny, Tomasz Adamus, Bogna Badyra, Marcin Kortylewski, Marcin Majka
    Academic press:
    Cell Death & Disease (year: 2018, volume: 0,375, pages: 643), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41419-018-0693-8 – link to the publication

  2. Molecular mechanisms of epithelial to mesenchymal transition in tumor metastasis

    Authors:
    Artur Nieszporek, Klaudia Skrzypek, Grażyna Adamek, Marcin Majka
    Academic press:
    Acta Biochimica Polonica (year: 2019, volume: 66(4), pages: 509-520), Publisher: Acta Biochimica Polonica
    Status:
    Published
    DOI:
    10.18388/abp.2019_2899 – link to the publication

  3. Enhancement of myogenic differentiation and inhibition of rhabdomyosarcoma progression by miR-28-3p and miR-193a-5p regulated by SNAIL

    Authors:
    Klaudia Skrzypek, Artur Nieszporek, Bogna Badyra, Małgorzata Lasota, Marcin Majka
    Academic press:
    Molecular Therapy - Nucleic Acids (year: 2021, volume: 24, pages: 888-904), Publisher: ScienceDirect, Elsevier
    Status:
    Published
    DOI:
    10.1016/j.omtn.2021.04.013 – link to the publication

  4. SNAIL Promotes Metastatic Behavior of Rhabdomyosarcoma by Increasing EZRIN and AKT Expression and Regulating MicroRNA Networks

    Authors:
    Klaudia Skrzypek, Marta Kot, Paweł Konieczny, Artur Nieszporek, Anna Kusienicka, Małgorzata Lasota, Wojciech Bobela, Urszula Jankowska, Sylwia Kędracka-Krok, Marcin Majka
    Academic press:
    Cancers (year: 2020, volume: 12(7), pages: 1870), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12071870 – link to the publication

  5. Interplay among SNAIL Transcription Factor, MicroRNAs, Long Non-Coding RNAs, and Circular RNAs in the Regulation of Tumor Growth and Metastasis

    Authors:
    Klaudia Skrzypek, Marcin Majka
    Academic press:
    Cancers (year: 2020, volume: 12(1), pages: E209), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12010209 – link to the publication

Articles in post-conference publications (11)

  1. The effect of SNAIL transcription factor on microRNA and small RNA expression profile in rhabdomyosarcoma

    Authors:
    Klaudia Skrzypek, Marcin Majka
    Conference:
    Eukaryotic RNA turnover (year: 2017, pages: 100), Publisher: EMBO reports, EMBOpress and University of Oxford
    Date:
    conference 10-13.07.2017
    Status:
    Published

  2. Novel mechanism of metastasis regulated by SNAIL transcription factor in mesenchymal tumors

    Authors:
    Klaudia Skrzypek, Artur Nieszporek, Anna Kusienicka, Małgorzata Lasota, Paweł Konieczny, Marcin Majka
    Conference:
    11th International Conference of Contemporary Oncology (year: 2019, pages: 8), Publisher: Contemporary Oncology, TERMEDIA Publishing House
    Date:
    conference 43537
    Status:
    Published

  3. The role of SNAIL-dependent microRNAs in alveolar rhabdomyosarcoma

    Authors:
    Artur Nieszporek, Klaudia Skrzypek, Marcin Majka
    Conference:
    4th International Conference of Cell Biology (year: 2018, pages: 108), Publisher: The Student Association of Cell Biology of the Jagiellonian University
    Date:
    conference 11-12.05.2018
    Status:
    Published

  4. SNAIL-microRNA axis is a key regulator of alveolar rhabdomyosarcoma progression

    Authors:
    Klaudia Skrzypek, Marcin Majka
    Conference:
    10th Anniversary International Conference of Contemporary Oncology (year: 2018, pages: 14), Publisher: Contemporary Oncology, TERMEDIA Publishing House
    Date:
    conference 21-23.03.2018
    Status:
    Published

  5. SNAIL1 as a key player in a biology of rhabdomyosarcoma

    Authors:
    Marcin Majka
    Conference:
    44th FEBS Congress, From Molecules to Living Systems (year: 2019, pages: 57-58), Publisher: FEBS Open Bio
    Date:
    conference 43652
    Status:
    Published

  6. Novel mechanism of SNAIL transcription factor action in tumor metastasis

    Authors:
    Klaudia Skrzypek, Artur Nieszporek, Małgorzata Lasota, Paweł Konieczny, Marcin Majka
    Conference:
    TEMTIA-IX (The 9th EMT International Association Meeting) (year: 2019, pages: 35), Publisher: TEMTIA
    Date:
    conference 43780
    Status:
    Published

  7. SNAIL-dependent microRNAs are key regulators of rhabdomyosarcoma development and progression

    Authors:
    Klaudia Skrzypek, Artur Nieszporek, Grażyna Adamek, Bogna Badyra, Marcin Majka
    Conference:
    44th FEBS Congress, From Molecules to Living Systems (year: 2019, pages: 352), Publisher: FEBS Open Bio
    Date:
    conference 43652
    Status:
    Published

  8. Interplay between SNAIL transcription factor, microRNA and small nucleolar RNA in regulation of tumor progression

    Authors:
    Klaudia Skrzypek, Marcin Majka
    Conference:
    Noncoding RNAs: Form, Function, Physiology (year: 2018, pages: 131), Publisher: Keystone Symposia on Molecular and Cellular Biology
    Date:
    conference 25.02-01.03.2018
    Status:
    Published

  9. Genome editing in tumor and iPS cells for the study of SNAI1 role in human diseases

    Authors:
    Klaudia Skrzypek, Aleksandra Ulman, Bogna Badyra, Maciej Sułkowski, Marcin Majka
    Conference:
    6th Central European Congress of Life Sciences Eurobiotech (year: 2017, pages: 63), Publisher: Targi w Krakowie
    Date:
    conference 11-14.09.2017
    Status:
    Published

  10. SNAIL-microRNA axis regulates rhabdomyosarcoma development

    Authors:
    Klaudia Skrzypek, Anna Kusienicka, Elżbieta Trzyna, Marcin Majka
    Conference:
    Progress in Developmental Biology (year: 2017, pages: 52), Publisher: The Committee of Developmental Biology of the Polish Academy of Arts and Sciences
    Date:
    conference 26.05.2017
    Status:
    Published

  11. Generation of TALEN and CRISPR/Cas9 nucleases targeting SNAI1 gene and microRNA

    Authors:
    Klaudia Skrzypek, Aleksandra Ulman, Barbara Szewczyk, Claudio Mussolino, Toni Cathomen, Marcin Majka
    Conference:
    Genome Editing for Gene and Cell Therapy (year: 2016, pages: P19), Publisher: Nature Medicine and VolkswagenStiftung
    Date:
    conference 03-04.11.2016
    Status:
    Published

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